Hostname: page-component-745bb68f8f-kw2vx Total loading time: 0 Render date: 2025-01-08T10:13:26.928Z Has data issue: false hasContentIssue false
  • English
  • Français

Alcohol and high-density-lipoprotein cholesterol:a randomized controlled trial

Published online by Cambridge University Press:  09 March 2007

Michael L. Burr ,
Ann M. Fehily ,
Barbara K. Butland ,
Colin H. Bolton  and
Robert D. Eastham
Michael L. Burr
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Ann M. Fehily
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Barbara K. Butland
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Colin H. Bolton
Affiliation:
Department of Medicine, University of Bristol, Bristol
Robert D. Eastham
Affiliation:
Department of Haematology, Frenchay Hospital, Bristol
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A randomized controlled trial of cross-over design was set up to examine the effect of alcohol on blood lipids and certain haematological variates relevant to ischaemic heart disease.

2. One hundred subjects drank some alcohol for 4 weeks (mean intake 18.4 g/d) and abstained totally for 4 weeks, the order of these periods being randomized.

3. Alcohol appeared to produce a rise of 7% in serum high-density-lipoprotein(HDL) cholesterol, probably due to a rise in the HDL2 subfraction.

4. No significant change was detected in plasma fibrinogen or the other haematoiogical indices.

5. These results are consistent with the hypothesis that a moderate intake of alcohol confers some protection against heart disease.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 1 , July 1986 , pp. 81 - 86
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Belfrage, P., Berg, B., Hagerstrand, I., Nilson-Ehle, P., Tornqvist, H. & Wiebe, T. (1977). European Journal of Clinical Investigation 7, 127–131.CrossRefGoogle Scholar
Berg, B. & Johansson, B. G. (1973). Acta Medica Scandinavica Suppl. 552, 13–18.CrossRefGoogle Scholar
Eyre, J., Hammett, F. & Miller, N. E. (1981). Clinica Chimica Acta 114, 225–232.CrossRefGoogle Scholar
Glueck, C. J., Hogg, E., Allen, C. & Gartside, P. S. (1980). American Journal of Clinical Nutrition 33, 2287–2293.CrossRefGoogle Scholar
Haskell, W. L., Camargo, C., Williams, P. T., Vranizan, K. M., Krauss, R. M., Lindgren, F. T. & Wood, P. D. (1984). New England Journal of Medicine 310, 805–810.CrossRefGoogle Scholar
Hennekens, C.H., Robner, B. & Cole, D. (1978). American Journal of Epidemiology 107, 196–200.CrossRefGoogle Scholar
Hills, M. & Armitage, P. (1979). British Journal of Clinical Pharmacology 8, 7–20.CrossRefGoogle Scholar
Hulley, S. B. & Gordon, S. (1981). Circulation 64, Suppl. III, III-57–III-63.Google Scholar
Klatsky, A. L., Friedman, G. D. & Siegelaub, A. B. (1981). Annals of Internal Medicine 95, 139–145.CrossRefGoogle Scholar
Kozarareric, D., McGee, D., Vojrodic, N., Racic, Z., Dawber, T., Gordon, T. & Zukel, W. (1980). Lancet i, 613–616.CrossRefGoogle Scholar
Lopes-Virella, M. F., Stone, P., Ellis, S. & Colwell, J. A. (1977). Clinical Chemistry 23, 882–884.CrossRefGoogle Scholar
Marmot, M. G., Rose, G., Shipley, M. J. & Thomas, B. J. (1981). Lancet i, 580–583.CrossRefGoogle Scholar
Miller, N. E., Hammett, F., Saltissi, S., Rao, S., ven Zeller, H., Coltart, J. & Lewis, B. (1981). British Medical Journal 282 1741–1744.CrossRefGoogle Scholar
St Leger, A. S., Cochrane, A. L. & Moore, F. (1979). Lancet i, 1017–1020.CrossRefGoogle Scholar
Simpson, H. S., Ballantyne, F. C., Packard, C. J., Morgan, H. G. & Shepherd, J. (1982). Clinical Chemistry 28, 2040–2043.CrossRefGoogle Scholar
Thornton, J., Symes, C. & Heaton, K. (1983). Lancet ii, 819–822.CrossRefGoogle Scholar
Thorp, J. M., Horsfall, G. B. & Stone, M. C. (1967). Medical and Biological Engineering 5, 51–56.CrossRefGoogle Scholar
Yano, K., Rhoad, G. G., Kagan, A. & Tillotson, J. (1978). American Journal of Clinical Nutrition 31, 1270–1279.CrossRefGoogle Scholar
Yarnell, J. W. G, Fehily, A. M., Milbank, J., Kubicki, A. J., Eastham, R. & Hayes, T. M. (1983). Journal of Epidemiology and Community Health 37, 137–140.Google Scholar