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The B-vitamin group and the activity of hepatic microsomal mixed-function oxidases of the growing Wistar rat

Published online by Cambridge University Press:  24 July 2007

R. Miltenberger  and
U. Oltersdorf
R. Miltenberger
Affiliation:
Institut fuer Ernaehrungswissenschaft der Justus Liebig Universitaet, D-6300 Giessen, Federal Republic of Germany
U. Oltersdorf
Affiliation:
Institut fuer Ernaehrungswissenschaft der Justus Liebig Universitaet, D-6300 Giessen, Federal Republic of Germany
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Abstract

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1. Male Wistar rats were given isoenergetic, semi-synthetic diets deficient in thiamin, riboflavin, pyrid-oxine or all the B-vitamins.

2. In rats given these deficient diets the ‘sleeping time’ induced with pentobarbital (PB) and the ‘paralysis time’ with zoxazolamine (Zz) were prolonged.

3. The tolerance effect against both drugs was nearly independent of the levels of B-vitamins in the diets.

4. In preparations from vitamin-B deficient animals the activities of the following hepatic microsomal enzymes were reduced: the aliphatic hydroxylase of PB, the aromatic hydroxylases of aniline (EC 1.14.14.1) and of Zz, the N-demethylase of aminopyrine, the UDP glucuronyltransferase (EC 2.4.1.17) of p-nitrophenol. The reactions most influenced were those of ‘type-1’ substrates, particularly those involving the hydroxylases.

5. The effects observed were caused mainly by deficiency of riboflavin and to a lesser extent of thiamin or pyridoxine.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 39 , Issue 1 , January 1978 , pp. 127 - 137
Copyright
Copyright © The Nutrition Society 1978

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