Formal assessment of the impact of frontal-lobe impairment on social and interpersonal function has been somewhat neglected relative to interest in documenting executive impairment on nonsocial tasks. Despite this, experimental evidence is accruing that attests to the role of the orbitomedial frontal lobes, the amygdala and related structures in the appraisal and interpretation of socially relevant stimuli. In this address the evidence regarding the frontal lobes and social cognition, that is, social information processing is reviewed. At least 3 different constructs have been proposed that appear to be mediated by cerebral systems encompassing the orbitomedial frontal cortex: (1) social schema or social knowledge networks that guide judgments and behavioural responses, (2) emotional processing, including both the ability to recognise different affective states in others and the ability to experience affective (somatic) responses to emotionally important environmental stimuli, and (3) theory of mind – the ability to conceptualise what others are thinking and feeling. On the basis of this recent experimental work it is argued that a variety of assessment techniques are becoming available that are both practical and potentially sensitive to psychosocial changes after frontal lobe damage.