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Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2)

Published online by Cambridge University Press:  09 March 2007

Nanaya Tamaki ,
Shigeko Fujimoto-Sakata ,
Mariko Kikugawa ,
Masae Kaneko ,
Satomi Onosaka  and
Tatsuya Takagi
Nanaya Tamaki
Affiliation:
Faculty of Nutrition, Kobe Gakuin University, Arise, Igawadani, Nishi-ku, Kobe 651–21, Japan
Shigeko Fujimoto-Sakata
Affiliation:
Faculty of Nutrition, Kobe Gakuin University, Arise, Igawadani, Nishi-ku, Kobe 651–21, Japan
Mariko Kikugawa
Affiliation:
Faculty of Nutrition, Kobe Gakuin University, Arise, Igawadani, Nishi-ku, Kobe 651–21, Japan
Masae Kaneko
Affiliation:
Faculty of Nutrition, Kobe Gakuin University, Arise, Igawadani, Nishi-ku, Kobe 651–21, Japan
Satomi Onosaka
Affiliation:
Faculty of Nutrition, Kobe Gakuin University, Arise, Igawadani, Nishi-ku, Kobe 651–21, Japan
Tatsuya Takagi
Affiliation:
Genome Information Research Center, Osaka University, Yamadaoka 3-1, Suita 565, Japan
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Abstract

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The body weight and feed intake of rats fed on a Zn-deficient diet for 28 d were reduced compared with those of control rats. The feed intakes of the Zn-deficient and control groups during the period were 10·2 (SE 0·3) and 15·7 (SE 0·2) g/d respectively. Cyclic variations in feed intake and body-weight changes were found in analysis not only of all the data for five rats but also that in each individual rat. Cosinor analysis revealed that the cyclical period of both the feed intake and body-weight change in the Zn-deficient rats was 3·5 (SE 0·1) d. The mesor and amplitude value of the feed intake in the Zn-deficient rats was 10 1 (SE 0·4) g/d and 3·5 (SE 0·5) g/d respectively, and that of body-weight change was 1·4 (SE 0·1) g/d and 7·9 (SE 1·3) gObihiro d respectively. Among pyrimidine-catabolizing enzymes, dihydropyrimidinase (EC3.5.2.2) activity showed significantretardation in the Zn-deficient rat liver with decrease of the enzyme protein. The ratio of apo-form to holo-form dihydropyrimidinase in the liver was not affected by the Zn-deficient diet.

Keywords

Zinc deficiencyCosinor analysisDihydropyrimidinase
Type
Effects of dietary zinc deficiency
Information
British Journal of Nutrition , Volume 73 , Issue 5 , May 1995 , pp. 711 - 722
Copyright
Copyright © The Nutrition Society 1995

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