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Fear at the time of the COVID-19 pandemic: validation of the Arabic version of the Four-Dimensional Symptom Questionnaire among Saudi-based respondents

Published online by Cambridge University Press:  12 January 2021

Abdulaziz I Aljemaiah
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Mugtaba Osman*
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Sarah Alharbi
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Randa Alshehri
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Esraa Mansoer Aldggag
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Alaa Talal Aljoudi
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Dina Smail Abdulsomad
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
Mohammed Abdulghani
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia; and Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt
Fawaz Alotaibi
Affiliation:
Armed Forces Center for Psychiatric Care, Taif, Saudi Arabia
*
Correspondence: Mugtaba Osman. Email: [email protected]
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Abstract

Background

The COVID-19 pandemic has caused unprecedented stress and fear throughout the world.

Aims

To evaluate the psychological effects of the COVID-19 pandemic on the Saudi public, and to examine the performance of the Arabic version of the Four-Dimensional Symptom Questionnaire (4DSQ) scale.

Method

We conducted an online questionnaire-based cross-sectional survey of a sample of the Saudi public.

Results

The study included 347 participants, who reported significantly higher levels of distress, depressive symptoms, anxiety symptoms and somatisation compared with a normative sample. Females scored higher in terms of somatisation, depression and anxiety symptoms, and distress. Obtaining COVID-19 information from friends and relatives was associated with higher levels of somatisation, depression and anxiety symptoms, and distress. Cronbach's alpha was 0.93 for the distress scale, 0.88 for the depression scale, 0.88 for the anxiety scale and 0.86 for the somatisation scale.

Conclusions

Levels of psychological distress were high among the Saudi public during the COVID-19 pandemic. We found high reliability for the Arabic version of the 4DSQ scale. However, three items did not conform to the four-factor structure, namely, item 1: ‘During the past week, did you suffer from dizziness or feeling light-headed?’, item 20: ‘During the past week, did you suffer from disturbed sleep?’ and item 46: ‘During the past week did you ever think I wish I was dead?’.

Type
Papers
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists

The COVID-19 pandemic triggered substantial stress, fear and uncertainty all over the world.Reference Smith, Jacob, Yakkundi, McDermott, Armstrong and Barnett1 Deaths exceeded 1.016 million worldwide, and there were more than 34.2 million confirmed cases by 2 October 2020.2 The pandemic resulted in substantial psychological effects, with moderate to severe anxiety and depressive symptoms in over half of the population.Reference Odriozola-González, Planchuelo-Gómez, Irurtia and de Luis-García3 In addition, sleep disruption was reported during the initial phase of the lockdown as people's quality of sleep was severely reduced.Reference Cellini, Canale, Mioni and Costa4 Many people followed physical distancing rules during the lockdown period and believed in their effect of curbing the virus spread.Reference Kochhar, Bhasin, Kochhar, Dadlani, Mehta and Kaur5 That had profound effects on travel plans and work schedules, with subsequent mood deterioration, anxiety and fearfulness.

There is a pressing need to quantify the psychological repercussions of COVID-19, particularly in Middle Eastern countries. The Four-Dimensional Symptom Questionnaire (4DSQ) measures the extent of somatisation, distress, anxiety and depression using established psychometric properties across many cultures and languages.Reference Terluin, Smits and Miedema6,Reference Terluin, Brouwers, Marchand and de Vet7 The 4DSQ Arabic version was developed in 2016 by a group of Egyptian researchers through a procedure of translation of the English version into Arabic and back-translation into English;Reference Samaha, Elsaid and Sabri8 however, no validation study was carried out to examine its reliability and/or factor structure. This study was conducted to achieve two aims. First, to validate the Arabic version of 4DSQ in a Saudi sample during the COVID-19 pandemic. Second, to quantify the epidemiological features of the psychological effects of the COVID-19 pandemic in Saudi Arabia.

Method

Study design

This was a cross-sectional questionnaire-based descriptive study. The study included a self-selected sample of n = 347 respondents, 61.4% male and 38.6% female, with a median age of 35 years, from Taif, Saudi Arabia. The survey was conducted between April and May 2020, the period during which a state-wide curfew and lockdown was imposed, 24 h a day, 7 days a week, to curb the spread of coronavirus. Violators of curfew were subjected to substantial on-the-spot fines. In addition, all air and sea travel to and from the Kingdom of Saudi Arabia was suspended. The Arabic adaptation of the 4DSQ questionnaire was obtained with permission and posted online with an invitation to complete the questionnaire. The link was sent through social media. The Arabic 4DSQ questions were published on an online survey website with a cover letter explaining the purpose of the study and the expected time to complete the survey. An invitation to complete the survey was designed and sent out to all authors involved in the study. The link to the online questionnaire was made available through major social media outlets throughout the study period. The target population was all adult citizens based in Taif.

The 4DSQ tool

The 4DSQ tool, freely available at www.4dsq.eu, has 50 items related to feelings in the past week.Reference Terluin, van Marwijk, Adèr, de Vet, Penninx and Hermens9 The 4DSQ questionnaire investigates four dimensions, with 16 questions each for distress and somatisation, 12 questions for anxiety and six questions for depression. The 4DSQ uses a time-frame reference of 7 days. Each item has a five-point scale response, with options of ‘no’ (zero points), ‘sometimes’ (one point), and ‘regularly’, ‘often’ and ‘very often or constantly’ (two points each). The Arabic version of the 4DSQ was developed later in 2016, but no psychometric analysis was performed. Permission was granted kindly by the main author of the 4DSQ, Dr B. Terluin, to use the Arabic version in our current investigation. The 4DSQ was readily translated from the Dutch language into Arabic under supervision of the original developer of 4SDQ by a group of Egyptian academics. The Arabic version is available freely from www.4dsq.eu. We copied the Arabic version directly from the website, with the author's written permission; we were not involved in its exact wording.

Setting

The study was conducted on a sample of respondents from Taif, Saudi Arabia.

Data analysis

Data were analysed using the R statistical software, version 3.4.1. Multiple generalised linear regression methods were used to estimate the effects of demographic factors on the scores and subscores of the 4DSQ. We included all demographic variables simultaneously in a full regression model with fixed effects:

$$\eqalign{\eta \lpar {4DSQ Score_i} \rpar & = \beta _0 + \beta _1 \times Marital\; Status_i + \beta _2 \times Age_i + \beta _3 \times Sex_i \cr & + \beta _4 \times Source\; of\; Info_i + \beta _5 \times Employment_i + \varepsilon _i} $$

where the index i (ranging from 1 to 347) represents the data pertaining to individual I; β0–β5 are estimates of the demographic effects; and η(.) is the linear predictor function for the Poisson distribution.

We considered each individual as an independent observation and used no random effects. We compared linear regression and Poisson regression models by examining the behaviour of the residuals in terms of normality and scatter when plotted against their corresponding fitted values. Poisson regression was superior in terms of model fit and diagnostics.

To compare the test results with the normative values, as shown in Table 2 below, we used the χ2-test to calculate P-values. We compared the counts observed in our sample with the normative population counts of the highest score class of factors, and related the association to the χ2 table with one degree of freedom.

We used the package ‘lavaan’ in R 3.4.1 to evaluate the latent factor structure of the 4DSQ subscales via confirmatory factor analyses.Reference Rosseel10 All the responses to the 50 4DSQ items were included as ordinal data in the model. To estimate factor loadings more accurately, we opted to use maximum likelihood with robust correction rather than diagonally weighted least squares.

Ethical approval

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. All procedures involving human subjects or patients were approved by the Research and Ethics Committee Western Region, affiliated to the Medical Services General Directorate. Registration number: H-02-T-078.

Consent

Written informed consent was obtained online from all participants.

Results

The study took place between April 2020 and May 2020 in a self-selected sample of the public from Taif, Saudi Arabia.

The total number of respondents included in the study was n = 347 Saudi subjects. Only one (0.29%) individual returned the questionnaire incomplete, and these missing responses were excluded from the analysis.

There were n = 213 (61.4%) males and n = 134 (38.6%) females. The mean age was 35.5 years (s.d. = 10.3 years). The age range was 12 to 63 years. The median age was 35 years (i.e. 50% of the sample were older than 35 years). Table 1 presents in detail the basic demographic factors of the participants. The ‘information source’ is the reported method used most often by the respondents to obtain information about COVID-19, whether word of mouth from friends and relatives, state-based media news channels, official resources released by the Ministry of Health, or social media outlets.

Table 1 Baseline demographics of the study participants

Among the respondents, n = 32 (9.2%) scored over 20 in terms of distress, indicating ‘strongly elevated’ distress. Moreover, n = 43 (12.4%) had strongly elevated depression scores, and n = 22 (6.3%) reported strongly elevated anxiety. In addition, n = 11 (3.2%) had strongly elevated somatisation scores. These results are shown in Table 2. All indices were significantly higher than the corresponding normative values for the 4SDQ scale reported by Terluin et al.Reference Terluin, Smits, Brouwers and de Vet11 This is indicative of increased anxiety, depression, somatisation and distress during the COVID-19 pandemic among the Saudi public.

Table 2 4DSQ results among participants

Reliability and internal consistency of the Arabic 4DSQ

The reliability coefficient for the distress subscale of the Arabic 4DSQ was 0.93 (95% CI: 0.92–0.94), indicative of excellent internal consistency. None of its items had a significant effect on the overall reliability estimate. Similarly, the reliability coefficient for the depression subscale was 0.88 (95% CI: 0.85–0.89), and that for the anxiety subscale was 0.89 (95% CI: 0.87–0.90), indicative of good internal consistency in both cases. All of the items had comparable effects on the overall reliability estimate. Moreover, the reliability coefficient for the somatisation subscale was 0.86 (95% CI: 0.84–0.88), again indicative of good internal consistency. All its items had comparable effects on the overall reliability estimate. Further information is available in Supplementary File 1 available at https://10.1192/bjo.2020.166.

Confirmatory factor analysis

We carried out a confirmatory factor analysis to ensure that the four dimensions were captured satisfactorily by the 4DSQ. However, the four-factor model did not fit in a satisfactory way for the full 50-item data-set. An overall five-factor structure was identified as the best compared with other models with lower numbers of factors. An additional dimension was required for the sample data to conform acceptably to the theoretical covariance structure. This was composed of item 1: ‘During the past week, did you suffer from dizziness or feeling light-headed?’, which was cross-loaded into the depression dimension; item 20: ‘During the past week, did you suffer from disturbed sleep?’, which was cross-loaded into the somatisation, depression and distress dimensions; and item 46: ‘During the past week, did you ever think I wish I was dead?’ which loaded on the additional fifth dimension only. See Supplementary File 3 for a detailed account of the five-factor loading.

We attempted to perform confirmatory factor analysis of a four-factor model after the removal of the three items above. The model was better than the four-factor model in the full data-set and of comparable acceptable fit to the five-factor model; see Table 3.

Table 3 Comparison of four models for the 4DSQ factor structure

CFI, comparative fit index; TLI, Tucker–Lewis index; RMSEA, root mean square error of approximation; SRMR, standardised root mean square residual.

For a good fit, it is preferred that the comparative fit index and Tucker–Lewis index are greater than 0.95, and that the root mean square error of approximation (RMSEA) is less than 0.06.Reference Hu and Bentler12 An RMSEA value less than 0.05 indicates a good fit to the data-set, and RMSEA less than 0.08 indicates an acceptable fit.Reference Browne, Cudeck, Bollen and Long13

Effects of demographic factors on 4SDQ scores

Total 4DSQ scores

The total 4DSQ score was significantly increased in separated (incidence rate ratio [IRR] = 1.194 [95% CI: 1.013–1.396], P = 0.03), single (IRR = 1.08 [95% CI: 1.006–1.163], P = 0.034) and widowed (IRR = 1.416 [95% CI: 1.112–1.778], P = 0.004) individuals compared with those who were married. It was also increased by getting information from friends and relatives (IRR = 2.535 [95% CI: 2.281–2.811], P < 0.0001) and being unemployed (IRR = 1.127 [95% CI: 1.054–1.205], P < 0.0001). It was substantially reduced in participants who were older (each additional year of age decreased the IRR by 0.975 [95% CI: 0.972–0.978], P < 0.001), male (IRR = 0.705 [95% CI: 0.664–0.748], P < 0.0001), or university educated (IRR = 0.882 [95% CI: 0.828–0.941], P < 0.0001), and in those who used state media (IRR = 0.800 [95% CI: 0.743–0.861], P < 0.0001) or social media (IRR = 0.874 [95% CI: 0.816–0.935], P < 0.001) to get information related to COVID-19. See Table 4 , Figs. 1–5 and Supplementary File 2 for full details of the estimates of the effects of demographic variables on total and individual dimension 4DSQ scores.

Table 4 Estimates of the coefficients for effects of background factors on 4DSQ score and dimensions

Fig. 1 Effects of background factors on distress score.

Fig. 2 Effects of background factors on depression score.

Fig. 3 Effects of background factors on anxiety score.

Fig. 4 Effects of background factors on somatization score.

Fig. 5 Effects of background factors on total 4DSQ score.

Distress scores

The distress dimension score was significantly increased in separated (IRR = 1.459 [95% CI: 1.148–1.830], P = 0.001) and widowed individuals (IRR = 1.586 [95% CI: 1.101–2.213], P = 0.009) compared with those who were married. It was also increased by getting information from friends and relatives (IRR = 2.102 [95% CI: 1.772–2.483], P < 0.0001), but it was substantially reduced in participants who were older (each additional year of age decreased the IRR by 0.969 [95% CI: 0.965–0.975], P < 0.001), male (IRR = 0.701 [95% CI: 0.639–0.769], P < 0.001) or university educated (IRR = 0.838 [95% CI: 0.759–0.925], P < 0.0001), and in those who got information related to COVID-19 from state media (IRR = 0.750 [95% CI: 0.666–0.841], P < 0.001) or social media (IRR = 0.839 [95% CI: 0.756–0.931], P < 0.001).

Neither single marital status nor unemployment had a significant effect on the distress dimension score. See Table 4 and Supplementary File 2 for full details of the estimates of the effects of demographic variables on total and dimension 4DSQ scores.

Depression dimension score

The depression dimension score was significantly increased by getting information from friends and relatives (IRR = 3.209 [95% CI: 2.421–4.214], P < 0.001) and being unemployed (IRR = 1.409 [95% CI: 1.153–1.723], P = 0.001). It was substantially reduced in participants who were older (each additional year of age decreased IRR by 0.983 [95% CI: 0.974–0.993], P < 0.001), male (IRR = 0.546 [95% CI: 0.455–0.655], P < 0.0001) or university educated (IRR = 0.704 [95% CI: 0.589–0.843], P < 0.001), and in those who used state media (IRR = 0.480 [95% CI: 0.358–0.631], P < 0.001) to get information related to COVID-19.

Marital status and social media information did not affect depression dimension scores significantly. See Table 4 and Supplementary File 2 for full details of the estimates of the effects of demographic variables on total and dimension 4DSQ scores.

Anxiety dimension score

The anxiety dimension score was significantly increased by getting information from friends and relatives (IRR = 3.360 [95% CI: 2.664–4.215], P < 0.001) but substantially reduced in participants who were older (each additional year of age decreased IRR by 0.968 [95% CI: 0.960–0.976], P < 0.001), male (IRR = 0.837 [95% CI: 0.727–0.964], P = 0.013) or university educated (IRR = 0.794 [95% CI: 0.685–0.921], P = 0.002). Neither employment status nor use of state media or social media as a source of information significantly affected anxiety dimension scores. See Table 4 and Supplementary File 2 for full details of the estimates of the effects of demographic variables on total and dimension 4DSQ scores.

Somatisation dimension score

The somatisation dimension score was significantly increased by being single (IRR = 1.168 [95% CI: 1.021–1.336], P = 0.023), university educated (IRR = 1.154 [95% CI: 1.018–1.311], P = 0.026) or unemployed (IRR = 1.166 [95% CI: 1.031–1.321], P = 0.015) and by getting information from friends and relatives (IRR = 2.418 [95% CI: 1.958–2.967], P < 0.001). It was substantially reduced in older (each additional year of age decreased IRR by 0.983 [95% CI: 0.977 to 0.990], P < 0.001) and male (IRR = 0.704, P < 0.001) participants. Obtaining information from state or social media information did not significantly affect the somatisation dimension score. See Table 4 and Supplementary File 2 for full details of the estimates of the effects of demographic variables on total and dimension 4DSQ scores.

Discussion

Current times are extremely tough as the COVID-19 pandemic is flaring everywhere in the world. We provided some evidence through the results of our survey of increased levels of distress, depression, anxiety and somatisation symptoms among the Saudi public during the time of the COVID-19 pandemic. This provides grounds for genuine concern regarding the pandemic-associated psychosocial effects in Saudi Arabia. Our findings are consistent with the results of a recent systematic review of the psychological effects of the COVID-19 pandemic, which estimated a prevalence of 33% for depression and 28% for anxiety.Reference Luo, Guo, Yu and Wang14 A recent Italian study found increased levels of distress among the public, which, in turn, influenced the perceived negative effects of the COVID-19 crisis.Reference Cerami, Santi, Galandra, Dodich, Cappa and Vecchi15 Many factors have affected distress levels among the public during the current crisis. Lockdown measures and curfews have negative effects on people, particularly those unable to sustain themselves with such measures in place, leading to increased levels of anxiety and depression.Reference Rehman, Shahnawaz, Khan, Kharshiing, Khursheed and Gupta16 Worst, the evidence suggests that such high levels of distress, anxiety and poverty lead to a high risk of contracting COVID-19 and a higher risk of complications.Reference Batty, Deary, Luciano, Altschul, Kivimaki and Gale17 It has been theorised that COVID-19 infection activates the same immune–inflammatory pathways that are associated with a range of mental health difficulties.Reference Debnath, Berk and Maes18

One other factor that has been proposed to increase the psychological effects of COVID-19 is a lack of satisfaction with health information.Reference Cortés-Álvarez and Piñeiro-Lamas19 Although social media may spread enormous amounts of misleading and anxiety-provoking material about COVID-19, some countries have managed to use social media effectively to promote accurate public health advice and hence to limit feelings of depression and anxiety among the public.Reference Teufel, Schweda, Dörrie, Musche, Hetkamp and Weismüller20

One striking finding in our survey was the substantial negative effect of getting informal information from friends and relatives on all dimensions of psychological experiences. Word of mouth is quite influential in the cohesive tribal Saudi community, and many studies have found that it may form the main source of information about many medical and health-related issues.Reference Khan, Ahmed, Aldarmahi, Zaidi, Subahi and Shaikh21,Reference Alyami, Alswat, Omer, Ahmed, Alshammari and Alsaggaf22 Information about COVID-19 evolves by the hour, given its novel mechanisms. Hence, harmful rumours tend to spread widely via informal channels of information.Reference Tasnim, Hossain and Mazumder23

We identified females to be at increased risk of distress, depression and somatisation during the current COVID-19 crisis in Saudi Arabia. Many studies have confirmed that women are more susceptible to psychological distress during the current pandemic.Reference Stanton, To, Khalesi, Williams, Alley and Thwaite24 Females were also more likely to suffer depressive symptoms, particularly among healthcare workers. Biological factors could explain such differences in emotional susceptibility between men and women.

Our results confirm the high reliability for the scores of the four dimensions of the Arabic version of the 4DSQ scale. This corroborates good psychometric properties for the 4DSQ in primary care facilities.Reference Sitnikova, Dijkstra-Kersten, Mokkink, Terluin, van Marwijk and Leone25 Some authors went on to use the 4DSQ as a gold standard against which other psychometric tools could be compared.Reference Braam, van Oostrom, Terluin, Vasse, de Vet and Anema26 The Cronbach's alpha values for the four dimensions of the 4DSQ tool in its Arabic format indicated its high reliability and high internal consistency. Thus, the Arabic 4DSQ could be used reliably in various research and clinical settings to evaluate the presence and extent of symptoms of distress, depression, anxiety and somatisation among Arabic speakers.

We also demonstrated that for the Arabic 4DSQ to conform to the underlying four-factor structure, three items require removal. It is hard to explain why those three questions do not conform to the overall four-factor structure. One potential explanation is the repetition of their concepts in other items. For instance, item 20 ‘During the past week, did you suffer from disturbed sleep?’ and item 39 ‘During the past week, did you have difficulty in getting to sleep?’ seem to measure the same construct, although they belong to different dimensions. Moreover, death wishes are explored using both item 46 ‘During the past week, did you ever think I wish I was dead?’ and item 33 ‘During the past week, did you feel that you would be better off if you were dead?’. A clearer explanation could be found should the factor analysis be carried out in a large-scale face-to-face investigation. Of note, many studies have confirmed the factor structure in different languages, including Polish,Reference Czachowski, Terluin, Izdebski and Izdebski27 RussianReference Iakhno, Smulevich, Terluin, Reĭkhart, Zakharova and Andriushchenko28 and Turkish.Reference Terluin, Unalan, Turfaner Sipahioğlu, Arslan Özkul and van Marwijk29 However, as we examined the Arabic version of 4DSQ, we concluded that three items need revision before it can effectively measure the underlying four constructs in Arabic-speaking populations.

The current investigation, to the best of our knowledge, was the first validation of the Arabic version of the 4DQS. We presented the results of a study with many strengths. We used an established and well-validated tool. Our sample included a wide range of participants that could represent the Saudi public at large. We used robust statistical methods to model our data-set. However, several limitations must be acknowledged. Our survey was cross-sectional and observational and thus would allow for limited generalisability. The online survey was subject to technological availability and computer literacy. It was, however, the only reasonable option during the time of the COVID-19 pandemic. Furthermore, although the questionnaire was online and was theoretically accessible to all Saudi citizens, the recruitment invitation was sent out through social media outlets that were primarily used by local Taif-based people. It would be more accurate to assume that the obtained sample is representative of local Taif residents than of all Saudi Arabia. Moreover, the high education level observed in our survey was not representative of the wider Saudi population. It can be attributed to our respondents being those who had access to social media and were more willing to complete the online survey. Similarly, the nature of the online survey may have left out older and retired respondents. The low participation by females could well be related to unique Saudi cultural, social and religious restrictions. However, substantial changes are underway in Saudi Arabia; hence, future surveys should suffer less from this gender difference in participation. Moreover, we did not use a completely matched control from Saudi Arabia for our normative data. The normative data we used were different in terms of geographical localisation, method of interview and recruitment practicality.

We need to be cautious before directly attributing detrimental effects on mental health to the COVID-19 pandemic or the curfew. We must consider the effects of limited access to mental health services during the pandemic.

Future research should include a large number of respondents (preferably thousands) and, as the pandemic eases, should use face-to-face measures. We did not collect data pertaining to the effects of ethnicity on 4DSQ scores. Future research should consider that in more depth.

Psychological sequelae to the COVID-19 pandemic are quite prevalent and should be addressed by public health measures hand in hand with medical sequelae. Furthermore, the provision of accurate information about COVID-19 by the state media and Ministry of Health is an important factor in alleviating psychological distress during the COVID-19 crisis. The Arabic version of the 4DSQ is reliable and valid; however, it requires reconsideration of three repetitive items before it can safely be used in primary and specialist care settings in Saudi Arabia and the Arabic-speaking world.

Based on our results, public health campaigns should clearly advise the public to avoid word-of-mouth information regarding the COVID-19 pandemic and coronavirus. The public should prefer institutional and official communications provided through the Ministry of Health, governmental sites and media outlets.

Supplementary material

Supplementary material is available online at https://doi.org/10.1192/bjo.2020.166.

Data availability

The data that support the findings of this study are available from the corresponding author, M.O., upon reasonable request.

Acknowledgements

We thank the participants for generously volunteering their time and effort to complete the survey. We also thank the anonymous peer reviewers whose constructive comments improved the quality of our work tremendously.

Author contributions

All authors contributed effectively to the design, conception, data management, and data analysis and interpretation. All approved the final version of the manuscript.

Funding

None.

Declaration of interest

None.

Footnotes

*

Joint first authors.

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Figure 0

Table 1 Baseline demographics of the study participants

Figure 1

Table 2 4DSQ results among participants

Figure 2

Table 3 Comparison of four models for the 4DSQ factor structure

Figure 3

Table 4 Estimates of the coefficients for effects of background factors on 4DSQ score and dimensions

Figure 4

Fig. 1 Effects of background factors on distress score.

Figure 5

Fig. 2 Effects of background factors on depression score.

Figure 6

Fig. 3 Effects of background factors on anxiety score.

Figure 7

Fig. 4 Effects of background factors on somatization score.

Figure 8

Fig. 5 Effects of background factors on total 4DSQ score.

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