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Blood indices of selenium and mercury, and their correlations with fish intake, in young people living in Britain

Published online by Cambridge University Press:  08 March 2007

C. J. Bates ,
A. Prentice ,
M. C. Birch ,
H. T. Delves  and
K. A. Sinclair
C. J. Bates*
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
A. Prentice
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
M. C. Birch
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
H. T. Delves
Affiliation:
SAS Trace Element Unit, Chemical Pathology, University of Southampton, Southampton General Hospital, Southampton, UK
K. A. Sinclair
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
*
*Corresponding author: Dr C.J. Bates, fax +44 (0) 1223 437515, email [email protected]
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Abstract

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Relationships between Se and Hg in erythrocytes, and between these indices and intakes of fish and other foods, were studied as an adjunct to the British National Diet and Nutrition Survey (NDNS) of young people aged 4–18 years. Hg was measured in 965 packed erythrocyte samples by inductively coupled plasma mass spectrometry. Fe measurements permitted the calculation of whole-blood Hg. Erythrocyte and plasma Se, and 7d weighed dietary intake estimates, were available. Erythrocyte Hg was positively skewed, normalised by log-transformation. It was 20% higher in girls than boys (3·17 v. 2·65nmo/, P=0·004), and increased with age in boys but not girls. It was directly and strongly correlated with erythrocyte or plasma Se. Hg and Se concentrations were directly correlated with fish intake. Certain other food groups were also directly correlated with Se and Hg concentrations, but less strongly than for fish. The strength and consistency of the relationship between erythrocyte Hg and Se suggests an important chemical link. Previous studies suggest that Se protects against the toxicity of Hg, and that fish is an important source of both. No toxic levels of Hg were found, which is reassuring because of the known health benefits of fish consumption, especially oily fish. Hg intakes need to be monitored, especially in women of child-bearing age, to ensure that Food Standards Agency guidelines are met.

Keywords

MercurySeleniumBiochemical indicesFood intakesFishChildrenBritish National Diet and Nutrition survey
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 523 - 531
Copyright
Copyright © The Nutrition Society 2006

References

Bates, CJ, Thane, CW, Prentice, A, Delves, HT & Gregory, J (2002) Selenium status and associated factors in a British National Diet and Nutrition Survey: young people aged 4–18 y. Eur J Clin Nutr 56, 873–881.Google Scholar
Berglund, M, Lind, B, Bjornberg, KA, Palm, B, Einarsson, O & Vahter, M (2005) Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment. Environ Health 4, 20.Google Scholar
Bouzan, C, Cohen, JT, Connor, WE, Kris-Etherton, PM, Gray, GM, Konig, A, Lawrence, RS, Savitz, DA & Teutsch, SM (2005) A quantitative analysis of fish consumption and stroke risk. Am J Prev Med 29, 347–352.CrossRefGoogle ScholarPubMed
Brune, D, Nordberg, G, Vesterberg, O, Gerhardsson, I & Wester, P (1991) A review of normal concentrations of mercury in human blood. Sci Total Environ 100, 235–282.Google Scholar
Cabanero, AI, Carvalho, C, Madrid, Y, Batoreu, C & Camara, C (2005) Quantification and speciation of mercury and selenium in fish samples of high consumption in Spain and Portugal. Biol Trace Elem Res 103, 17–35.CrossRefGoogle ScholarPubMed
Clarkson, T (2002) The three modern faces of mercury. Environ Health Perspect 110, 11–23.Google Scholar
Clarkson, T, Hursh, J, Sager, P & Syversen, T (1988) Mercury. In Biological Monitoring of Toxic Metals, pp. 199–246 [Clarkson, T, Friber, L, Nordberg, G and Sager, PR, editors]. New York: Plenum Press.CrossRefGoogle Scholar
Clarkson, T, Magos, L & Myers, G (2003) The toxicology of mercury – current exposures and clinical manifestations. New Engl J Med 349, 1731–1737.Google Scholar
Combs, G (2001) Selenium in global food systems. Br J Nutr 85, 517–547.CrossRefGoogle ScholarPubMed
Cuvin-Aralar, M & Furness, R (1991) Mercury and selenium interaction: a review. Ecotoxicol Environ Safety 21, 348–364.CrossRefGoogle ScholarPubMed
Delves, HT & Sieniawska, CE (1997) Simple method for the accurate determination of selenium in serum by using inductively coupled plasma mass spectrometry. J Anal At Spectrom 12, 387–389.CrossRefGoogle Scholar
Drasch, G, Mailander, S, Schhlosser, C & Roider, G (2000) Content of non-mercury-associated selenium in human tissues. Biol Trace Elem Res 77, 219–230.CrossRefGoogle ScholarPubMed
Environmental Protection Agency (1997) Mercury Study Report to Congress, vol. IV, An Assessment of Exposure to Mercury in the United States. EPA-452/R-97-006. Cincinnati, USA: EPA Environmental Criteria and Assessment Office.Google Scholar
Food Standards Agency (2002) Mercury in imported fish and shellfish and UK farmed fish and their products. Food Surveillance Information Sheet 40/03. http//:www.food.gov.uk/scienc/urveillanc/sis-2003/fsis402003Google Scholar
Ganther, H (1978) Modification of methyl-mercury toxicity and metabolism by selenium and vitamin E. Environ Health Perspect 25, 71–76.Google Scholar
Grandjean, P, Nielsen, G, Jorgensen, P & Horder, M (1992) Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest 52, 321–337.Google Scholar
Grandjean, P, Weihe, P, White, R, Debes, F, Araki, S, Yokoyama, K, Murata, K, Sorensen, N, Dahl, R & Jorgensen, P (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19, 417–428.CrossRefGoogle ScholarPubMed
Gregory, J, Lowe, S, Bates, C, Prentice, A, Jackson, L, Smithers, G, Wenlock, R & Farron, M (2000) National Diet and Nutrition Survey: Young People Aged 4 to 18 Years, vol. 1, Report of the Diet and Nutrition Survey. London: The Stationery Office.Google Scholar
Harris, H, Pickering, I & George, G (2003) The chemical form of mercury in fish. Science 301, 1203.CrossRefGoogle ScholarPubMed
Hol, PJ, Vamnes, JS, Gjerdet, NR, Eide, R & Isrenn, R (2002) Dental amalgam affects urinary selenium excretion. Biol Trace Elem Res 85, 137–147.CrossRefGoogle ScholarPubMed
Hongo, T, Watanabe, C, Himeno, S & Suzuki, T (1985) Relationship between erythrocyte mercury and selenium in erythrocyte, plasma and urine. Nutr Res 5, 1285–1289.Google Scholar
International Programme for Chemical Safety (1991) Inorganic Mercury Environmental Health Criteria 118. Geneva: WHO.Google Scholar
Karita, K & Suzuki, T (2002) Fish eating and variations in selenium and mercury levels in plasma and erythrocytes in free-living healthy Japanese men. Biol Trace Elem Res 90, 71–81.CrossRefGoogle ScholarPubMed
Kershaw, TG, Clarkson, TW & Dhahir, PH (1980) The relationship between blood levels and dose of methylmercury in man. Arch Environ Health 35, 28–36.CrossRefGoogle ScholarPubMed
Koeman, J, van de Ven, W, de Goeij, J, Tjioe, P & van Haaften, J (1975) Mercury and selenium in marine mammals and birds. Sci Total Environ 3, 279–287.CrossRefGoogle ScholarPubMed
Kosta, L, Byrne, A & Zelenko, V (1975) Correlation between selenium and mercury in man following exposure to inorganic mercury. Nature 254, 238–239.CrossRefGoogle ScholarPubMed
Luoma, P, Nayha, S, Pyy, L, Korpela, H & Hassi, J (1992) Blood mercury and serum selenium concentrations in reindeer herders in the arctic area of northern Finland. Arch Toxicol Suppl 15, 172–175.CrossRefGoogle ScholarPubMed
Magos, L & Webb, M (1980) The interactions of selenium with mercury. In Critical Reviews in Toxicology, pp. 1–42 [Goldberg, L, editor]. Cleveland, OH: CRC Press.Google Scholar
Mahaffey, K & Mergler, D (1998) Blood levels of total and organic mercury in residents of the Upper St Lawrence River Basin, Quebec: association with age, gender, and fish consumption. Environ Res 77, 104–114.CrossRefGoogle Scholar
Ministry of Agriculture, Fisheries and Food, (1998) Survey of the concentrations of metals and other elements in marine fish and shellfish. Food Surveillance Information Sheet 151. http//archive.food.gov.uk/maff/archive/food/infsheet/1998/no151/151fish.htm.Google Scholar
Ministry of Agriculture, Fisheries and Food (1999) 1997 Total Diet Study: Aluminium, Arsenic, Cadmium, Chromium, Copper, Lead, Mercury, Nickel, Selenium, Tin, Zinc. Food Surveillance Information Sheet no. 191. http://archive.food.gov.uk/maff/archive/food/infsheet/1999/no191/191tds.htmGoogle Scholar
National Research Council (2000) Toxicological Effects of Methylmercury. Washington, DC: National Academy Press.Google Scholar
Nylander, M & Weiner, J (1991) Mercury and selenium concentrations and their interrelations in organs from dental staff and the general population. Br J Industr Med 48, 729–734.Google Scholar
Rayman, M (2000) The importance of selenium to human health. Lancet 356, 233–241.Google Scholar
Rayman, M (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64, 527–542.CrossRefGoogle ScholarPubMed
Ruston, D, Hoare, S, Henderson, L, Gregory, J, Bates, CJ, Prentice, A, Perks, J, Swan, G & Farron, M (2004) National Diet and Nutrition Survey: Adults Aged 19 to 64 Years, vol. 4, Nutritional Status (Anthropometry and blood Analytes), Blood Pressure and Physical Activity. London: The Stationery Office.Google Scholar
Sanzo, JM, Dorronsoro, M, Amiano, P, Amurrio, A, Aguinagalde, FX, Azpiri, MA and the EPIC Group of Spain (European Prospective Investigation into Cancer and Nutrition) (2001) Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain. Publ Hlth Nutr 4, 981–988.CrossRefGoogle Scholar
Scientific Advisory Committee on Nutrition/Committee on Toxicity (2004) Advice on fish consumption: benefits and risks. London: The Stationery Office.Google Scholar
Sherlock, J, Hislop, J, Newton, D, Topping, G & Whittle, K (1984) Elevation of mercury in human blood from controlled chronic ingestion of methylmercury in fish. Hum Toxicol 3, 117–131.CrossRefGoogle ScholarPubMed
Smith, KM & Sahyoun, NR (2005) Fish consumption: recommendations versus advisories, can they be reconciled? Nutr Rev 63, 39–46.CrossRefGoogle ScholarPubMed
Svensson, B-G, Schutz, A, Nilsson, A, Akesson, I, Akesson, B & Skerfving, S (1992) Fish as a source of exposure to mercury and selenium. Sci Total Environ 126, 61–74.CrossRefGoogle ScholarPubMed
Thomson, CD, Robinson, MF, Butler, JA & Whanger, PD (1993) Long-term supplementation with selenate and selenomethionine: selenium and glutathione peroxidase (EC 1.11. 1. 9) in blood components of New Zealand women. Br J Nutr 69, 577–588.CrossRefGoogle ScholarPubMed
Walker, A, Gregory, J, Bradnock, G, Nunn, J, White, D (2000) National Diet and Nutrition Survey: Young People aged 4–18 Years, vol. 2, Report of the Oral Health Survey. London: The Stationery Office.Google Scholar
Watanabe, C (2002) Modification of mercury toxicity by selenium: practical importance? Tohoku J Exp Med 196, 71–77.Google Scholar
Whanger, P (1992) Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. J Trace Elem Electr Health Dis 6, 209–221.Google Scholar
World Health Organization (1972) Evaluation of mercury, lead, cadmium, and the food additives amaranth, diethylpyrocarbonate and octyl gallate. WHO Food Additive Series no. 4. http://www.inchem.org/documents/jecfa/jecmono/v004je02.htmGoogle Scholar
World Health Organization (1976) Environmental Health Criteria 1. Mercury. Geneva: United Nations Environmental Programm/HO.Google Scholar
World Health Organization (2003) Safety evaluation of certain food additives and contaminants: methylmercury. Summary and conclusions of http://ftp.fao.org/es/esn/jecfa61sc.pdf (07/10/2003)Google Scholar
Yoneda, S & Suzuki, K (1997) Equimolar Hg-Se complex binds to selenoprotein P. Biochem Biophys Res Commun 231, 7–11.Google Scholar
Ysart, G, Miller, P, Croasdale, M, Crews, H, Robb, P, Baxter, M, de L'Argy, C & Harrison, N (2000) 1997 UK Total Diet Study – dietary exposures to aluminium, arsenic, cadmium, chromium, copper, lead mercury, nickel, selenium, tin and zinc. Food Additives Contam 17, 775–786.CrossRefGoogle ScholarPubMed