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Biochemical responses of broiler chicks to folate deficiency

Published online by Cambridge University Press:  09 March 2007

J. Sarah Rennie ,
Colin C. Whitehead  and
John Armstrong
J. Sarah Rennie
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
Colin C. Whitehead
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
John Armstrong
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
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Abstract

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The effects of folate sufficiency and deficiency in three pathways of folate metabolism were studied in 2- and 3-week-old broiler chicks. Erythrocyte phosphoribosylpyrophosphate concentrations and dihydro- folate reductase (EC 1.5.1.3) activity were significantly elevated in folate deficiency. Percentage incorporation of deoxyuridine into bone marrow DNA was reduced in folate deficiency. There was a trend towards reduced liver dihydrofolate reductase activity in deficient chicks. These studies identify further biochemical criteria that can be used to assess folate status of chicks.

Keywords

Folic acidDihydrofolate reductaseDeoxyuridine suppressionPhosphoribosylpyrophosphateChicken
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 3 , May 1993 , pp. 801 - 808
Copyright
Copyright © The Nutrition Society 1993

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