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Biotin supply by large bowel bacteria in minipigs: Evidence from intracaecal avidin

Published online by Cambridge University Press:  09 March 2007

Johanne Scholtissek ,
Christian A. Barth ,
Hans Hagemeister  and
Martin Frigg
Johanne Scholtissek
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Christian A. Barth
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Hans Hagemeister
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Martin Frigg
Affiliation:
Department of Animal Nutrition and Health, F. Hoffmann–La-Roche, CH 4002 Bade, Switzerland
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Abstract

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The influence of a change of colonic availability of biotin on biotin status was studied. This was done by inhibition of biotin absorption by intracaecal avidin infusion. Five adult minipigs with a permanent caecal ‘T’ cannula were fed on a semi-synthetic, biotin-deficient diet for 4 months. Following an 8-week adaptation period there were nine sequential 1-week infusion periods with or without oral lactulose or antibiotics. Avidin infusion during weeks 2, 5 and 8 amounted to 18 mg/d (13 U/mg). Plasma biotin concentrations were not changed by avidin infusions. There was a significant average 84% rise in faecal biotin excretion during the avidin periods. Urinary biotin output following avidin decreased by 21 %. This is taken as evidence that biotin synthesized by colonic bacteria is available for host metabolism. A rough estimate shows that under basal conditions 1.7–17% of the metabolic allowance may be covered by this metabolic route.

Keywords

Biotin synthesisBiotin absorptionColonic microfloraMinipig
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 64 , Issue 3 , November 1990 , pp. 715 - 720
Copyright
Copyright © The Nutrition Society 1990

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