Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-23T02:02:41.443Z Has data issue: false hasContentIssue false
  • English
  • Français

Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats

Published online by Cambridge University Press:  08 March 2007

Zainab M. Al-Amin ,
Martha Thomson ,
Khaled K. Al-Qattan ,
Riitta Peltonen-Shalaby  and
Muslim Ali
Zainab M. Al-Amin
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, 13060-Safat, Kuwait
Martha Thomson
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, 13060-Safat, Kuwait
Khaled K. Al-Qattan
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, 13060-Safat, Kuwait
Riitta Peltonen-Shalaby
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, 13060-Safat, Kuwait
Muslim Ali*
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, 13060-Safat, Kuwait
*
*Corresponding author: Dr Muslim Ali, fax +965 4847054, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied in rats. An aqueous extract of raw ginger was administered daily (500 mg/kg, intraperitoneally) for a period of 7 weeks to streptozotocin (STZ)-induced diabetic rats. Fasting blood serum was analysed for blood glucose, cholesterol and triacylglycerol levels. The STZ-injected rats exhibited hyperglycaemia accompanied with weight loss, indicating their diabetic condition. At a dose of 500 mg/kg, raw ginger was significantly effective in lowering serum glucose, cholesterol and triacylglycerol levels in the ginger-treated diabetic rats compared with the control diabetic rats. The ginger treatment also resulted in a significant reduction in urine protein levels. In addition, the ginger-treated diabetic rats sustained their initial weights during the treatment period. Moreover, ginger decreased both water intake and urine output in the STZ-induced diabetic rats. The present results indicate that raw ginger possesses hypoglycaemic, hypocholesterolaemic and hypolipidaemic potential. Additionally, raw ginger is effective in reversing the diabetic proteinuria observed in the diabetic rats. Thus, ginger may be of great value in managing the effects of diabetic complications in human subjects.

Keywords

Anti-diabetic propertiesDiabetesGingerHypoglycaemic propertiesHypolipidaemic propertiesProteinuria
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 4 , October 2006 , pp. 660 - 666
Copyright
Copyright © The Nutrition Society 2006

References

Abdel-Aziz, H, Nahrstedt, A, Peterelt, F, Windeck, T, Ploch, M & Verspohl, EJ (2005) 5-HT3 receptor blocking activity of arhyalkanes isolated from the rhizome of Zingiber officinale. Planta Med 71, 609–616.CrossRefGoogle ScholarPubMed
Akhani, SP, Vishwakarma, SL & Goyal, RK (2004) Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 56, 101–105.CrossRefGoogle ScholarPubMed
Alnaqeeb, MA, Thomson, M, Al-Qattan, KK, Kamel, F, Mustafa, T & Ali, M (2003) Biochemical and histopathological toxicity of ginger ( Zingiber officinale ) in rats. Kuwait J Sci Eng 30, 35–48.Google Scholar
Axler, DA (1982) Stability of the diabetogenic activity of streptozotocin. IRCS Med Sci 10, 157–165.Google Scholar
Bailey, CJ & Day, C (1989) Traditional plant medicines as treatments for diabetes. Diabetes Care 12, 553–564.CrossRefGoogle ScholarPubMed
Bailey, CJ & Flatt, PR (1990) New Antidiabetic Drugs, London: Smith-GordonGoogle Scholar
Bhandari, U, Kanojia, R & Pillai, KK (2005) Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol 97, 227–230.CrossRefGoogle ScholarPubMed
Bliddal, H, Rosetzsky, A, Schlichting, P, Weidner, MS, Andersen, LA, Ibfelt, H-H, Christensen, K, Jensen, ON & Barslev, J (2000) A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 8, 9–12.CrossRefGoogle ScholarPubMed
Bordia, A, Verma, SK & Srivastava, KC (1997) Effect of ginger ( Zingiber officinale Rosc.) and fenugreek ( Tringonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostagl Leukotr Essen Fatty Acids 56, 379–384.CrossRefGoogle ScholarPubMed
Bradford, M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254.CrossRefGoogle Scholar
Cady, RK, Schreiber, CP, Beach, ME & Hart, CC (2005) Gelstat Migraine ® (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. Med Sci Monit 11, 165–169.Google ScholarPubMed
Chevallier, A (1996) The Encyclopedia of Medicinal Plants. London: Dorling Kindersley Ltd.Google Scholar
Chua, DY & Bakris, GL (2004) Diabetes and chronic kidney disease: tragedy and challenge. Blood Purif 22, 130–135.CrossRefGoogle ScholarPubMed
Clark, CM & Lee, DA (1995) Drug therapy: prevention and treatment of complications of diabetes mellitus. N Engl J Med 332, 1210–1217.CrossRefGoogle ScholarPubMed
Ernst, E & Pittler, MH (2000) Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Brit J Anaes 84, 367–371.CrossRefGoogle ScholarPubMed
Fuhrman, B, Rosenblat, M, Hayek, T, Coleman, R & Aviram, M (2000) Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr 130, 1124–1131.CrossRefGoogle ScholarPubMed
Govindarajan, VS (1982 a) Ginger – chemistry, technology, and quality evaluation: part 1. Crit Rev Food Sci Nutr 17, 1–96.CrossRefGoogle ScholarPubMed
Govindarajan, VS (1982 b) Ginger – chemistry, technology, and quality evaluation: part 2. Crit Rev Food Sci Nutr 17, 189–258.CrossRefGoogle ScholarPubMed
Grant, KI (2000) Ginger. Am J Heath Syst Pharm 57, 945–947.CrossRefGoogle ScholarPubMed
Gray, AM & Flatt, PR (1997) Nature's own pharmacy: the diabetes perspective. Proc Nutr Soc 56, 507–517.CrossRefGoogle ScholarPubMed
Gray, AM & Flatt, PR (1999) Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr 81, 203–209.CrossRefGoogle ScholarPubMed
Hill, JO & Peters, JC (2002) Biomarkers and functional foods for obesity and diabetes. Br J Nutr 88, Suppl.S213–S218.CrossRefGoogle ScholarPubMed
Huang, QR, Iwanmoto, M, Aoki, S, Tanaka, N, Tajima, K, Yamahara, J, Takaishi, Y, Yoshida, M, Tomimatsu, T & Tamai, Y (1991) Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger. Chem Pharm Bull (Tokyo) 39, 397–399.CrossRefGoogle ScholarPubMed
Kar, A, Choudhary, BK & Bandyopadhyay, NG (2003) Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 84, 105–108.CrossRefGoogle ScholarPubMed
Kim, E-C, Min, J-K, Kim, T-Y, Lee, S-J, Yang, H-O, Han, S, Kim, Y-M, Kwon, Y-G (2005) [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Comm 335, 300–308.CrossRefGoogle ScholarPubMed
Kiuchi, F, Iwakami, S, Shibuya, M, Hanaoka, F & Sankawa, U (1992) Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo) 40, 387–391.CrossRefGoogle ScholarPubMed
Koda-Kimble, MA & Carlisle, BA (1995) Diabetes mellitus. In Applied Therapeutics: the Clinical Use of Drugs, 6th ed. 48-1–48–58 [Young, LY, Koda-Kimble, MA, Kradjan, WA and Guglielmo, BJ, editors]. Vancouver, BC, Canada: Applied TherapeuticsGoogle Scholar
McKenna, DJ, Jones, K, Hughes, K & Humphrey, S (2002) Ginger. In Botanical Medicines, the Desk Reference for Major Herbal Supplements, 2nd ed. pp. 411–444New York: The Haworth Herbal PressGoogle Scholar
Mascolo, N, Jain, R, Jain, SC & Capasso, F (1989) Ethnopharmacologic investigation of ginger ( Zingiber officinale ). J Ethnopharmacol 27, 129–140.CrossRefGoogle ScholarPubMed
Mustafa, T & Srivastava, KC (1990) Ginger ( Zingiber officinale ) in migraine headache. J Ethnopharmacol 29, 267–273.CrossRefGoogle ScholarPubMed
Mustafa, T, Srivastava, KC & Jensen, KB (1994) Drug development report (9): Pharmacology of ginger, Zingiber officinale. J Drug Dev 6, 25–39.Google Scholar
National, Research Council (1996) Veterinary medical care. In Guide for the Care and Use of Laboratory Animals, pp. 56–70Washington, DC: National Academy PressGoogle Scholar
Nathan, DM (1993) Long-term complications of diabetes mellitus. N Engl J Med 328, 1676–1685.CrossRefGoogle ScholarPubMed
Penna, SC, Medeiros, MV, Aimbire, FS, Faria-Neto, HC, Sertie, JA, Lopes-Martins, RA (2003) Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomed 10, 381–385.CrossRefGoogle ScholarPubMed
Portnoi, G, Chng, LA, Karimi-Tabesh, L, Koren, G, Tan, MP & Einarson, A (2003) Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 189, 1374–1377.CrossRefGoogle ScholarPubMed
Sharma, M & Shukla, S (1977) Hypoglycaemic effect of ginger. J Res Ind Yoga Homeop 12, 127–130.Google Scholar
Singhal, PC & Joshi, LD (1983) Glycaemic and cholesterolemic role of ginger and till. J Sci Res Plants Med 4, 32–34.Google Scholar
Srinvasan, K (2005) Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr 56, 399–414.CrossRefGoogle Scholar
Srivastava, KC & Mustafa, T (1989) Ginger ( Zingiber officinale ) and rheumatic disorders. Med Hyp 29, 25–28.CrossRefGoogle ScholarPubMed
Srivastava, KC & Mustafa, T (1992) Ginger ( Zingiber officinale ) in rheumatism and musculoskeletal disorders. Med Hyp 39, 342–348.CrossRefGoogle ScholarPubMed
Swanston-Flatt, SK, Flatt, PR, Day, C & Bailey, CJ (1991) Traditional dietary adjuncts for the treatment of diabetes mellitus. Proc Nutr Soc 50, 641–651.CrossRefGoogle ScholarPubMed
Thomson, M, Al-Qattan, KK, Al-Sawan, SM, Alnaqeeb, MA, Khan, I & Ali, M (2002) The use of ginger ( Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostagl Leukotr Essen Fatty Acids 67, 475–478.CrossRefGoogle ScholarPubMed
Ursell, A (2000) The Complete Guide to Healing Foods, pp. 112–114London: Dorling Kindersley Ltd.Google Scholar
Viberti, GC, Hill, RD, Jarett, RJ, Argyropolous, A, Mahmud, U & Kern, H (1982) Microalbuminuria as a predictor of clinical nephropathy in insulin dependent diabetes mellitus. Lancet i, 1430CrossRefGoogle Scholar
Weidner, M & Sigwart, K (2000) The safety of a ginger extract in the rat. J Ethnopharmacol 73, 513–520.CrossRefGoogle ScholarPubMed
White, DA & Baxter, M (1994) Diabetes mellitus Hormones and Metabolic Control, 2nd ed.. pp. 79–92 [White, DA and Baxter, M, editors] London: ArnoldGoogle Scholar
World Health Organization (1980) World Health Organization Expert Committee on Diabetes Mellitus, Second Report Technical Report Series,Geneva:WHO.Google Scholar
Yamada, J, Sugimoto, Y & Inoue, K (1999) Selective serotonin reuptake inhibitors fluoxetine and fluvosamine induce hyperglycemia by different mechanisms. Eur J Pharmacol 382, 211–215.CrossRefGoogle ScholarPubMed