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Accepted manuscript

Causal Association of Folic Acid Supplementary Therapy and Gastric Ulcer: A Mendelian Randomization Study

Published online by Cambridge University Press:  24 October 2024

Fuhao Li Open the ORCID record for Fuhao Li [Opens in a new window] ,
Fengming Huang ,
Yulong Tang ,
Fan Zhang ,
Hao Jiang ,
Jun Chen  and
Bin Lv
Fuhao Li*
Affiliation:
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310003, Zhejiang, China Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
Fengming Huang*
Affiliation:
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310003, Zhejiang, China Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
Yulong Tang*
Affiliation:
The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
Fan Zhang
Affiliation:
Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
Hao Jiang
Affiliation:
Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
Jun Chen*
Affiliation:
Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
Bin Lv*
Affiliation:
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310003, Zhejiang, China Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou 310006, China
*
#co-author: Fuhao Li, Email address: [email protected]; Fengming Huang, Email address: [email protected]; Yulong Tang, Email address: [email protected]
#co-author: Fuhao Li, Email address: [email protected]; Fengming Huang, Email address: [email protected]; Yulong Tang, Email address: [email protected]
#co-author: Fuhao Li, Email address: [email protected]; Fengming Huang, Email address: [email protected]; Yulong Tang, Email address: [email protected]
*Corresponding Author: Jun chen, Email address: [email protected]; 548 Binwen Road, Binwen District, Hangzhou City, Zhejiang Province, China; Bin Lv, 54 Post and Telecommunication Road in Shangcheng District, Hangzhou, Zhejiang, 310006, China Email address: [email protected]
*Corresponding Author: Jun chen, Email address: [email protected]; 548 Binwen Road, Binwen District, Hangzhou City, Zhejiang Province, China; Bin Lv, 54 Post and Telecommunication Road in Shangcheng District, Hangzhou, Zhejiang, 310006, China Email address: [email protected]
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Abstract

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Previous research has suggested a potential link between folic acid supplementary therapy and gastric ulcers. To investigate this relationship further, we conducted a Mendelian randomization (MR) analysis using data from the UK Biobank. Our analysis primarily employed inverse variance-weighted (IVW) methods, including both fixed-effect and random-effect models. To ensure the robustness of our findings, additional methods such as the simple median, the weighted median, and the penalized weighted median were also applied. The MR analysis aimed to explore the causal effect of FA supplementary therapy on gastric ulcers. Seven single nucleotide polymorphisms (SNPs) at genetic loci associated with FA supplementary therapy were identified. Both the random-effect and fixed-effect IVW models indicated that genetically predicted FA supplementary therapy significantly reduced the risk of gastric ulcers (OR, 0.870; 95% CI, 0.826-0.917, p<0.001). This result was consistent across other methods, with similar outcomes observed using the simple median (OR, 0.835; 95% CI, 0.773-0.901, p<0.001), the weighted median (OR, 0.854; 95% CI, 0.794-0.919, p<0.001), and the penalized weighted median (OR, 0.849; 95% CI, 0.789-0.914, p<0.001). Leave-one-out sensitivity analysis confirmed that no individual SNP significantly drove the association between FA supplementary therapy and gastric ulcers. This MR study provides genetic evidence that FA supplementary therapy may decrease the risk of gastric ulcers.

Keywords

mendelian randomizationfolic acidgastric ulcersgeneticsfolate
Type
Research Article
Information
British Journal of Nutrition , Accepted manuscript , pp. 1 - 19
Copyright
© The Authors 2024