Major depressive disorder (MDD) is a common mental illness: combined study data from 30 countries show 1-year and lifetime prevalence rates of 7.2% and 10.8% respectively.Reference Lim, Tam, Lu, Ho, Zhang and Ho1 Moreover, it has a continuous high risk of recurrence, which represents an increased disease burden.Reference Collins, Patel, Joestl, March, Insel and Daar2 Findings from the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) study suggest that 30% of people with MDD do not enter remission, despite receiving fourth-line treatment.Reference Gaynes, Rush, Trivedi, Wisniewski, Spencer and Fava3 Additionally, 50% of people with MDD relapse after their first episode, 70% after the second and 90% after their third.Reference Angst, Gamma, Rossler, Ajdacic and Klein4 This illustrates the real danger of chronic depression after the initial MDD diagnosis.
Effects of MDD on families
For many families, an MDD diagnosis means long and difficult periods marked by high stress. It can involve a great deal of familial suffering, including a higher divorce rateReference Kessler, Walters and Forthofer5 and severe financial strain.Reference Judd, Paulus, Wells and Rapaport6 Balkaran et al's studyReference Balkaran, Jaffe, Umuhire, Rive and Milz7 of five Western European countries reported that caregivers of adults with unipolar depression have a greater burden than caregivers of adults with other chronic mental or physical diseases (e.g. Alzheimer's disease, bipolar disorder, schizophrenia, cancer or chronic kidney disease). In terms of their health status (measured using the Short Form-6 Dimensions) and health-related quality of life (measured using the Medical Outcomes Study 12-item Short-Form survey instrument, version 2), the unipolar depression caregiver group had significantly worse scores than the other chronic disease caregiver groups. Families of patients with MDD find some patient behaviours difficult to understand, and they experience negative consequences such as grief, withdrawal and worrying, which cause further problems; however, few families know how to manage patients’ difficult behaviour.Reference Fadden, Bebbington and Kuipers8 Marguerite et alReference Marguerite, Laurent, Marine, Tanguy, Karine and Pascal9 reported that caregivers’ coping strategies, such as problem-solving, positive thinking and avoidance, affect both their own and patients’ mental health. Caregivers’ use of positive thinking and problem-solving was associated with a decrease in their own level of anxiety. Conversely, using avoidance strategies increased caregivers’ own depression and anxiety, as well as patients’ anxiety. These results suggest that it is important for both patients and caregivers to have the appropriate information on how to treat depression and to implement appropriate coping strategies for daily problems in order to recover from depression and to maintain the caregiver's own mental health.
Expressed emotion
A family's expressed emotion (EE) is a good predictor of schizophrenia relapse.Reference Butzlaff and Hooley10,Reference Amaresha and Venkatasubramanian11 EE is an index representing the familial relationship and is assessed by examining the content of emotions expressed towards the patient by family members. Concerning MDD, although Hayhurst et alReference Hayhurst, Cooper, Paykel, Vearnals and Ramana12 reported that there is no clear association between the EE of a spouse and recurrence of depression in the patient, three studies reported that high EE predicts negative consequences.Reference Hooley, Orley and Teasdale13–Reference Uehara, Yokoyama, Goto and Ihda15 A study involving 39 people with MDD reported that 59% of those living with high-EE spouses relapsed, whereas none living with low-EE spouses did so.Reference Hooley, Orley and Teasdale13 Among 40 individuals with MDD, another study's logistic model indicated that two strong factors predicted the 6-month outcome of depressive episodes: the level of criticism in the family's EE and their history of major depression.Reference Uehara, Yokoyama, Goto and Ihda15 In a study on the interaction between individuals with MDD and the level of their spouses' EE, compared with low-EE spouses, spouses rated as high EE expressed more negative (and fewer positive) feelings towards partners with MDD, both verbally and non-verbally. High-EE spouses also made more critical comments and disagreed with partners more frequently. Moreover, high levels of EE in spouses were associated with low frequencies of self-disclosure in patients.Reference Hooley16 These studies suggest the need for a more family-oriented approach in MDD treatment. UK clinical guidelines from the National Institute for Health and Care Excellence (NICE) recommend a couples-focused intervention as one of the evidence-based treatments for depression.17 However, Henken et al's review reported that despite the lack of high-quality evidence in this field, family therapy is already a widely used intervention for treating depression.Reference Henken, Huibers, Churchill, Restifo and Roelofs18
Family psychoeducation
Family psychoeducation (FPE) is recognised as an important part of optimal treatment, along with traditional medication and counselling, for people with a psychotic disorder.Reference Dixon, Adams and Lucksted19,Reference Pitschel-Walz, Leucht, Bauml, Kissling and Engel20 This intervention is recommended for schizophrenia treatment by the US Department of Health and Human Services’ Substance Abuse and Mental Health Services Administration (SAMHSA)21 and by NICE.22 As treatment for bipolar disorder, FPE – called family-focused therapy – has been shown to be effective as an adjunctive treatment.Reference Miklowitz23,Reference Miklowitz and Chung24 FPE is the method of working with families who want to support persons with mental illness. FPE is more than merely information provision; it ensures that people understand the illness. Importantly, it focuses on the development of problem-solving, communication and coping skills and the enhancement of social support to manage mental illness. In family therapy, the family itself is the object of treatment, whereas in the FPE approach, the illness is the object of treatment, not the family.21 This intervention has been shown to reduce the relapse rate and hospital admissions among individuals with psychotic disorders and to reduce caregiver burden.Reference Miklowitz23–Reference Bulut, Arslantas and Ferhan Dereboy26
However, FPE is still not widely available for people with MDD and their families. Several studies report on the effectiveness of FPE for MDD. Shimazu et alReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27 examined the effect of FPE in treating 25 individuals diagnosed with MDD, compared with a control group (n = 32). The FPE consisted of four sessions for caregivers without the participation of patients. The findings showed that FPE was effective in preventing relapse at 9 months in adults with MDD. Fiorillo et alReference Fiorillo, Malangone and Del Vecchio28 and Luciano et alReference Luciano, Del Vecchio, Giacco, De Rosa, Malangone and Fiorillo29 reported similar findings from their study. Their intervention package consisted of 12 single-family sessions. The authors reported that the FPE intervention helped reduce personal and family difficulties caused by depression and improved social contact. However, the follow-up period in this study was short (6 months), with no clarity on long-term effects. Clarkin et alReference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30 and Glick et alReference Glick, Clarkin, Spencer, Haas, Lewis and Peyser31,Reference Glick, Clarkin, Haas and Spencer32 compared a psychoeducational in-patient family intervention with standard hospital treatment of depression symptoms. Female participants in the experimental group reported a reduction in depression symptoms. This study revealed gender to be a mediating variable.
There is, to date, no meta-analysis examining the effectiveness of FPE for MDD, and only one related narrative review could be traced.Reference Brady, Kangas and McGill33 Our clinical question therefore asks whether FPE reduces the severity of symptoms in people with MDD, compared with a control group. This systematic review and meta-analysis aims to evaluate the evidence on the effectiveness of FPE on the severity of depressive symptoms in people with MDD.
Method
A review protocol was developed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelinesReference Liberati, Altman, Tetzlaff, Mulrow, Gøtzsche and Ioannidis34 and was registered with PROSPERO (reference: CRD42020185884).Reference Booth, Clarke, Dooley, Ghersi, Moher and Petticrew35 We searched the PubMed, MEDLINE, Embase, PsycInfo, the Cochrane Library, Emcare, ProQuest Dissertation and Theses, and the Web of Science databases to identify eligible studies of FPE for MDD, from their inception up to March 2022. The search included all relevant terms, such as ‘family education’, ‘family psychoeducation’, ‘family’, ‘family therapy’, ‘family relations’, ‘family health’, ‘health education’, ‘patient education as topic’, ‘psychoeducat*’, ‘psycho educat*’, ‘family therap*’ and ‘family intervention’, in combination with ‘depressive disorder’, ‘depressive disorder*’ and ‘depression’ (supplementary Table 1, available at https://doi.org/10.1192/bjo.2022.543). Abstracts identified during the literature search were screened by two pairs of review authors (F.K. and A.Y., F.K. and T.H.) independently. Potentially eligible articles were read by the two pairs of review authors (F.K. and A.Y., F.K. and T.H.) to determine whether they met the eligibility criteria. Disagreements were discussed with a third review author (N.W.) until consensus was reached. As necessary, additional information was obtained from the study authors.
Eligibility criteria
Study types
All published and unpublished randomised controlled trials (RCTs) were included. We excluded quasi-randomised studies, such as those that allocated participants according to alternate days of the week. When identified, we included cluster trials. We also included cross-over trials that were identified, but only used data up to the first cross-over because of the instability of outcomes and the likelihood of carry-over effects of all treatments.
Participants
The study populations included patients with a primary diagnosis of MDD, based on DSM or ICD criteria, and their family members. There were no restrictions on participants’ gender, ethnicity or comorbidities. Patients with MDD who had no current symptoms and those in both hospital and community settings were included. The following studies were excluded: those with patients whose main diagnosis was schizophrenia, bipolar disorders, Alzheimer's disease, anorexia nervosa, bulimia nervosa, psychotic episodes or epilepsy; those with patients with MDD secondary to physical illness; studies in which patients who were less than 18 years old accounted for more than 50% of the sample; and studies in which the only family members attending the FPE were children younger than 18 years.
Intervention
FPE is a method for working with families who are supporting persons with mental illness. FPE comprises several established methods, such as family management,Reference Falloon36 behavioural family therapyReference Mueser, Glynn and Liberman37 and multiple-family therapy.Reference McFarlane38 These interventions often overlap with each other. The common elements in these interventions are as follows: providing education on the nature of mental illness; giving practical advice on coping strategies; encouraging families to sustain their own life trajectories; teaching effective communication skills; enhancing communication and assisting family members in using modes of problem-solving and stress management.Reference Liberman and Liberman39 Considering these elements, we defined FPE as follows: FPE is more than just providing information; it ensures that affected people understand the illness. It also focuses on the development of problem-solving, communication skills, coping skills and social support enhancement to manage depression. We included individual and group programmes that involve interaction between the information provider and participants. Any delivery model was included, such as face-to-face, online virtual forums (such as phone, chat or Skype) and a mix of different delivery models. We excluded brief interventions that focus only on didactic education or health information using textual or video materials in any delivery model. There were no restrictions on programme duration or on the number of sessions. The programmes were led by medical professionals, but there was no limit on the training time of the facilitators delivering the psychoeducational intervention. Mutual support groups that were facilitated solely by family members from the outset were excluded.
Comparators
Family members in the control group did not receive FPE. They might have received other support (such as counselling or self-help support groups) but were excluded if they received support with treatment components of psychoeducation. Control groups on a waiting list and with active placebo were included. Studies with structured psychotherapy for only intervention group patients were excluded.
Outcomes
The primary outcomes of this study were patients’ depressive symptoms, depression above the threshold and family functioning. Assessment times were divided at 16 weeks (defined from 12 weeks to 20 weeks) and a final follow-up. We defined each primary outcome as follows.
(a) Patients’ depressive symptoms were measured on the following standard scales: masked (blind)-assessed Hamilton Rating Scale for Depression (HRSD),Reference Hamilton40 which was preferentially adopted; masked-assessed Montgomery–Åsberg Depression Rating Scale (MADRS);Reference Montgomery and Åsberg41 the self-reported Beck Depression Inventory (BDI);Reference Beck, Steer and Brown42 and the self-reported Patient Health Questionnaire (PHQ-9).Reference Spitzer, Kroenke and Williams43
(b) For ‘depression above the threshold’, a cut-off value of remission was defined as an HRSD score of 7 or lower,Reference Riedel, Möller, Obermeier, Schennach-Wolff, Bauer and Adli44 MADRS score of 9 or lower,Reference Hawley, Gale and Sivakumaran45 BDI score of 13 or lowerReference Hiroe, Kojima, Yamamoto, Nojima, Kinoshita and Hashimoto46 and PHQ-9 score of 9 or lower.Reference Kroenke, Spitzer and Williams47
(c) Family functioning was measured using standardised, validated and reliable measures such as: the Family Assessment Device (FAD),Reference Epstein, Baldwin and Bishop48 which was preferentially adopted; (2) the Five-Minute Speech Sample (FMSS), to measure EE;Reference Magaña-Amato49 the Family Attitude Scale (FAS), to measure EE;Reference Kavanagh, O'Halloran, Manicavasagar, Clark, Piatkowska and Tennant50 the Family Cohesion and Adaptability Evaluation Scale (FACES);Reference Olson, Portner and Bell51 and the Family Environment Scale (FES).Reference Moos and Moos52
We defined each secondary outcome as follows.
(a) Patients’ general functioning was assessed using standard measures of general functioning such as: the Global Assessment of Functioning (GAF) scale,53 which was preferentially adopted; and the Mental Component Summary (MCS) of the Medical Outcomes Study's (MOS) 36-item Short-Form Health Survey (SF-36).Reference Ware and Sherbourne54
(b) Family members’ distress was measured using standardised, validated and reliable measures such as: the BDI,Reference Beck, Steer and Brown42 which was preferentially adopted; the Symptom Checklist (SCL);Reference Derogatis, Lipman and Covi55 and the Kessler Psychological Distress Scale (K6).Reference Kessler, Barker, Colpe, Epstein, Gfroerer and Hiripi56
(c) Family members’ quality of life was measured on standardised, validated and reliable measures, such as: the World Health Organization's Well-Being Index (WHO-5),Reference Topp, Østergaard, Søndergaard and Bech57 which was preferentially adopted; and the MCS of the MOS SF-36.Reference Ware and Sherbourne54
(d) Drop-out rate from intervention and assessment.
Data extraction and quality evaluation
The following data were extracted from each study: (a) the first author's name, publication year and the country in which the study was carried out; (b) depression inclusion criteria; (c) sample characteristics; (d) intervention characteristics; number of patients with MDD at baseline; (e) outcome measures; (f) follow-up duration; and (g) number dropping out of assessment. For missing data, attempts were made to contact the principal investigators of the included studies to obtain unreported data or additional details, where possible. Two independent reviewers (F.K. and A.Y.) first separately, and then together, assessed the risk of bias. For RCTs included in the search, the risk of bias was assessed according to the Cochrane risk of bias assessment tool.Reference Higgins and Green58 The following processes were used to assess bias risk: random sequence generation; allocation concealment; participant masking; masking of outcome assessment; incomplete outcome data; selective reporting; and other sources of bias. Disagreements between the review authors over the risk of bias in individual studies were resolved by discussion, with the involvement of a third review author (N.W.) where necessary. Moreover, we used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the quality of the body of evidence.Reference Guyatt, Oxman, Vist, Kunz, Falck-Ytter and Alonso-Coello59 The GRADE method involves rating the initial quality of evidence for an association as high, followed by downgrading based on five criteria (risk of bias, inconsistency, indirectness, imprecision and publication bias).
Statistical analysis
We conducted a meta-analysis using Review Manager 5.4 software for Windows and a random effects model, if at least two studies assessing this specific outcome were obtainable. For continuous outcomes, standard mean differences (s.m.d.) with 95% confidence intervals (95% CI) were calculated as the difference in means between groups divided by the pooled standard deviation (s.d.). For dichotomous data, the risk ratio and 95% CIs were calculated. We calculated dichotomous data from the continuous data using the mean, s.d. and number of participants, according to the statistical methods recommended by Cochrane.Reference Li, Higgins, Deeks, Higgins, Thomas, Chandler, Cumpston, Li, Page and Welch60 We calculated the number of participants above and below the cut-off value of each depression scale. A cut-off value for remission was defined as an HRSD score of 7 or lower,Reference Riedel, Möller, Obermeier, Schennach-Wolff, Bauer and Adli44 BDI score of 13 or lowerReference Hiroe, Kojima, Yamamoto, Nojima, Kinoshita and Hashimoto46 and PHQ-9 score of 9 or lower.Reference Kroenke, Spitzer and Williams47 If the studies had more than one intervention group, the number of participants in the control group was divided by the number of intervention groups to avoid double-counting of participants in control groups.Reference Higgins, Li, Deeks, Higgins, Thomas, Chandler, Cumpston, Li, Page and Welch61 For studies that did not report data with s.d., we calculated these values from standard errors or 95% CIs. For pooled analyses, we quantified statistical heterogeneity using the I 2 statistic, which describes the percentage of total variation across trials due to heterogeneity rather than sampling error. If sufficient data were available, subgroup analyses were conducted for type of provider system, type of delivery system, severity of depressive symptoms at baseline, comorbidity of depression, support condition of family members in the control group and relationship with family members. As necessary, we performed sensitivity analyses by removing studies one at a time, to evaluate the stability of the result. If at least ten studies were included in a meta-analysis, we assessed publication bias by visual analysis of funnel plots.
Results
Identified studies for the meta-analysis
The literature search retrieved 2717 records. After duplicates were removed, we initially identified a total of 1823 records, and 1756 were excluded after reviewing the titles and abstracts. We obtained 67 relevant articles for full-text review, and a further 50 studies were excluded for the following reasons: 2 were not RCTs, 32 did not include eligible patients, 11 did not include eligible interventions, and 5 were ongoing and did not provide any actual data.Reference Frank, Wilk, Kriston, Meister, Shimodera and Hesse62–Reference Fujita66 Thus, out of 17 remaining records, 9 studiesReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Fiorillo, Malangone and Del Vecchio28,Reference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32,Reference Prisco, Del Vecchio, Luciano, Giacco, Sampogna and Del Gaudio67–Reference Hinton78 met the inclusion criteria for qualitative synthesis and 5 studiesReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Hinton78 met the inclusion criteria for the meta-analysis (supplementary Fig. 1)
Study characteristics and quality evaluation included in the meta-analysis
This meta-analysis included 5 studiesReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Hinton78 totalling 301 patients with MDD and a family member: 175 in the intervention groups and 126 in the control groups. One study consisted of three separate intervention arms and a shared control group.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72 Participant details and intervention characteristics are shown in Table 1. Participants met the criteria for MDD according to DSM-IVReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Seikkula, Aaltonen, Kalla, Saarinen and Tolvanen73,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 or ICD-10Reference Kumar and Gupta74 and one study defined MDD with a PHQ-9 score of 15 or higher.Reference Hinton78 Most interventions included providing information on MDD and confirming how participants understood the condition.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Hinton78 Two studies used problem-solving,Reference Kumar and Gupta74–Reference Katsuki77 three studies promoted communication among family members,Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Seikkula, Aaltonen, Kalla, Saarinen and Tolvanen73,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 four studies enhanced strengths and family coping skillsReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Kumar and Gupta74–Reference Hinton78 and multifamily intervention in two studies enhanced social support.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 Four studies described an FPE intervention that included patients.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Kumar and Gupta74,Reference Hinton78 The control condition for family members was that they had not received any treatment. Typical patient treatments in both intervention and control groups included medication,Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Hinton78 supportive psychotherapyReference Kumar and Gupta74–Reference Katsuki77 or individual or group psychotherapyReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Seikkula, Aaltonen, Kalla, Saarinen and Tolvanen73 (Table 1). The quality of the included studies varied (supplementary Fig. 2). Two of five studies reported an adequate sequence generation.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 Two studies reported allocation to conditions by an independent party.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 Two studies reported incomplete outcome dataReference Kumar and Gupta74–Reference Katsuki77 and two studies published protocols and analysed results according to those protocols.Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Hinton78 All the RCTs had an unclear or high risk of bias regarding participant masking because of the nature of these studies. Following the GRADE methodology, we graded the quality of evidence for the outcomes of each meta-analysis. All outcomes were graded with a very low degree of certainty (supplementary Table 2). As fewer than ten studies were included in each meta-analysis, funnel plots were not analysed.
Table 1 Characteristics of the participants and interventionsa
CBT, cognitive–behavioural therapy.
a. For each study, the upper row of data (the upper two rows for study 1) relates to the intervention group and the lower row to the control group.
b. #1: providing information on the illness (major depressive disorder) and ensuring that people have an understanding of the illness. #2: using problem-solving. #3: enhancement of communication among family members. #4: enhancement of strength and coping. #5: enhancement of social supports. #6: including the patient.
c. Beck Depression Inventory-II.
d. Hamilton Rating Scale for Depression.
e. Patient Health Questionnaire-9.
f. Patient alone and/or with family members.
Effects on patients’ depressive symptoms
The effect of FPE on patients’ depressive symptom severity as primary outcomes, compared with the control condition, at 16 weeks (from 12 weeks to 20 weeks) was available for five comparisons of four RCTs,Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Kumar and Gupta74–Reference Hinton78 and final follow-up data were available for six comparisons of five RCTs.Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Hinton78 The meta-analysis of combined data showed a significant improvement in patients’ depressive symptoms at 16 weeks (s.m.d. = −0.52; 95% CI 1.03 to −0.01) and at a final follow-up (s.m.d. = −0.53; 95% CI −0.98 to −0.08). Fig. 1 illustrates forest plots of the standard mean differences and their confidence intervals. Heterogeneity was substantial at 16 weeks (I 2 = 61%) and at a final follow-up (I 2 = 60%). Although two studies used clinician-rated instruments (HRSD)Reference Seikkula, Aaltonen, Kalla, Saarinen and Tolvanen73,Reference Kumar and Gupta74 for depressive symptom assessment, three used self-report instruments (BDI, PHQ-9)Reference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Hinton78 (Table 1). The final follow-up period ranged from 3 to 24 months (Table 1). Fig. 2 shows the results of a meta-analysis for depression above the threshold in the same population. The meta-analysis of the depression rate above threshold using the pooled relative risks showed a non-significant improvement rate at 16 weeks (risk ratio 0.82; 95% CI 0.64–1.05) and a significant improvement rate at final follow-up (risk ratio 0.75; 95% CI 0.64–0.89). Heterogeneity was moderate at 16 weeks (I 2 = 43%) and low at final follow-up (I 2 = 0%).
Fig. 1 Forest plots for severity of patients’ depressive symptoms. IV, inverse variance; FPE, family psychoeducation.
Fig. 2 Forest plots for depression above the threshold. M–H, Mantel–Haenszel; FPE, family psychoeducation.
Family functioning
The meta-analysis on the effect of FPE on family functioning as one of the primary outcomes, using the FAS, showed a non-significant improvement at both 16 weeks (m.d. = 4.15; 95% CI −11.66 to 19.96) and final follow-up (m.d. = 7.50; 95% CI −7.62 to 22.62; supplementary Fig. 3). Only one studyReference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 reported family functioning and family members’ distress.
Other comparisons
Data on The effect of FPE on patients’ general functioning, compared with the control condition, at 16 weeks were available in two RCTsReference Kumar and Gupta74–Reference Katsuki77 and at a final follow-up in three RCTs.Reference Seikkula, Aaltonen, Kalla, Saarinen and Tolvanen73–Reference Katsuki77 The meta-analysis of the combined data showed a non-significant improvement in patients’ general functioning using the MSC of SF-36 or the GAF at 16 weeks (s.m.d. = 0.64; 95% CI −0.15 to 1.44) and at a final follow-up (s.m.d. = 0.39; 95% CI −0.28 to 1.06; supplementary Fig. 4). There was no significant effect of FPE on family members’ distress using the BDI at 16 weeks (m.d. = −1.85; 95% CI −7.12 to 3.42) or at a final follow-up (m.d. = 0.95; 95% CI −4.60 to 6.50; supplementary Fig. 5). We calculated the risk ratio of the drop-out rate from intervention and assessment (supplementary Fig. 6). In terms of the drop-out rate from intervention, fourReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72,Reference Kumar and Gupta74–Reference Hinton78 of five studies had no one dropping out from the intervention or control group. Considering the drop-out rate from assessment, oneReference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 out of five studies had no one dropping out from the intervention or control group. These studies were excluded from the meta-analysis. There was no significant difference in the drop-out rate between the intervention and control groups (risk ratio 0.59; 95% CI 0.24–1.47), but a significant difference was observed in the drop-out rate from assessment (risk ratio 0.50; 95% CI 0.31–0.80).
Subgroup and sensitivity analysis
The small number of studies in the meta-analysis did not allow for subgroup analysis. Sensitivity analysis was not performed because there were no outlier data.
Studies excluded from the meta-analysis
Four studiesReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Fiorillo, Malangone and Del Vecchio28,Reference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32,Reference Prisco, Del Vecchio, Luciano, Giacco, Sampogna and Del Gaudio67–Reference Hu, Wang and Fu71 of ten records had no data available for our meta-analysis. Three studiesReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Fiorillo, Malangone and Del Vecchio28,Reference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32,Reference Prisco, Del Vecchio, Luciano, Giacco, Sampogna and Del Gaudio67–Reference Shimodera70 did not include adequate means and standard deviations. One studyReference Hu, Wang and Fu71 did not provide detailed contents of the FPE intervention. We requested the detailed data from the respective authors but could not retrieve them, as they were already discarded or the authors could not be reached. Therefore, these studies could not be included in the meta-analysis. These studies’ participants met the criteria for MDD according to DSM-III,Reference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32 DSM-IVReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Fiorillo, Malangone and Del Vecchio28,Reference Shimodera, Furukawa, Mino, Shimazu, Nishida and Inoue68–Reference Shimodera70 or the Chinese Classification of Mental Disorders Version 3.Reference Hu, Wang and Fu71 Interventions for family members are shown in Table 1. The Clarkin studyReference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32 reported no significant improvement (F = 3.12, P = 0.09 at 18 months) in the patients' general functioning, measured on the Global Assessment Scale. Hu Xiong et alReference Hu, Wang and Fu71 reported significant improvement (P < 0.01 at 24 months) in patients’ depressive symptoms, measured on the HRSD. Fiorillo et al's studyReference Fiorillo, Malangone and Del Vecchio28,Reference Prisco, Del Vecchio, Luciano, Giacco, Sampogna and Del Gaudio67 reported a significant reduction in patients’ symptom severity (P < 0.05) and family burden (P < 0.05) compared with the control group. Shimazu et alReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Shimodera, Furukawa, Mino, Shimazu, Nishida and Inoue68–Reference Shimodera70 reported that patients who had achieved full or partial remission from an acute depressive episode had a significantly lower relapse rate during a 9-month follow-up period compared with those in the control group (risk ratio 0.17; 95% CI 0.04–0.66; number needed to treat 2.4; 95% CI 1.6–4.9).
Discussion
To the best of our knowledge, this is the first meta-analytical study exploring the effectiveness of FPE for MDD. We found that FPE had a small but statistically significant effect on the depressive symptoms of people with MDD, in both the short and long term. This suggests that FPE as a psychosocial intervention may be expected to improve the depressive symptoms of people with MDD. Major depression has many effects on family functioning.Reference Keitner and Miller79 Individuals with a neurobiological vulnerability to major mental disorders are highly sensitive to stressors. Coping with stressors can be impeded by ineffective efforts at communication and problem-solving among family members. Expressing ideas and feelings, making requests of each other and dividing big problems into small steps are skills that few families have mastered.Reference Liberman and Liberman39 In a survey of mental health workers who support people with depression and their caregivers, 80% of participants answered yes to the question of whether the family members of a person with depression could prevent recurrence by gaining appropriate knowledge about the condition.Reference Wirrell, McGill, Kelly and Bowman80 However, only 23% of participants answered yes to the question regarding whether the caregivers were learning to manage depression appropriately. The FPE intervention may help families obtain knowledge about MDD, develop coping strategies for problems in daily life and improve communication between family members and patients. Appropriate coping strategies among family members, such as problem-solving and positive thinking, may reduce the stress for both the patients and family members.Reference Marguerite, Laurent, Marine, Tanguy, Karine and Pascal9 This may also reduce caregivers' EE and have a positive effect on the patients’ prognosis.Reference Hooley, Orley and Teasdale13–Reference Uehara, Yokoyama, Goto and Ihda15 This is believed to result in reduced stress for both family members and patients and reduced depressive symptoms among patients. However, although the EE-lowering effect of FPE has been confirmed for schizophrenia,Reference Amaresha and Venkatasubramanian11 it has not yet been confirmed for MDD. In addition, there was no significant improvement in family functioning and family members’ distress in the present study. Thus far, only a few studies have examined the effects of family functioning and family members’ distress on people with MDD. Additionally, the studies included in the present study differed from each other in terms of intervention contents and the usual treatment type for patients in the intervention and control groups (Table 1); the quality of most studies in this field was suboptimal. Furthermore, four studiesReference Lemmens, Eisler, Buysse, Heene and Demyttenaere72–Reference Kumar and Gupta74,Reference Hinton78 used an FPE intervention including patients whereas one study Reference Katsuki, Takeuchi, Inagaki, Maeda, Kubota and Shiraishi75–Reference Katsuki77 was with a family member only. Because of the small number of studies, it was not possible to analyse each intervention and its control conditions separately using subgroup analyses. Therefore, these results should be considered with caution and verified through further research.
Although there are several meta-analysesReference Donker, Griffiths, Cuijpers and Christensen81,Reference Moreno-Lacalle82 on the effect of psychoeducation on people with MDD, to date, there has been no meta-analysis on FPE for MDD. However, there are two narrative reviews on family therapy for MDD, of which one involved FPEReference Brady, Kangas and McGill33 and one comprised both family therapy and FPE.Reference Henken, Huibers, Churchill, Restifo and Roelofs18 The single systematic reviewReference Brady, Kangas and McGill33 of FPE for MDD included six RCTs and three single-arm trials. This review stated that the results provide preliminary evidence that FPE leads to improved outcomes for patients’ functioning and family caregivers’ well-being when caring for people with depression. Another reviewReference Henken, Huibers, Churchill, Restifo and Roelofs18 involved six RCTs and addressed not only FPE, but also other types of family therapy. This review revealed that despite the lack of high-quality evidence in the field, family therapy is already a widely used intervention for depression. Our findings, however, are the first to show quantitative results. Additionally, four studiesReference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Fiorillo, Malangone and Del Vecchio28,Reference Clarkin, Glick, Haas, Spencer, Lewis and Peyser30–Reference Glick, Clarkin, Haas and Spencer32,Reference Prisco, Del Vecchio, Luciano, Giacco, Sampogna and Del Gaudio67–Reference Hu, Wang and Fu71 identified during the present study that were not included in the meta-analysis report a significant effect of FPE on patients’ depressive symptoms or general functioning. In particular, Shimazu et al reported high prevention of recurrence of MDD when applying FPE.Reference Shimazu, Shimodera, Mino, Nishida, Kamimura and Sawada27,Reference Shimodera, Furukawa, Mino, Shimazu, Nishida and Inoue68–Reference Shimodera70 Moreover, the FPE intervention in that study targeted family members only. Overall, family care is important for MDD treatment, and FPE can be expected to be effective in those recovering from MDD.
Limitations of the study
This meta-analysis had several limitations. First, the sample size across the included studies was relatively small. A meta-analysis on such a small sample limits any inference of a pooled effect. Second, only five RCTs were included in the meta-analysis and all of the included studies were of low quality (supplementary Fig. 2). In several studies it was unclear whether the authors concealed random allocation. Almost all the studies did not mask the participants and outcome assessors. Third, according to the GRADE framework, the certainty of each outcome was very low (supplementary Table 2). The total number of participants in this meta-analysis was small and the I 2 value measuring inconsistency indicated substantial heterogeneity. Some outcomes showed low risk of indirectness, as each study had a different follow-up period. Fourth, several questionnaires that measured depressive symptoms included self-report questionnaires. Fifth, in the meta-analysis of the depression rate above threshold, when we converted continuous data to dichotomous data, we did not examine whether the normal distribution held true. Last, in the studies included in the present study, participants with MDD received additional treatments in both the intervention and control groups. Considering these limitations, the results regarding the effectiveness of FPE for MDD may change in future studies. However, the strengths of this study were that all the steps were performed by two or more independent researchers and a wide range of literature databases were included, such as ProQuest Dissertations and Theses.
Implications
As one of the psychosocial interventions, FPE can be expected to improve depressive symptoms in people with MDD. These results, however, should be confirmed in further randomised trials because of the clinical heterogeneity and the low quality of the included studies and because the clinician-rated outcomes were not significant. Higher-quality RCTs that include large samples and masking of assessors are needed. Researchers must publish study protocols prior to research and subsequently analyse data according to the respective protocols. The effectiveness of FPE for MDD is yet to be validated and it is not yet highly recommended. The results of the present study suggest that FPE for MDD can be expected to promote symptom-improving effects and have a recurrence-prevention effect when combined with other treatments.
Supplementary material
Supplementary material is available online at https://doi.org/10.1192/bjo.2022.543.
Data availability
The data-sets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Acknowledgement
We thank Hanayo Sawada for supporting our review process and Dr Goto and Dr Ikebuchi for advising on family psychoeducation and psychiatric rehabilitation.
Author contributions
F.K. and N.W. were responsible for the conception and design of the review. F.K. wrote the manuscript. All authors carried out the literature search, performed data extraction, data analysis and assessment of risk of bias, and drafted the manuscript. All authors have read and approved the final manuscript.
Funding
This study was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI grant number JP19H03936 from the Japanese Ministry of Education, Science and Technology.
Declaration of interest
F.K. has received speaker's fees from Otsuka Pharmaceutical. N.W. has received royalties from Sogensha, Medical View, and Advantage Risk Management for writings. A.Y. has received medical fees from Gifu Hospital, speaker's fees from Aichi Education and Sports Foundation, Kyowa Pharmaceutical Industry, Meiji Seika Pharma, the Mental Care Association of Japan, Otsuka Pharmaceutical, Shionogi & Co and Nobelpharma, royalties from Igaku-shoin, other fees from Nagoya City, Gifu City, Kani City and Nakatsugawa City, and grants from the Japanese Ministry of Education, Science and Technology.
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