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Behavioural and cognitive effects of oligofructose-enriched inulin in rats

Published online by Cambridge University Press:  08 March 2007

Michaël Messaoudi ,
Pascale Rozan ,
Amine Nejdi ,
Sophie Hidalgo  and
Didier Desor
Michaël Messaoudi*
Affiliation:
ETAP – Ethologie Appliquée, Technopôle de Nancy-Brabois, 13 rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France
Pascale Rozan
Affiliation:
ETAP – Ethologie Appliquée, Technopôle de Nancy-Brabois, 13 rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France
Amine Nejdi
Affiliation:
ETAP – Ethologie Appliquée, Technopôle de Nancy-Brabois, 13 rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France
Sophie Hidalgo
Affiliation:
ETAP – Ethologie Appliquée, Technopôle de Nancy-Brabois, 13 rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France
Didier Desor
Affiliation:
Laboratoire de Neurosciences Comportementales, Faculté des Sciences, Université Henri Poincaré, 54500 Vandoeuvre-lès-Nancy, France
*
*Corresponding author: Dr Michaël Messaoudi, fax + 33 383 446 441, email [email protected]
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Abstract

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The behavioural and cognitive effects of oligofructose-enriched inulin at the doses of 5 and 10% in the diet, orally ingested daily during 2 weeks, wereinvestigated using a functional observational battery (FOB) and the light extinction test in male Wistar rats. Control rats received a standard diet and were tested in the same test situations. The behavioural effects were assessed 2 d before and 14 d after the beginning of the treatment period and the cognitive effects were investigated after the administration period by lever-pressing activity and learning discrimination using the light extinction test paradigm. In general, the study demonstrated that oligofructose-enriched inulin at 5% in the diet, and particularly at 10% in the diet, caused relaxing-like effects, stimulated and increased the general activity and interest of the rats to the test environment. In addition, both doses of oligofructose-enriched inulin showed significant effects on learning discrimination in male rats, in comparison with the control diet. These results suggest that oligofructose-enriched inulin, particularly at the dose of 10 %, improves cognitive performances in the light extinction test and the well-being of male rats using the FOB.

Keywords

Oligofructose-enriched inulinCognitionLearningLight extinction testRat
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue S1 , April 2005 , pp. S27 - S30
Copyright
Copyright © The Nutrition Society 2005

References

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