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Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q10 levels in ICR mice

Published online by Cambridge University Press:  08 March 2007

Hui-Ting Yang ,
Shyh-Hsiang Lin ,
Shih-Yi Huang  and
Hsin-Ju Chou
Hui-Ting Yang
Affiliation:
School of Pharmaceutical Science, Taipei Medical University, Taipei, Taiwan
Shyh-Hsiang Lin
Affiliation:
School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan, 110
Shih-Yi Huang*
Affiliation:
School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan, 110
Hsin-Ju Chou
Affiliation:
School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan, 110
*
*Corresponding author: Dr S.-Y. Huang, fax +886 2 27373112, email [email protected]
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Abstract

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In this study, we attempted to evaluate the effect of administration of a high quantity of red yeast rice on coenzyme Q10 (CoQ10) synthesis in the tissues of ICR mice. Eighty-eight adult male ICR mice were housed and divided into control and experimental groups for red yeast rice treatment. Animals were gavaged with a low (1 g/kg body weight) or a high dose (5 g/kg body weight, approximately five times the typical recommended human dose) of red yeast rice dissolved in soyabean oil. After gavagement, animals of the control group were immediately killed; mice of the experimental groups (eight for each subgroup) were killed at different time intervals of 0·5, 1, 1·5, 4 and 24 h. The liver, heart and kidney were taken for analysis of monacolin K (liver only) and CoQ10 analysis. Liver and heart CoQ10 levels declined dramatically in both groups administered red yeast rice, especially in the high-dose group, within 30 min. After 24 h, the levels of hepatic and cardiac CoQ10 were still reduced. A similar trend was also observed in the heart, but the inhibitory effect began after 90 min. The higher dose of red yeast rice presented a greater suppressive effect than did the lower dose on tissue CoQ10 levels. In conclusion, acute red yeast rice gavage suppressed hepatic and cardiac CoQ10 levels in rodents; furthermore, the inhibitory effect was responsive to the doses administered.

Keywords

Red yeast riceCoenzyme Q10Monacolin KGavagement
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 1 , January 2005 , pp. 131 - 135
Copyright
Copyright © The Nutrition Society 2004

References

Aniya, Y, Yokomakura, T, Yonamine, M, Shimada, K, Nagamine, T, Shimabukuro, M & Gibo, H (1999) Screening of antioxidant action of various molds and protection of Monascus anka against experimentally induced liver injuries of rats. Gen Pharmacol 32, 225–231.CrossRefGoogle ScholarPubMed
Appelkvist, EL, Edlund, C, Low, P, Schedin, S, Kalen, A & Dallner, G (1993) Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosynthesis. Clin Investig 71, S97–S102.Google Scholar
Ashton, E, Liew, D & Krum, H (2003) Should patients with chronic heart failure be treated with ‘statins’?. Heart Fail Monit 3, 82–86.Google Scholar
Chagas, GM, Oliveira, MBM, Campello, AP, Klüppel, MLW (1995) Mechanism of citrinin-induced dysfunction of mitochondria. IV. Effect on Ca 2+ transport. Cell Biochem Funct 13, 53–59.CrossRefGoogle Scholar
Crane, FL (2001) Biochemical functions of coenzyme Q 10. J Am Coll Nutr 20, 591–598.Google Scholar
Davidson, M, McKenney, J, Stein, E, Schrott, H, Bakker-Arkema, R, Fayyad, R & Black, D (1997) Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin Study Group I. Am J Cardiol 79, 1475–1481.Google Scholar
Edlund, PO (1988) Determination of coenzyme Q 10, alpha-tocopherol and cholesterol in biological samples by coupled-column liquid chromatography with colometric and ultraviolet detection. J Chromatogr 425, 87–97.Google Scholar
Ghirlanda, G, Oradei, A, Manto, A, Lippa, S, Uccioli, L, Caputo, S, Greco, AV & Littarru, GP (1993) Evidence of plasma CoQ 10 -lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol 33, 226–229.CrossRefGoogle ScholarPubMed
Heber, D, Yip, I, Ashley, JM, Elashoff, DA, Elashoff, RM & Go, VL (1999) Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 69, 231–236.CrossRefGoogle ScholarPubMed
International Agency for Research on Cancer (1986) Some Naturally Occurring and Synthetic Food Components, Coumarins and Ultraviolet Radiation. Monographs of the Evaluation of the Carcinogenic Risk of Chemical to Humans no. 40. 83–98Lyon, France: IARC.Google Scholar
Katan, MB, Grundy, SM, Jones, P, Law, M, Miettinen, T, Paoletti, R & Stresa Workshop Participants (2003) Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965–978.Google Scholar
Kogika, MM, Hagiwara, MK & Mirandola, RM (1993) Experimental citrinin nephrotoxicosis in dogs: renal function evaluation. Vet Hum Toxicol 35, 136–140.Google Scholar
Kontudh, A, Hubner, G, Finckh, B, Kohlschutter, A & Beisiegel, U (1995) Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low-density lipoprotein. Biochim Biophys Acta 1258, 177–187.Google Scholar
Krejci, ME, Bretz, NS & Koechel, DA (1996) Citrinin produces acute adverse changes in renal function and ultrastructure in pentobarbital-anesthetized dogs without concomitant reductions in [potassium] plasma. Toxicology 106, 167–177.Google Scholar
Laaksonen, R, Ojala, JP, Tikkanen, MJ & Himberg, JJ (1994) Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors. Eur J Clin Pharmacol 46, 313–317.Google Scholar
Lockard, VG, Phillips, RD, Hayes, AW, Berndt, WO, O'Neal, RM (1980) Citrinin nephrotoxicity in rats: a light and electron microscopic study. Exp Mol Pathol 32, 226–240.CrossRefGoogle ScholarPubMed
Mohe, D, Bowry, VW & Stocker, R (1992) Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126, 247–254.Google Scholar
Mortenson, SA, Leth, A, Agner, E & Rhode, M (1997) Dose-related decrease of serum coenzyme Q 10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 18, S137–S144.CrossRefGoogle Scholar
Okamoto, T, Fukui, K, Nakamoto, M, Kishi, T, Okishio, T, Yamagami, T, Kanamori, N, Kishi, H & Hiraoka, E (1985) High-performance liquid chromatography of coenzyme Q-related compounds and its application to biological materials. J Chromatogr 342, 35–46.Google Scholar
Ostlund RE, Jr (2002) Phytosterols in human nutrition. Ann Rev Nutr 2, 533–549.Google Scholar
Palomaki, A, Malminiemi, K, Solakivi, T & Malminiemi, O (1998) Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo. J Lipid Res 39, 1430–1437.Google Scholar
Scandinavian Simvastatin Survival Study Group (1994) Randomized trials of cholesterol lowering in 4444 patients with coronary and secondary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 44, 1301–1307.Google Scholar
Schaefer, WH, Lawrence, JW, Loughlin, AF, Stoffregen, DA, Mixson, LA, Dean, DC, Raab, CE, Yu, NX, Lankas, GR & Frederick, CB (2004) Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats. Toxicol Appl Pharmacol 194, 10–23.Google Scholar
Shieh MJ, Jr, Huang, SY, Yang, HT, Liu, PY, Chien, H, Liu, YL, Shieh, MJ (2001) Effects of monascus rice powder on coenzyme Q 10, vitamin E, and fatty acids of low-density lipoprotein in hamster. Nutr Sci J 26, 230–239 (in Chinese).Google Scholar
Wang, J, Su, M & Lu, Z (1995) Clinical trial of extract of Monascus purpureus (red yeast) in the treatment of hyperlipidemia. Chin J Exp Ther Resp Chin Med 12, 1–5.Google Scholar
Watts, GF & Burke, V (1996) Lipid-lowering trials in the primary and secondary prevention of coronary heart disease: new evidence, implications and outstanding tissues. Curr Opin Lipidol 7, 341–355.Google Scholar
Willis, RA, Folkers, K, Tucker, JL, Ye, CQ, Xia, LJ & Tamagawa, H (1990) Lovastatin decreases coenzyme Q levels in rats. Proc Natl Acad Sci USA 87, 8928–8930.Google Scholar
Yamashita, S & Yamamoto, Y (1997) Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem 250, 66–73.Google Scholar
Zhu, Y, Li, CL & Wang, YY (1995) Effects of ‘Xueshikang’ on blood lipids and lipoprotein concentrations of rabbits and quails with hyperlipidemia. Chin J Pharmacol 30, 4–8.Google Scholar
Zhu, Y, Li, CL, Wang, YY, Zhu, JS, Chang, J & Kritchevsky, D (1998) Monascus purpureus (red yeast): a natural product that lowers blood cholesterol in animal models of hypercholesterolemia. Nutr Res 8, 71–81.Google Scholar