Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-26T22:58:47.307Z Has data issue: false hasContentIssue false
  • English
  • Français

Absorption of iron from ferric hydroxypyranone complexes

Published online by Cambridge University Press:  09 March 2007

D. G. Maxton ,
R. P. H. Thompson  and
R. C. Hider
D. G. Maxton
Affiliation:
Gastrointestinal Laboratory, The Rayne Institute, St Thoinas' Hospital, London SE1 7EH
R. P. H. Thompson
Affiliation:
Gastrointestinal Laboratory, The Rayne Institute, St Thoinas' Hospital, London SE1 7EH
R. C. Hider
Affiliation:
Department of Pharmacy, King's College, University of London, London SW3 60X
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency.

Keywords

IronFerric hydroxypyranoneAnaemiaMan
Type
Absorption of iron pyrone complexes
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 203 - 207
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Barrand, M. A., Callingham, B. A. & Hider, R. C. (1987). Effects of the pyrones, maltol and ethylmaltol, on iron absorption from the rat small intestine. Journal of Pharmacy and Pharmacology 39, 203–211.CrossRefGoogle ScholarPubMed
Crosby, W. H. & O'Neil-Cutting, M. A. (1984). A small dose iron tolerance test as an indicator of mild iron deficiency. Journal of the American Medical Association 251, 1986–1987.CrossRefGoogle ScholarPubMed
Dietzfelbinger, H. (1987). Bioavailability of bi- and trivalent oral iron preparations. Arzneimittel Forschnung 37, 107–112.Google ScholarPubMed
Forth, W. & Rummel, W. (1973). Iron absorption. Physiological Reviews 53, 724–794.CrossRefGoogle ScholarPubMed
Forth, W. & Schafer, S. G. (1987). Absorption of di- and trivalent iron. Arzneimittel Forschnung 37, 96–100.Google ScholarPubMed
Gerard, C. & Hugel, R. P. (1980). Iron complexes of maltol. Journal of Chemica1 Research 3927–3954.Google Scholar
Hallberg, L., Ryttinger, L. & Solvell, L. (1966). Side effects of oral iron therapy. Acta Medica Scandinavica 181,3–10.CrossRefGoogle Scholar
Heinrich, H. C. (1987). Intestinal absorption of 59Fe from neutron-activated commercial oral iron(III)-citrate and iron(III)-hydroxide-polymaltose complexes in man. Arzneimittel Forschnung 37, 105–107.Google ScholarPubMed
Hider, R. C. & Hall, A. D. (1991). Clinically useful chelators of tripositive elements. Progress in Medical Chemistry 28, 41–173.CrossRefGoogle ScholarPubMed
Hurrell, R. F. (1985). In Iron Fortification of Foods, pp. 44–45 [Clydesdale, F. M. and Wiemer, K. L., editors&rsqb. London: Academic Press.Google Scholar
Hurrell, R. F., Furniss, D. E., Burri, J., Whittaker, P., Lynch, S. R. & Cook, J. D. (1989). Iron fortification of infant cereals; a proposal for the use of ferrous fumarate or ferrous succinate. American Journal of Clinical Nutrition 49, 1274–1282.CrossRefGoogle ScholarPubMed
Kelsey, S. M., Hider, R. C., Blair, J. R., Blake, D. R., Gutteridge, C. N. & Newland, A. C. (1991). Absorption of low and therapeutic doses of ferric maltol, a novel ferric iron compound, in iron deficient subjects using a single dose iron absorption test. Journal of Clinical Pharmacy and Therapeutics 16, 117–122.CrossRefGoogle ScholarPubMed
Levey, J. A., Barrand, M. A., Callingham, B. A. & Hider, R. C. (1988). Characteristics of iron(III) uptake by isolated fragments of rat small intestine in the presence of the hydroxypyrones, maltol and ethylmdkol. Biochemical Pharmacology 37, 2051–2057.CrossRefGoogle Scholar
Pagella, P. G., Bellavite, O., Agozzino, S. & Dona, G. C. (1984). Pharmacological and toxicological studies on an iron succinyl-protein complex (ITF282) for oral treatment of iron deficiency anaemia. Arzneimittel Forschnung 34, 952–958.Google Scholar
Rennhard, H. H. (1971). The metabolism of ethyl maltol and maltol in the dog. Journal of Agriculture and Food Chemistry 19, 152–154.CrossRefGoogle Scholar
Schneider, W. (1987). The fate of iron compounds in the gastrointestinal tract. Arzneimittel Forschnung 37, 92–95.Google ScholarPubMed
Slivka, A., Kang, J. & Cohen, G. (1986). Hydroxyl radicals and the toxicity of oral iron. Biochemical Pharmacology 35, 553–556.CrossRefGoogle ScholarPubMed
Stefanovic, A., Havel, J. & Sommer, L. (1968). On the reaction of iron(III) with maltol. Collection of Czechoslovak Chemical Communications 33, 4198–4214.CrossRefGoogle Scholar