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An experimental design to study colonic fibre fermentation in the rat: the duration of feeding

Published online by Cambridge University Press:  09 March 2007

Deborah J. Walter ,
M. A. Eastwood ,
W. G. Brydon  and
R. A. Elton
Deborah J. Walter
Affiliation:
Wolfson Laboratories, Gastrointestinal Unit, Department of Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
M. A. Eastwood
Affiliation:
Wolfson Laboratories, Gastrointestinal Unit, Department of Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
W. G. Brydon
Affiliation:
Wolfson Laboratories, Gastrointestinal Unit, Department of Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
R. A. Elton
Affiliation:
Medical Computing and Statistics Unit, Faculty of Medicine, University of Edinburgh, Teviot Place, Edinburgh
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Abstract

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1. The time-course of metabolic adaptation by rats to diets containing either wheat bran or gum arabic was studied during a 12-week period.

2. Stool weight was increased with wheat bran but not with gum arabic, and had stabilized after 4 weeks.

3. Bacterial mass as measured by diaminopimelic acid content had stabilized by week 4. Bacterial mass increased on feeding gum arabic but was unchanged with wheat bran.

4. There was increased caecal short-chain fatty acid, hydrogen and methane production with gum arabic but not with wheat bran. The change in caecal metabolic activity was slow to stabilize (8–12 weeks at least).

5. The faecal excretion of bile acids increased twofold with the wheat-bran-supplemented diet compared with the gum-arabic-supplemented and unsupplemented diets. Relatively greater amounts of muricholic acids were present in the caeca and faeces of gum-arabic-fed rats compared with the other groups.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 3 , May 1986 , pp. 465 - 479
Copyright
Copyright © The Nutrition Society 1986

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