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Absorption of lactulose from mammalian gastrointestinal tract

Published online by Cambridge University Press:  08 December 2008

D. F. Evered  and
F. Sadoogh-Abasian
D. F. Evered
Affiliation:
Department of Biochemistry, Chelsea College (University of London), Manresa Road, LondonSW3 6LX
F. Sadoogh-Abasian
Affiliation:
Department of Biochemistry, Chelsea College (University of London), Manresa Road, LondonSW3 6LX
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Abstract

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1. The disaccharide lactulose (galactosyl-β-1,4-fructose) was poorly absorbed from rat small intestine in vitro and human mouth in vivo.

2. These results confirm indirect clinical evidence of poor absorption from the intestine.

3. The presence of calcium ions, or absence of sodium ions, had no effect on lactulose absorption from the buccal cavity.

4. The presence of ouabain, or absence of Na+, did not decrease the absorption of lactulose from small intestine.

5. It is thought that the mode of transport, in both instances, is by passive diffusion with the concentration gradient.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 1 , January 1979 , pp. 47 - 51
Copyright
Copyright © The Nutrition Society 1979

References

Beckett, A. H. & Triggs, E. J. (1967). J. Pharm. Pharmac. 19, Suppl.31s.Google Scholar
Birch, G. G. (1973). Confect. Prod. 39, 73.Google Scholar
Crane, R. K. (1968). In Handbook of Physiology, p. 1323 [Code, C. F. & Heidel, W., editors]. Washington, DC: American Physiological Society.Google Scholar
Dahlqvist, A. & Gryboski, J. D. (1965). Biochim. biophys. Acta 110, 635.CrossRefGoogle Scholar
Dawson, R. M. C., Elliott, D. C., Elliott, W. H. & Jones, K. M. (1960). Data for Biochemical Research, 2nd ed., p. 507Oxford: Clarendon Press.Google Scholar
Ghebregzabher, M., Rufini, S., Ciuffini, G. & Lato, M. (1974). J. Chromat. 95, 51.CrossRefGoogle Scholar
Hansen, S. V. (1975). J. Chromat. 107, 224.CrossRefGoogle Scholar
Hendrickse, R. G., Wooldridge, M. A. W. & Russell, A. (1977). Br. med. J. 1, 1194.CrossRefGoogle Scholar
Laker, M. F. & Menzies, I. S. (1977). J. Physiol., Lond. 265, 881.CrossRefGoogle Scholar
McMullan, J. M., Manning, A. S. & Evered, D. F. (1977). Biochem. Soc. Trans. 5, 129.CrossRefGoogle Scholar
Mahy, B. M. W., Rowson, K. E. K., Salaman, M. H. & Parr, C. W. (1964). Virology 23, 528.CrossRefGoogle Scholar
Manning, A. S. (1977). Specialised studies on the absorption of sugars across the mammalian gastrointestinal tract. PhD Thesis, University of London.Google Scholar
Manning, A. S. & Evered, D. F. (1976). Clin. Sci. mol. Med. 51, 127.Google Scholar
Manning, A. S., McMullan, J. M. & Evered, D. F. (1978). Biochem. Soc. Trans. (In the Press).Google Scholar
Menzies, L. S. (1974). Biochem. Soc. Trans. 2, 1042.CrossRefGoogle Scholar
Pritchard, P. J. & Porteous, J. W. (1977). Biochem. J. 164, 1.CrossRefGoogle Scholar
Schultz, S. G. & Curran, P. J. (1970). Physiol. Rev. 50, 637.CrossRefGoogle Scholar
Spencer, R. P. & Knox, W. E. (1960). Fed. Proc. 19, 886.Google Scholar
Vince, A., Killingley, M. & Wrong, O. M. (1978). Clin. Sci. mol. Med. 54, 33P.Google Scholar