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The absorption of [58Co]cyanocobalamin by unweaned rats

Published online by Cambridge University Press:  09 March 2007

D. L. Williams  and
G. H. Spray
D. L. Williams
Affiliation:
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford
G. H. Spray
Affiliation:
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford
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Abstract

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1. ‘58Co’cyanocobalamin was given by stomach tube to Wistar albino rats aged between 6 h and 24 days. The fraction of the dose absorbed was assessed by measuring the amount retained by the animals after 7 days, by total body counting.

2. Rats up to 4 days old absorbed about 90% of the test dose, compared with a mean of 83% at the age of 8 days, 66% at 16 days and 47% at 24 days.

3. The proportion of the test dose absorbed did not appear to be affected by starvation for up to 24 h, by increasing the dose from 0·05 ng to 0·25 ng/g body-weight, or by giving the ‘58Co’cyanocobalamin mixed with rat's milk.

4. The results support earlier suggestions that newborn rats absorb vitamin B12 by a different mechanism from that in adults.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 2 , May 1968 , pp. 297 - 301
Copyright
Copyright © The Nutrition Society 1968

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