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Biomarkers and functional foods for obesity and diabetes

Published online by Cambridge University Press:  09 March 2007

James O. Hill  and
John C. Peters
James O. Hill*
Affiliation:
Center for Human Nutrition, University of Colorado, Health Sciences Center, Box C225, 4200 East Ninth Avenue, Denver, CO 80262, USA
John C. Peters
Affiliation:
Procter & Gamble Company, 6071 Center Hill Road, Cincinnati, OH 45224, USA
*
*Corresponding author: Dr. J. O. Hill, fax +1 303 315 3273, email [email protected]
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Abstract

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Obesity has reached epidemic proportions in many countries around the world. Because of the close relationship between obesity and type 2 diabetes, an epidemic of diabetes is close behind the obesity epidemic. Preventing and treating obesity is becoming an increasing priority. In the United States, over 60% of the adult population is overweight or obese and thus at increased risk of developing diabetes and cardiovascular disease. While the aetiology of obesity and diabetes is complex, diet clearly plays an important role both in the development and management of these diseases. There is interest in functional foods that could help in prevention and/or management of obesity and type 2 diabetes. This could involve food products that help management of ‘hunger’ or that increase ‘satiety’. It could also involve foods that contribute to more inefficient use of ingested energy (i.e. foods that stimulate energy expenditure more than would be expected from their energy content). As the concept of insulin sensitivity becomes generally more accepted by health care professionals and the public, foods may be targeted towards maximizing insulin sensitivity and towards ‘prevention’ of diabetes. In addition to foods that impact upon body weight, these may include foods that affect the glucose and/or insulin levels that are seen either following the ingestion of food or later in the day. The present paper reviews the complex aetiology of obesity and diabetes and considers a potential role for functional foods in prevention and treatment of obesity and diabetes.

Keywords

ObesityType 2 diabetesBiomarkersFunctional foods
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S2 , November 2002 , pp. S213 - S218
Copyright
Copyright © The Nutrition Society 2002

References

Astrup, A, Buemann, B, Christensen, NJ, Toubro, S, Thorbek, G, Victor, OJ & Quaade, F (1992) The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women. Metabolism 41, 686–688.CrossRefGoogle ScholarPubMed
Atkins, RC (1992) Dr. Atkins' New Diet Revolution. New York: Avon Books.Google Scholar
Brand-Miller, J, Wolever, TMS, Colagiuri, S & Foster-Powell, K (1999) The Glucose Revolution. New York: Marlowe & Company.Google Scholar
Bray, GA, Lovejoy, JC, Most-Windhauser, M, Smith, SR, Volaufova, J, Denkins, Y, DeJonge, L, Rood, J, Lefevre, M, Eldridge, AL & Peters, JC (2002) A nine-month randomized clinical trial comparing a fat-substituted and fat-reduced diet in healthy obese men: The Ole Study. American Journal of Clinical Nutrition in press.CrossRefGoogle Scholar
Cefalu, WT, Bell-Farrow, AD, Stegner, J, Shong, QW, King, T, Morgan, T & Terry, JG (1999) Effect of chromium picolinate on insulin sensitivity in vivo. Journal of Trace Elements in Experimental Medicine 12, 71–83.3.0.CO;2-8>CrossRefGoogle Scholar
Davies, KM, Heaney, RP, Recker, RR, Lappe, JM, Barger-Lux, J, Rafferty, K & Hinders, S (2000) Calcium intake and body weight. Journal of Clinical Endocrinology and Metabolism 85, 4635–4638.Google ScholarPubMed
Eades, MR & Eades, MD (1996) Protein Power. New York: Bantam Books.Google Scholar
Fagot-Campagna, A, Pettitt, DJ, Englegau, MM, Burrows, NR, Geiss, LS, Valdez, R, Beckles, GL, Saadine, J, Gregg, EW, Williamson, DF & Jarayan, KMV (2000) Type 2 diabetes among North American children and adolescents: an epidemio logic review and a public health perspective. Journal of Pediatrics 136, 664–672.CrossRefGoogle Scholar
Grunwald, GK, Seagle, HM, Peters, JC & Hill, JO (2001) Quantifying and separating the effects of macronutrient composition and non-energetic food components on energy density. British Journal of Nutrition 86, 265–276.CrossRefGoogle Scholar
Heitman, BL & Lissner, L (1995) Dietary underreporting by obese individuals — is it specific or non-specific? British Medical Journal 311, 986–989.CrossRefGoogle Scholar
Hill, JO & Prentice, AM (1995) Sugar and body weight regulation. American Journal of Clinical Nutrition 62, 264S–274S.CrossRefGoogle ScholarPubMed
Hill, JO, Seagle, HM, Johnson, SL, Smith, S, Reed, GW, Tran, ZV, Cooper, D, Stone, M & Peters, JC (1998) Effects of 14 days of covert substitution of Olestra on spontaneous food intake. American Journal of Clinical Nutrition 67, 1178–1185.CrossRefGoogle Scholar
Jones, PJH & Schoeller, DA (1988) Polyunsaturated:saturated ratio of diet fat influences energy substrate utilization in the human. Metabolism 37, 145–151.CrossRefGoogle ScholarPubMed
Kristal, AR, Beresford, SA & Lazovich, D (1994) Assessing change in diet-intervention research. American Journal of Clinical Nutrition 59, 185S–189S.CrossRefGoogle ScholarPubMed
Lebovitz, HE (1994) Stepwise and combination drug therapy for the treatment of NIDDM. Diabetes Care 17, 1542–1544.CrossRefGoogle ScholarPubMed
Lewis, CJ, Park, YK, Dexter, PB & Yetley, EA (1992) Nutrient intakes and body weight of persons consuming high and moderate levels of sugars. Journal of the American Dietetic Association 92, 703–713.CrossRefGoogle ScholarPubMed
Lohman, TG (2001) Body composition. In Eating Disorders and Obesity: A Comprehensive Handbook, 2nd ed., pp. 62–66 [Fairburn, C and Brownell, K editors]. New York: Guilford.Google Scholar
Ludwig, DS (2000) Dietary glycemic index and body weight regulation. Nutrition Society of Australia 24, 286–293.Google Scholar
Ludwig, DS, Pereira, MA, Kroenke, CH, Hilner, JE, Van Horn L, , Slattery, ML & Jacobs, DR Jr (1999) Dietary fiber, weight gain and cardiovascular disease risk factors in young adults: the CARDIA study. Journal of the American Medical Association 282, 1539–1546.CrossRefGoogle Scholar
Ludwig, DS, Peterson, KE & Gortmaker, SL (2001)Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 357, 505–508.CrossRefGoogle ScholarPubMed
Maggio, CA & Pi-Sunyer, FX (1997) The prevention and treatment of obesity. Application to type 2 diabetes. Diabetes Care 20, 1744–1766.CrossRefGoogle ScholarPubMed
Mattes, RD (1996) Dietary compensation by humans for supplemental energy provided as ethanol or carbohydrate in fluids. Physiology and Behavior 59, 179–187.CrossRefGoogle ScholarPubMed
Melby, CR, Ho, R & Hill, JO (1998) Assessment of energy expenditure. In Physical Activity and Obesity, pp. 204–233 [Bouchard, C, editor]. Champaign, IL: Human Kinetics.Google Scholar
Mokdad, H, Bowman, BA, Ford, ES, Vinicor, F, Marks, JS & Koplan, JP (2001) The continuing epidemics of obesity and diabetes in the United States. Journal of the American Medical Association 286, 1195–1200.CrossRefGoogle ScholarPubMed
National Center for Health Statistics(1999) Prevalence of overweight and obesity among adults: United States(electronic citation). http://www.cdc.gov//nchs/products/pubs/pubd/hestats/obese/obsc99.htm.Google Scholar
National Institutes of Health (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults — the Evidence Report. Obesity Research 6, Suppl. 2, 51S–210S.Google Scholar
Nieman, DC, Trone, G & Austin, M (2001) Validation of a new handheld device for measuring resting metabolic rate. Obesity Research 9, Suppl. 3, 202S.Google Scholar
Pereira, MA & Ludwig, DS (2001) Dietary fiber and body weight regulation: observations and mechanisms. Pediatrics Clinics of North America 48, 969–980.CrossRefGoogle ScholarPubMed
Pi-Sunyer, FX (1993) Medical hazards of obesity. Annals of Internal Medicine 119, 655–660.CrossRefGoogle ScholarPubMed
Reaven, GM (1998) Role of insulin resistance in human disease. Diabetes 37, 1595–1607.CrossRefGoogle Scholar
Rolls, B & Barnett, RA (2000) Volumetrics. New York: Harper-Collins.Google Scholar
Rolls, BJ & Bell, EA (1999) Intake of fat and carbohydrate: role of energy density. European Journal of Clinical Nutrition 52, 1–8.Google Scholar
Rolls, BJ & Bell, EA (2000) Dietary approaches to the treatment of obesity. Medical Clinicians of North America 84, 401–418.CrossRefGoogle Scholar
Rolls, BJ, Hetherington, M & Burley, VJ (1988) The specificity of satiety: the influence of foods of different macronutrient content on the development of satiety. Physiology and Behavior 43, 145–153.CrossRefGoogle ScholarPubMed
Rumpler, W, Seale, J, Clevidence, B, Judd, J, Wiley, E, Yamamoto, S, Komatsu, T, Sawaki, T, Ishikura, Y & Hosoda, K (2001) Oolong tea increases metabolic rate and fat oxidation in men. Journal of Nutrition 131, 2848–2852.CrossRefGoogle ScholarPubMed
Schoeller, DA (1995) Limitations in the assessment of dietary energy intake by self-report. Metabolism 44, Suppl. 2, 18–22.CrossRefGoogle ScholarPubMed
Stubbs, RJ, Harbron, CGM., Murgatroyd, PR & Prentice, AM (1995 a) Covert manipulation of dietary fat and energy density: effect on substrate flux and food intake in men eating ad libitum. American Journal of Clinical Nutrition 62, 316–329.CrossRefGoogle ScholarPubMed
Stubbs, RJ, Ritz, P, Coward, WA & Prentice, AM (1995 b) Covert manipulation of the ratio of dietary fat to carbohydrate and energy density: effect on food intake and energy balance in free-living men eating ad libitum. American Journal of Clinical Nutrition 62, 330–337.CrossRefGoogle ScholarPubMed
Tuomilehto, J, Lindstrom, J, Eriksson, JG, Valle, TT, Hamalainen, H, Ilanne-Parikka, P, Seinanen-Kiukaanniemi, SK, Laakso, M, Louheranta, A, Rastas, M, Salminen, V & Uusitupa, M (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine 344, 1343–1350.CrossRefGoogle ScholarPubMed
UK Prospective Diabetes Study Group (1998 a) United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. Annals of Internal Medicine 128, 165–175.CrossRefGoogle Scholar
UK Prospective Diabetes Study Group (1998 b) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837–853.CrossRefGoogle Scholar
Wardlaw, GM, Snook, JT, Park, S, Patel, PK, Pendley, FC, Lee, M & Jandacek, RJ (1994) Relative effects on serum lipids and apoli-poproteins of a caprenin-rich diet compared with diets rich in palm oil/palm-kernel oil or butter. American Journal of Clinical Nutrition 61, 535–542.CrossRefGoogle Scholar
Westerterp, KR (1998) The assessment of energy and nutrient intake in humans. In Physical Activity and Obesity, pp. 133–149 [Bouchard, c, editor]. Champaign, IL: Human Kinetics.Google Scholar
Willett, W (1990) Nutritional Epidemiology. New York: Oxford University Press.Google Scholar
Wing, RR & Hill, JO (2001) Successful weight loss maintenance. Annual Reviews of Nutrition 21, 323–341.CrossRefGoogle ScholarPubMed
Zemel, MB, Shi, H, Greer, B, Dirienzo, D & Zemel, PC (2000) Regulation of adiposity by calcium. FASEB Journal 14, 1132–1138.CrossRefGoogle ScholarPubMed