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Ascorbic acid concentration of human fetal tissues in relation to fetal size and gestational age

Published online by Cambridge University Press:  09 March 2007

Sunita Zalani
Affiliation:
Department of Biochemistry, Faculty of Science, M.S. University, Baroda, India
R. Rajalakshmi
Affiliation:
Department of Biochemistry, Faculty of Science, M.S. University, Baroda, India
L. J. Parekh
Affiliation:
Department of Biochemistry, Faculty of Science, M.S. University, Baroda, India
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Abstract

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1. Studies were carried out on the distribution of ascorbic acid in human fetal tissues with the progress of gestation.

2. Fetuses and stillborn babies varying in gestational age from 12 to 38 weeks were obtained from various Baroda hospitals. Ascorbic acid levels were determined in selected tissues: brain, adrenal, liver, kidney, lung, heart and placenta.

3. Ascorbic acid concentration in the brain was higher than that in the adrenal at all gestational ages, suggesting the importance of this vitamin in brain development. The concentrations of this vitamin in liver, kidney, lung and placenta were comparable, but that in the heart tended to be lower. In all the tissues, there was a fall in ascorbic acid during late gestation. However, the levels in tissues of stillborn babies were higher than those reported for adults.

Type
Vitamins
Copyright
Copyright © The Nutrition Society 1989

References

Adlard, B. P. F., Desouza, S. W. & Moon, S. (1974). Ascorbic acid in fetal human brain. Archives of Disease in Childhood 49, 278282.CrossRefGoogle ScholarPubMed
Bessey, O. A. & King, C. G. (1933). The distribution of vitamin C in plant and animal tissues and its determination. Journal of Biological Chemistry 103, 687698.CrossRefGoogle Scholar
Dancis, J., Money, W. L., Springer, D. & Levitz, M. (1968). Transport of amino acids by placenta. American Journal of Obstetrics and Gynecology 101, 820829.CrossRefGoogle ScholarPubMed
Edgar, J. A. (1970). Dehydroascorbic acid and cell division. Nature 227, 2426.CrossRefGoogle ScholarPubMed
Friedman, S. & Kaufman, S. (1965). 3,4-Dihydroxyphenylethylamine β-hydroxylase. Journal of Biological Chemistry 240, 47634773.CrossRefGoogle Scholar
Gruenwald, P. G. (1966). Growth of the human fetus: normal growth and its variations. American Journal of Obstetrics and Gynecology 94, 11121119.CrossRefGoogle Scholar
Hammarstrom, L. (1966). Autoradiographic studies on the distribution of C14 labelled ascorbic acid and dehydroascorbic acid. Acta Physiologica Scandinavica 70, Suppl. 289, 84 pp.CrossRefGoogle Scholar
Hornig, D. (1975). Distribution of ascorbic acid, metabolites and analogues in man and animals. Annals of the New York Academy of Sciences 258, 103118.CrossRefGoogle Scholar
Iyengar, L. & Apte, S. V. (1972). Nutrient stores in human foetal livers. British Journal of Nutrition 27, 313317.CrossRefGoogle ScholarPubMed
Lakshminarayan, P., Nagaswamy, S. & Balagopala, R. V. (1974). Foetal growth as assessed by anthropometric measurements. Indian Pediatrics 11, 803810.Google Scholar
Lanman, J. (1962). An interpretation of human foetal adrenal structure and function. In The Human Adrenal Cortex pp. 547557 [Currie, A. R., Symington, T. and Grant, J. K., editors]. Baltimore: Williams and Wilkins.Google Scholar
Longo, L. D., Yuen, P. & Gusseck, D. J. (1973). Anaerobic, glycogen-dependent transport of amino acids by the placenta. Nature 243, 531533.CrossRefGoogle ScholarPubMed
Milby, K., Oke, A. & Adams, R. N. (1982). Detailed mapping of ascorbate distribution in rat brain. Neuroscience Letters 28, 1520.CrossRefGoogle ScholarPubMed
Rajalakshmi, R. & Ramakrishnan, C. V. (1969). Gestation and Lactation Performance in Relation to Nutritional Status. Terminal Report of PL 480 Research Project FG-IN-224, Biochemistry Department, M.S. University, Baroda.Google Scholar
Rajalakshmi, R., Subbulakshmi, G. & Kothari, B. (1974). Ascorbic acid metabolism during pregnancy and lactation. Baroda Journal of Nutrition 1, 117134.Google Scholar
Roe, J. H. & Kuether, C. A. (1943). The determination of ascorbic acid in whole blood and urine through the 2,4- dinitrophenylhydrazine derivative of dehydro-ascorbic acid. Journal of Biological Chemistry 147, 399407.CrossRefGoogle Scholar
Rosso, P. & Norkus, E. (1976). Prenatal aspects of ascorbic acid metabolism in the albino rat. Journal of Nutrition 106, 767770.CrossRefGoogle ScholarPubMed
Schaus, R. (1957). The ascorbic acid content of human pituitary, cerebral cortex, heart and skeletal muscle and its relation to age. American Journal of Clinical Nutrition 5, 3941.CrossRefGoogle ScholarPubMed
Schneider, W. C. (1957). Determination of nucleic acids in tissues by pentose analysis. In Methods in Enzymology Vol. 3, pp. 680684 [Colowick, S. P. and Kaplan, N. O., editors]. New York: Academic Press.Google Scholar
Shimizu, N., Matsunami, T. & Onishi, S. (1960). Histochemical demonstration of ascorbic acid in the locus coeruleus of the mammalian brain. Nature 186, 479480.CrossRefGoogle ScholarPubMed
Subbulakshmi, G. (1970). Studies on pregnancy and lactation. PhD Thesis, M.S. University, Baroda, India.Google Scholar
Thompson, A. M., Billewicz, W. Z. & Hytten, F. E. (1968). The assessment of fetal growth. Journal of Obstetrics and Gynaecology of the British Commonwealth 75, 903916.CrossRefGoogle Scholar
Toverud, K. U., Stearns, G. & Macy, I. G. (1950). Maternal nutrition and child health. Bulletin of the National Academy of Sciences no. 123. Washington DC: National Academy of Sciences.Google Scholar
Vobecky, J. S., Vobecky, J., Shapcott, D., Demers, P. P., Cloutier, D., Blanchard, R. & Fisch, C. (1982). Biochemical indices of nutritional status in maternal, cord and early neonatal blood. American Journal of Clinical Nutrition 36, 630642.CrossRefGoogle ScholarPubMed
Widdowson, E. M. (1968). Growth and composition of the fetus and newborn. In Biology of Gestation Vol. 2. pp. 149 [Assali, N. S. editor]. New York: Academic Press.Google Scholar
Yavorsky, M., Almaden, P. & King, C. G. (1937). The vitamin C content of human tissues. Journal of Biological Chemistry 106, 525529.CrossRefGoogle Scholar
Yeasting, R. (1986). Selected morphological aspects of human suprarenal glands. In The Adrenal Gland pp. 4564 [Murlow, P. J. editor]. New York: Elsevier.Google Scholar