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Erythrocyte membrane and breast milk fatty acid profile in lactating mothers: relationship with infant erythrocyte membrane fatty acid profile

Published online by Cambridge University Press:  11 October 2024

Silvana Visentin Open the ORCID record for Silvana Visentin [Opens in a new window] ,
Agustina Malpeli ,
Victoria Fasano ,
Marisa Sala  and
Horacio Federico Gonzalez
Silvana Visentin*
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas ‘Prof. Dr. Fernando E. Viteri’ (Hospital de Niños ‘Sor María Ludovica’ de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), Calle 63 N° 1069 (1900) La Plata, Argentina Cátedra de Posgrado de Nutrición Humana de la Facultad de Ciencias Médicas de la Universidad Nacional de La Plata, Calle 60 y 120, La Plata, Argentina
Agustina Malpeli
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas ‘Prof. Dr. Fernando E. Viteri’ (Hospital de Niños ‘Sor María Ludovica’ de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), Calle 63 N° 1069 (1900) La Plata, Argentina
Victoria Fasano
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas ‘Prof. Dr. Fernando E. Viteri’ (Hospital de Niños ‘Sor María Ludovica’ de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), Calle 63 N° 1069 (1900) La Plata, Argentina Departamento de Matemática, Facultad Ciencias Exactas, Universidad Nacional de La Plata, Calle 115 s/n, La Plata, Argentina
Marisa Sala
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas ‘Prof. Dr. Fernando E. Viteri’ (Hospital de Niños ‘Sor María Ludovica’ de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), Calle 63 N° 1069 (1900) La Plata, Argentina
Horacio Federico Gonzalez
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas ‘Prof. Dr. Fernando E. Viteri’ (Hospital de Niños ‘Sor María Ludovica’ de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), Calle 63 N° 1069 (1900) La Plata, Argentina Cátedra de Posgrado de Nutrición Humana de la Facultad de Ciencias Médicas de la Universidad Nacional de La Plata, Calle 60 y 120, La Plata, Argentina
*
*Corresponding author: Silvana Visentin, email [email protected]
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Abstract

During the first thousand days of life, fetus and infant’s nutrition depends on mother’s diet. Polyunsaturated fatty acids (PUFA) are important substrates in infant neurogenesis. We related erythrocyte membrane (EM) and breast milk fatty acids (FA) profile in lactating mothers with the EM FA profile in exclusively breastfed infants and evaluated maternal fat consumption. We conducted an observational, cross-sectional analytical study. During the 2016–2019 period, milk and blood samples from adult mothers 90 days post-partum and infant’s blood were analysed, and FA were determined by GC. A frequency of consumption survey of fatty acids precursor foods and sources was conducted. The sample included forty-five mother–infant EM and forty-five milk samples donated by the same mothers. A low percentage of DHA (0·14 (0·12–0·2)) was found in milk, consistent with mother’s low consumption of DHA-rich foods. A significant positive correlation between infant’s EM DHA percentage and milk DHA percentage (r = 0·39; P value 0·008), as well as between infant’s EM ω-3 fatty acids sum and milk DHA percentage (r = 0·39; P value 0·008), was found. When milk had a DHA percentage greater than or equal to 0·20 %, infants had a significant increase in DHA in their EM. Mother’s consumption of DHA precursors and sources was NS. The relation between the DHA percentage distribution found in maternal milk, and the DHA percentage distribution found in infant’s and mother’s EM was proven in this population. Dietary fatty acid intake is associated with the maternal milk lipid distribution and with mothers’ and infant’s EM fatty acids percentage.

Keywords

Fatty acids dietHuman milkPolyunsaturated fatty acidsErythrocytes
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 6 , 28 September 2024 , pp. 762 - 769
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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