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Adaptive changes in energy expenditure during mild and severe feed restriction in the rat

Published online by Cambridge University Press:  09 March 2007

Patrick C. Even  and
S. Nicolaïdis
Patrick C. Even
Affiliation:
Laborataire de Neurobiologie des Régulations, C.N.R.S. URA 637, Collége de France, 11 Place M. Berthelot, F75231 Paris Cédex 05, France
S. Nicolaïdis
Affiliation:
Laborataire de Neurobiologie des Régulations, C.N.R.S. URA 637, Collége de France, 11 Place M. Berthelot, F75231 Paris Cédex 05, France
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Abstract

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Using a new-generation open-circuit calorimeter capable of monitoring the cost of activity, and thereby both the real thermic effect of feeding (TEF) and basal metabolism in free-moving freely-feeding rats, we have reassessed the proposal that when food intake is restricted an adaptative reduction in energy expenditure participates in the achievement of energy balance. Total energy expenditure, energy expenditure due to spontaneous activity, TEF, basal energy expenditure and respiratory quotient (RQ) were computed by indirect calorimetry in rats given either a mildly restricted (MR) feed intake for 20–30 d (17 g feed/d) or a severely restricted (SR) feed intake for 1–10 d (4 g feed/d). In MR rats no significant changes in any of the measured variables were observed. In contrast, SR rats exhibited an adaptative reduction in energy expenditure due to a reduced spontaneous activity and probably also due to a reduced basal energy expenditure. On the other hand none of the animals fed on a restricted feed intake showed an adaptative TEF decrease, suggesting that TEF under ad lib. feeding is rather an obligatory process that does not include an adaptative component. Taken together, these results point out that under restricted feeding most of the decrease in energy expenditure is associated with simple passive mechanisms, such as body weight loss, and with the reduced feed intake per se. Only under severe feed restriction can some additional energetic economy be obtained from a possible reduction of basal metabolism, and to some extent from reduced activity.

Keywords

CalorimetryEnergy expenditureThermic effect of feedingRespiratory quotientFeed restriction
Type
Energy Metabolism
Information
British Journal of Nutrition , Volume 70 , Issue 2 , September 1993 , pp. 421 - 431
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Apfelbaum, M. (1978). Adaptation to changes in caloric intake. Proceedings of Food and Nutrifion Sciences 2, 543–559.Google Scholar
Benedict, F. G. & Fox, E. L. (1934). Protein and energy metabolism of wild albino rats during prolonged fasting. American Journal of Physiology 108, 285–294.Google Scholar
Bessard, T., Schutz, Y. & Jequier, E. (1983). Energy expenditure and post-prandial thermogenesis in obese women after weight loss. American Journal of Clinical Nutrition 36, 680–694.CrossRefGoogle Scholar
Boyle, P. C., Storlin, L. H., Harper, A. E. & Keesey, R. E. (1981). Oxygen consumption and locomotor activity during restricted feeding and realimentation. American Journal of Physiology 241, R392–R397.Google ScholarPubMed
Cumming, M. C. & Morrison, S. D. (1960). The total metabolism of rats during fasting and refeeding. Journal of Physiology 100, 219–243.CrossRefGoogle Scholar
Danguir, J. & Nicolaidis, S. (1980). Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis. American Journal of Physiology 238, E307–E312.Google Scholar
Dulloo, A. G. & Girardier, L. (1990). Adaptative changes in energy expenditure during refeeding following low- calorie intake: evidence for a specific metabolic component favoring fat storage. American Journal of Clinical Nutrition 52, 415–420.CrossRefGoogle ScholarPubMed
Even, P., Coulaud, H. & Nicolafdis, S. (1988). Lipostatic and ischymetric mechanisms originate dexfenfluramine induced anorexia. Pharmacology, Biochemistry and Behavior 30, 89–99.Google Scholar
Even, P. & Nicolaidis, S. (1981). Changes in the efficiency of ingestant are a major factor of regulation of energy balance. In The Body Weight Regulatory System: Normal and Disturbed Mechanisms pp. 115–123 [Cioffi, L. A. et al., editors]. New York: Raven Press.Google Scholar
Even, P. & Nicolaidis, S. (1984). Le métabolisme de fond: DCfinition et dispositif de mesure (The background metabolism: definition and measuring device). Compte Rendu des Séances de I' Acadimie des Sciences (Paris) 298, 261–266.Google Scholar
Even, P. & Nicolaïdis, S. (1985). Spontaneous and 2DG induced metabolic changes and feeding: the ischymetric hypothesis. Brain Research Bulletin 14, 429–435.CrossRefGoogle Scholar
Even, P., Perrier, E., Aucouturier, J. L. & Nicola'idis, S. (1991). Utilization of the method of Kalman filtering for the on-line computation of background metabolism in the free-moving free-feeding rat. Physiology and Behavior 49, 177–187.CrossRefGoogle ScholarPubMed
Forsum, E., Hilman, P. E. & Nesheim, M. C. (1981). Effect of energy restriction on total heat production, basal metabolic rate, and specific dynamic action of food in rats. Journal of Nutririon 111, 1691–1697.CrossRefGoogle ScholarPubMed
Harris, R. B. S., Thomas, R. K. & Martin, R. L. (1986). Dynamics of recovery of body composition after over- feeding, food restriction and starvation. Journal of Nufrifion 116, 2536–2546.Google Scholar
Hervey, J. R. & Tobin, G. (1983). Luxuxkonsumption, diet induced thermogenesis and brown fat: a critical review. Clinical Science 64, 7–18.Google Scholar
Heusner, A. A. (1982). Energy metabolism and body size. I. Is the 0.75 mass exponent of Kleiber's equation a statistical artifact? Respiratory Physiology 48, 1–12.CrossRefGoogle Scholar
Heusner, A. A. (1984). Biological similitude: statistical and functional relationships in comparative physiology. American Journal of Physiology 246, R839–R845.Google ScholarPubMed
Hill, J. O., Latiff, A. & DiGirolamo, M. (1985). Effects of variable caloric restriction on utilization of ingested energy in rats. American Journal of Physiology 17, R549–R559.Google Scholar
Hill, J. O., Starling, P. B., Shields, T. W. & Heller, P. A. (1987). Effects of exercise and food restriction on body composition and metabolic rate in obese women. American Journal of Clinical Nutrition 46, 622–630.Google Scholar
Kershaw, T. G., Neame, K. D. & Wiseman, G. (1960). The effect of semistarvation on absorption by the rat small intestine in vitro and in vivo. Journal of Physiology 152, 182–190.Google Scholar
Kleiber, M. (1947). Body size and metabolic rate. Physiological Reviews 7, 511–541.CrossRefGoogle Scholar
Kotler, D. P., Kral, J. G. & Björntorp, P. (1982). Refeeding after a fast in rats: effects on small intestinal enzymes. Americun Journul of Clinical Nutrition 36, 457–462.CrossRefGoogle ScholarPubMed
Lusk, G. (1928). The Elements of the Science of Nutrition, 4th ed. Philadelphia: W. W. Saunders.Google Scholar
McCarter, R. J. & McGee, J. R. (1989). Transient reduction of metabolic rate by food restriction. American Journal of Physiology 257, E175–E179.Google Scholar
McCarter, R. J., Masoro, E. J. & Yu, B. P. (1985). Does food restriction retard aging by reducing metabolic rate? American Journal of Physiology 248: E488–E492.Google Scholar
McNab, B. K. (1963). A model of the energy budget of the wild mouse. Ecology 44, 521–532.Google Scholar
Marrazzi, R. (1940). The influence of adrenalectomy and of fasting on the intestinal absorption of carbohydrates. Ameeican Journal of Physiology 131, 36–42.CrossRefGoogle Scholar
Morrison, S. D. (1968). The constancy of the energy expended by rats on spontaneous activity, and the distribution of activity between feeding and non-feeding. Journal of Physiology 197, 305–323.Google Scholar
Piers, L. S., Soares, M. J. & Shetty, P. S. (1992). Thermic effect of a meal. 2. Role in chronic undernutrition. British Journal of Nutrition 67, 177–185.Google Scholar
Richter, C. P. & Rice, K. K. (1954). Comparison of the effect produced by fasting on gross bodily activity of wild and domesticated Norway rats. American Journal of Physiology 179, 305–308.CrossRefGoogle ScholarPubMed
Rothwell, N. J. & Stock, M. J. (1984). Energy balance, thermogenesis and brown adipose tissue activity in tube- fed rats. Journal of Nutrition 114, 1965–1970.CrossRefGoogle Scholar
Tai, M. M., Castillo, P. & Pi-Sunyer, F. X. (1991). Meal size and frequency: effect on the thermic effect of food. American Journal of Clinical Nutrition 54, 783–787.Google Scholar
Trayhurn, P. & James, W. P. T. (1985). Thermogenesis: dietary and non-shivering aspects. In Body Weight Regulatory System: Normal andDisfurbed Mechanisms. pp. 97–105 [Cioffi, L. A., James, W. P. T. and Van Itallie, T. B., editors]. New York: Raven Press.Google Scholar
Vaisman, N., Rossi, M. F., Corey, M., Clarke, R., Goldberg, E. & Pencharz, P. B. (1991). Effect of refeeding on the energy metabolism of adolescent girls who have anorexia nervosa. European Journal of Clinical Nutrition 45, 527–537.Google Scholar
Waterlow, J. C. (1986). Metabolic adaptation to low intakes of energy and protein. Annual Review of Nutrition 6, 495–526.Google Scholar
Westerterp, K. (1977). How rats economize energy loss in starvation. Physiological Zoology 50, 331–362.Google Scholar
Yu, B. P., Masoro, E. J. & McMahan, C. A. (1985). Nutritional influences on aging of Fisher 344 rats. I. Physical, metabolic and longevity mechanisms. Journal of Gerontology 40, 657–670.CrossRefGoogle Scholar