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Absorption of very-long-chain saturated fatty acids in totally hydrogenated fish oil

Published online by Cambridge University Press:  09 March 2007

Linda Granlund ,
Laila N. Larsen ,
Erling N. Christiansen  and
Jan I. Pedersen
Linda Granlund
Affiliation:
Institute for Nutrition Research, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
Laila N. Larsen
Affiliation:
Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
Erling N. Christiansen
Affiliation:
Institute for Nutrition Research, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
Jan I. Pedersen*
Affiliation:
Institute for Nutrition Research, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
*
*Corresponding author: Dr Jan I. Pederson, fax +47 22 85 13[email protected]
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Abstract

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Partially hydrogenated fish oil (PHFO) contains a high amount of trans fatty acids (TFA). Total hydrogenation results in a minimal amount of TFA, but a high content of very-long-chain saturated fatty acids (VLCSFA). Absorption and metabolism of VLCSFA from totally hydrogenated fish oil (THFO) were studied in rats. Groups of eight rats were fed one of four diets containing 40 g soyabean oil (SBO)/kg (low-fat diet), 150 g SBO/kg (SBO diet), 40 g SBO+110 g PHFO/kg (PHFO diet) or 40 g SBO+110 g THFO/kg (THFO diet) for 4 weeks. A lower absorption coefficient of the fat content was found in the THFO group (61 %) compared with the other groups (PHFO 95 %, SBO 99 %, low fat 98 %; P<0·05), which was mainly due to reduced absorption of VLCSFA. A reduced weight gain was found for the THFO group compared with the other groups, but this was only significant when compared with the SBO group (P<0·05). Faecal fat excretion (dry weight) was markedly increased in the THFO group (47 %), which was 2·4, 4·8 and 8·3 times higher compared with the groups fed PHFO, SBO and low-fat diets (P<0·05), respectively. Serum total cholesterol was reduced for the PHFO and THFO groups (P<0·05), whereas serum triacylglycerol was increased for the PHFO group compared with the other groups (P<0·05). Animals fed THFO diet had an increased content of 20:0 and 22:0 in the serum triacylglycerol fraction (P<0·05), whereas only 20:0 was increased in the serum phospholipid fraction (P<0·05). The low absorption coefficient of THFO must be considered if this fat is to be used for consumption by animals or man.

Keywords

Dietary fatHydrogenated fish oilBioavailability
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 681 - 688
Copyright
Copyright © The Nutrition Society 2000

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