Hostname: page-component-5cf477f64f-bmd9x Total loading time: 0 Render date: 2025-03-31T04:48:54.986Z Has data issue: false hasContentIssue false

Development of a Multiuser Interactive Health Response Application (MITHRA) for depression in women from a community-based organisation in India

Published online by Cambridge University Press:  25 March 2025

Johnson-Pradeep Ruben
Affiliation:
St John’s Medical College, Bengaluru, India St John’s Research Institute, Bengaluru, India
Dhinagaran Devadass
Affiliation:
St John’s Research Institute, Bengaluru, India
B. Ramakrishna Goud
Affiliation:
St John’s Medical College, Bengaluru, India
Yesenia Navarro-Aguirre
Affiliation:
Department of Anthropology, University of Washington, Seattle, Washington, USA
Bharat Kalidindi
Affiliation:
St John’s Research Institute, Bengaluru, India
Abijeet Waghmare
Affiliation:
St John’s Research Institute, Bengaluru, India
Tony Raj
Affiliation:
St John’s Medical College, Bengaluru, India St John’s Research Institute, Bengaluru, India
Krishnamachari Srinivasan
Affiliation:
St John’s Medical College, Bengaluru, India St John’s Research Institute, Bengaluru, India
Pamela Y. Collins
Affiliation:
Department of Global Health, University of Washington, Seattle, Washington, USA Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
Amritha Bhat*
Affiliation:
Department of Global Health, University of Washington, Seattle, Washington, USA Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
*
Correspondence: Amritha Bhat. Email: [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Background

In India, women in rural areas have high rates of depression. They have poor access to mental healthcare resources and, hence, mental health symptoms remain largely unaddressed. Existing mobile telephone applications (apps) do not engage end-users, lack local language options, may not be socioculturally relevant and do not use audiovisual formats. We thus developed a mobile mental health app, Multiuser Interactive Health Response Application (MITHRA), to screen and provide brief behavioural intervention for mild to moderate depression among rural women attending self-help groups (SHGs) in India.

Aims

This qualitative study explores the process and findings of focus groups conducted with SHG administrators and women to inform the iterative development of the MITHRA app.

Method

In total, 22 participants were interviewed (17 SHG participants and five administrators), and a thematic analysis of the data was conducted using the acceptability of interventions framework.

Results

Frequent themes across the focus groups were affective attitude, burden, self-efficacy and perceived effectiveness. All women showed a positive attitude towards the app and depression interventions, while older women demonstrated less self-efficacy in using mobile mental health apps.

Conclusions

MITHRA is a promising app in the management of mild to moderate depression in women in SHG. With adequate training and education of family members, MITHRA has the potential to identify and treat women with mild to moderate depression.

Type
Paper
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

Mental health is an important determinant of quality of life; however, it is often neglected, especially in women. One in ten women in rural India experiences common mental disorders such as anxiety and depression and, due to poor access to mental healthcare resources, these mental health symptoms remain largely unaddressed. Reference Srinivasan, Reddy, Sarkar and Menon1 Screening and treatment for depression through brief interventions using available resources is one way to address this treatment gap. Reference Pathare, Brazinova and Levav2 Mobile applications (apps) could play an important role: mobile app-based electronic decision support systems for healthcare workers are associated with improved mental health outcomes, including increased access to mental health services, reduced stigma and improved quality of life among rural Indian women. Reference Maulik, Kallakuri, Devarapalli, Vadlamani, Jha and Patel3 However, most apps available for patient use in India are focused on conditions such as diabetes or hypertension, with no culturally appropriate apps for mental health. Reference Maulik, Devarapalli, Kallakuri, Praveen, Jha and Patel4 Mental health apps have mainly been focused on physicians and community health workers Reference Maulik, Devarapalli, Kallakuri, Praveen, Jha and Patel4 to date, and not on women with depression or anxiety.

Multiuser Interactive Health Response Application (MITHRA)

In response to this need, we developed a mobile mental health app, MITHRA, to screen and provide brief behavioural intervention for depression among rural women attending self-help groups (SHGs) in India. Reference Bhat, Goud, Pradeep, Jayaram, Radhakrishnan and Srinivasan5 Women in rural India have limited access to smartphones due to shared ownership of phones, Reference Bhat, Goud, Pradeep, Jayaram, Radhakrishnan and Srinivasan5 and the app was intended to be used on a tablet shared among women attending SHGs. This app was iteratively developed based on feedback collected from focus group discussions with SHG members and administrators. These focus groups helped us obtain end-users’ input in app development, including input on app structure, content, design and quality. The mobile app termed MITHRA (see screenshots in Fig. 1), which means ‘friend’ in the regional language Kannada, will support the identification, initial treatment and referral of women with depression and is designed to address barriers such as illiteracy and lack of access to a personal mobile device. Women will complete depression screening using patient health questionnaire PHQ-9. Reference Kroenke and Spitzer6 Based on the severity of scores, the app will deliver different modules, including education about depression and activity scheduling, based on the healthy activity programme (HAP), a short, evidence-based psychological intervention that is acceptable, efficacious and cost-effective in the treatment of depression and has been tested in rural India. Reference Dimidjian, Barrera, Martell, Munoz and Lewinsohn7,Reference Patel, Weobong, Weiss, Anand, Bhat and Katti8 Modules will include instructions on managing stress, breathing techniques, improving sleep, getting active and problem-solving. This ensures that most women with mild to moderate depression receive initial treatment without having to overcome transportation barriers. Women with severe depression will receive instructions on how to contact the primary health centre for treatment. If suicidal ideation is endorsed (question 9 on PHQ-9), the community health worker will receive an alert to assess for imminence and to ensure the appropriate level of follow-up. This paper describes the process and findings of the focus groups conducted to inform the iterative development of the MITHRA app. We aimed to conduct focus group discussions (FGDs) to obtain the perspectives of SHG participants and administrators on the use of an app in identifying and treating depression among SHG participants.

Fig. 1 Multiuser Interactive Health Response Application (MITHRA) screenshots.

Method

Study site

The study was conducted in Anekal taluk (subdistrict administrative block of a state in India), Karnataka, which is approximately 25 miles from Bengaluru. It has a population of 517,575, with 48% being female. Among the 40 villages in Anekal taluk, with a total population of 9724, ten have functional women’s SHGs (https://villageinfo.in/karnataka/bangalore/anekal/m-medihalli.html). SHGs are run by the Centre for Integral Rural Welfare (CIRW), a non-governmental organisation that works with marginalised women to empower them. The primary aim of CIRW is to help people become agents of social change. As a part of this mission, it supports schools and provides training to women through tailoring institutes. In the community, CIRW manages more than 40 women’s SHGs to facilitate microfinancing and social empowerment.

Research team

The FGDs were facilitated by J.-P.R. and B.R.G., male members of the research team. J.-P.R. (MD in Psychiatry) is a consultant psychiatrist, B.R.G. (MD in Community Medicine) is a public health consultant, D.D. (BDS and MBA-HCS) is the information technology consultant, B.K. (BAMS and MPH) is a research coordinator for this study and A.W. (MBBS, Adv. Dip. in Bioinformatics, MBA) is an information technology consultant. All researchers were trained in qualitative research methodology. The FGD facilitators and first authors are aware of their positionality as clinicians who have been working to deliver healthcare to women in rural India. FGD participants of the SHG did not know any of the researchers; they were briefed by their leaders about the purpose of the FGD. FGD participants, comprising administrators, knew the researchers well.

Theoretical framework

We used the theoretical framework of acceptability, Reference Sekhon, Cartwright and Francis9 which includes seven component constructs: affective attitude, burden, ethicality, intervention coherence, opportunity costs, perceived effectiveness and self-efficacy. These constructs were used to develop themes for the thematic analysis. Affective attitude is defined as ‘how an individual feels about taking part in an intervention’. Burden is the perceived amount of effort required to participate in the intervention. Ethicality refers to how well the intervention fits within the respondents’ value system. Intervention coherence refers to the extent to which the participant understands the intervention and how it works. Opportunity cost is the extent to which benefits, profits or values must be given up to engage in the intervention. Perceived effectiveness is the extent to which the intervention is perceived as likely to achieve its purpose. Self-efficacy refers to the participant’s confidence that they can perform the behaviour(s) required to participate in the intervention.

Participants

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation, and with the Helsinki Declaration of 1975 as revised in 2008. All procedures involving human subjects/patients were approved by the University of Washington and St. Johns’ Research Institute, in June and August 2020 respectively.

We used purposive sampling to recruit female SHG participants, residents of the village and community health workers and administrators of the SHGs who had been in their current role for at least 6 months. Women diagnosed with a severe mental illness such as bipolar disorder or schizophrenia, and those with a history of suicide attempt or severe alcohol or substance use in the previous 6 months, were excluded because the intended use of the app is for treatment of mild to moderate depressive symptoms. Those who were unable to participate in the informed consent discussion were also excluded. Written informed consent was obtained face to face from all participants.

Participants were recruited via (a) advertisements, (b) flyers, (c) word of mouth and (d) community health workers (CHWs). CHWs were recruited from SHGs by contacting them through the parent CIRW. Across two focus groups for SHG women there were 17 participants, and in one focus group for administrators there were five participants (two males and three females). Based on previous research, this sample size is expected to support reaching saturation of data collected. Reference Guest, Namey and Chen10 Participants for the administrator group were recruited on 30 November 2021, and SHG participants on 21 December 2021.

Data collection

We developed an interview guide (see Supplementary Material available at https://doi.org/10.1192/bjo.2025.8) with questions and probes based on the theoretical framework of acceptability. We conducted three FGDs, two with SHG participants and one with SHG community health workers and administrators, each lasting 60 min. In FGDs with SHG participants, we obtained inputs on the design and features of the proposed app to be installed on a tablet, including specifications such as audio enablement, simplified touchscreen and a follow-up decision algorithm. We also included questions about screening for depression using PHQ-9, length of modules to be viewed and women’s preferences regarding viewing HAP modules at home or at the SHG. All FGDs were conducted in the office space of Jnana Jyothi (CIRW) on the same day, but in three different private rooms. FGDs were audio recorded, transcribed, translated into English and cross-verified by the researchers who conducted the FGD. Field notes were made and reviewed during coding and analysis.

Data analysis

Each transcript was reviewed by two coders. We used Dedoose version 9.2.22 (a cloud application for managing, analysing, and presenting qualitative and mixed method research data: SocioCultural Research Consultants, LLC, Los Angeles, CA, USA; www.dedoose.com) for analysis, and a thematic analysis approach using constructs from the theoretical framework of acceptability to code transcripts, generating new codes as needed. Discrepancies in coding were discussed and, based on the consensus of all reviewers, themes were merged or a new theme was generated. We used the Consolidated criteria for reporting qualitative research checklist for the reporting of qualitative research.

Trial registry

The study is registered in the Clinical Trial Registry of India (no. CTRI/2020/12/029844, registered 16 December 2020) and at clinicaltrials.gov (no. NCT04480021).

Results

Description of study sample

More than 50% of SHG participants in the study were aged 30–50 years. The majority were uneducated (49%), were involved in unskilled labour and worked for daily wages (55%); more than half had a household income of less than Rs. 15 000 per month. Notably, the age range of participants varied considerably between the two FGDs of SHG members. In group A, most of the participants were younger (42.9% aged 18–26 years), while in Group B, 50% were aged 28–34 years. Participant characteristics are shown in Table 1.

Table 1 Demographics of FGD participants (SHG women)

FGD, focus group discussion; SHG, self-help group; PUC, pre-university course; NA, not applicable; Rs, Rupees.

Five administrators from CIRW were part of the focus group; all were educated and serving various roles in the organisation including coordinator, teacher and director. None had previous training in mental health work. Administrator characteristics are shown in Table 2.

Table 2 Demographics of FGD participants (SHG administrators)

FGD, focus group discussion; SHG, self-help group.

The results of our analysis of the three focus groups are summarised in Table 3. The most frequent themes across the focus groups were affective attitude (25 codes), burden (21 codes) and self-efficacy (15 codes). Another frequent theme was perceived effectiveness related to app usage (19 codes).

Table 3 Themes, subthemes and sample quotes

Quotes are from both administrators (Admin.) and self-help group (SHG) women.

Affective attitude

In general, we found a positive attitude toward mobile devices and the proposed intervention among participants, with some indication of needing to leave devices with a responsible individual for safekeeping. Participants were hesitant to use electronic devices at home due to lack of familiarity, and fear of damaging the device, preferring to defer the use of tablets to the group setting, with supervision from leadership:

‘There is a fear of ruining digital objects if they are touched.’

Burden

That is, the perceived amount of effort required to participate in the intervention, which was higher among older users or those with lower digital literacy:

‘… old people find it difficult’.

Ethicality

Overall, the intervention (app-based screening and brief behavioural intervention) was reported to fit well within the value system of SHG members. However, participants (administrators) noted that the question about suicidal ideation included in PHQ-9 was dissonant with the community setting and the purpose of their gathering. Participants reported on a previous project wherein high school students were asked PHQ-9 questions, and the teachers became offended to the extent that ‘they were about to hit us’:

‘The last question. about suicide, it will be difficult for them.’

Intervention coherence

Suggestions made to increase intervention coherence included providing education and using story-telling and multimedia to enhance understanding:

‘Tell them what is depression … once people are mentally prepared then we can ask them questions’.

Opportunity cost

Rather than their own concerns about opportunity costs, participants were concerned about their family members perceiving them to be wasting time if they were to use the app too frequently:

‘… they are doing this instead of household chores’.

Perceived effectiveness

Although SHG members’ expectations of perceived effectiveness may have been low at the outset, education and word of mouth can enhance perceived effectiveness:

‘When they say it to the people it is for their good, confidence is gained …’

Self-efficacy

Several participants noted that confidence in using the app varied with age, with older women having more difficulty participating in an app-based intervention. This could be addressed with both training and practice:

‘People who are older than 60 years – using smartphones is difficult for them.’

In addition to the above codes based on the theoretical framework of acceptability, the following new theme emerged:

Accessibility

We defined accessibility as participants’ ability to utilise the intervention without external constraints on when, where, how and how much they use it. We found that accessibility to mobile devices was variable across participants, based on age and gender. In general, women – specifically older women – appeared to have reduced access to smartphones and mobile devices. This theme emerged in both participant and administrator FGDs. Although the use of a collectivist device such as a tablet with a multiuser app could be a solution to this, FGD administrators indicated that women’s families may be a barrier to their access of the device or the intervention:

‘Those who are in poverty, they have mobile phones but still not available for girls.’

Discussion

In India, as in other low- and middle-income countries, there is a huge gender gap in the ownership and patterns of mobile telephone and internet usage among women. 11 The situation in rural areas is worse, where rural women’s access to mobile telephones is far lower than that of their urban counterparts. Reference Mohan, Bashingwa, Tiffin, Dhar, Mulder and George12 In rural India, despite the ‘freedom’ given to them (women can use telephones without needing permission), women were found to be subjected to significant constraints directly through (a) narrow expectations and desires around how women would use telephones; (b) women’s dependence on men for telephone ownership and lower proximity to phones; (c) the poorer functionality of women’s telephones; (d) women’s limited digital skills; and (e) time allocation constraints, wherein women had less leisure time and were subject to social norms that discouraged the use of a telephone for leisure. Reference Scott, Shinde, Ummer, Yadav, Sharma and Purty13Reference Sagar and Pattanayak15 Similarly, we found that women in our study had low accessibility to mobile telephones, and the use a multiuser app in a community-based setting could address this barrier provided that family members were informed about the purpose of the app.

Mobile mental health is one way to address the large depression treatment gap in resource-constrained settings. However, available mental health apps often do not involve end-users in development and lack local language options and sociocultural relevance, and may not use audio and video formats to deliver content, Reference Sagar and Pattanayak15 limiting their usefulness. The MITHRA app is designed to address these limitations. It was developed in consultation with key end-users, is culturally appropriate (settings and characters in the video reflect the users), is available in the local language and is evidence based and client oriented.

Despite low accessibility, many of our participants demonstrated high self-efficacy in using digital interventions and a positive attitude towards mental health apps. This is perhaps a reflection of the initiative, Digital India, taken by the Indian government. This programme aims to make one person in every family e-literate, focusing on rural areas, by setting up state-wise training centres. An exploratory study on rural women in Vijayapura district (Karnataka) following implementation of this training found that many of the women perceived an improvement in their self-confidence (41.04%, n = 744) and knowledge (48.10%, n = 872) with regard to the use of mobile devices. Reference Kakade and Tattimani16 However, we found age-related differences in self-efficacy with regard to digital interventions. Women older than 60 years of age were reported to use telephones only for making or receiving calls and were not familiar with smartphones. Training and technical assistance for these users could increase their confidence in using the app. Other features of the MITHRA app were developed specifically in response to feedback received in FGDs. For example, privacy was ensured by providing headphones, and accessibility was enhanced with audio versions of screening questions for illiterate users. Video modules were kept concise, respecting the limited free time available to the women, and were narrated in local languages to enhance engagement and comprehension.

There is limited evidence on the ethical issues involving the use of mental health intervention apps in rural India. Issues such as data privacy and confidentiality need to be explored, especially when deploying mental health apps in community-based settings. The inclusion of screening in mental health apps without paying attention to symptom severity may lead to stigma or unnecessary treatment-seeking behaviours, burdening already strained systems in low-resource settings. Reference Carter, Rogers, Heath, Degeling, Doust and Barratt17 Given our participants’ opinion that questions about suicide feel incongruent in a community setting, in future iterations of the app we may use different depression screeners that do not include questions about suicidal ideation.

Strengths and limitations

This qualitative study explored women’s knowledge of, and ease of using, smartphone applications, and gathered inputs on the design and features of the proposed app. These end-user inputs have helped us develop a mental health app that is responsive to the needs of the proposed audience for the app, culturally appropriate (settings and characters in the video), available in the local language, evidence based, client oriented and with content in both audio and video format. Although we conducted only three FGDs, we did observe data saturation and continued to obtain end-user input as a subset of FGD participants, as our PDG is engaged in further iterative modification of the app. One limitation is that women who consented to the FGD may also be inherently more likely to use app-based treatments. Additionally, FGDs were conducted by male researchers, and female participants may have hesitated to share their thoughts openly.

The MITHRA app is, to our knowledge, the first to deliver depression screening and brief psychological intervention for women in SHGs in India. MITHRA has been developed with end-user input and is a promising tool in the management of mild to moderate depression. We found that older women demonstrated lower self-efficacy in using mobile mental health apps, but all women had a positive attitude towards the app and depression interventions. With adequate training, and education of family members, a multiuser app installed on a tablet available in SHGs has the potential to identify and treat women with depression. Future research should examine the effectiveness of apps such as MITHRA in treating mild to moderate depression.

Supplementary material

The supplementary material for this article can be found at https://doi.org/10.1192/bjo.2025.8

Data availability

The data that support the findings of this study are available on reasonable request from the corresponding author (A.B.). The data are not publicly available due to privacy/ethical restrictions.

Acknowledgements

We thank Dr Susan Thomas, Assistant Professor, Division of Mental Health and Neurosciences, St. John’s Research Institute for training the study team on conducting the focus group discussion. We thank Fr Kevin, Mr M. Vijay and Ms. Sushila from CIRW Jnana Jyoti for their support in facilitating the study activities and Ms Jayasudha N who voiced the avatars in the app.

Author contributions

J.-P.R., D.D., B.R.G., Y.N.-A., B.K., A.W., T.R., K.S., P.Y.C. and A.B. contributed to study conception, design, data collection, data analysis and approval of the final article, and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Funding

This work was supported by the National Institutes of Health (no. NIH 1R21MH124073) awarded to A.B. and K.S.

Declaration of interest

None.

Footnotes

*

Joint first author.

References

Srinivasan, M, Reddy, MM, Sarkar, S, Menon, V. Depression, anxiety, and stress among rural south Indian women—prevalence and correlates: a community-based study. J Neurosci Rural Pract 2020; 11: 7883.CrossRefGoogle ScholarPubMed
Pathare, S, Brazinova, A, Levav, I. Care gap: a comprehensive measure to quantify unmet needs in mental health. Epidemiol Psychiatr Sci 2018; 27: 463–7.CrossRefGoogle Scholar
Maulik, PK, Kallakuri, S, Devarapalli, S, Vadlamani, VK, Jha, V, Patel, A. Increasing use of mental health services in remote areas using mobile technology: a pre–post evaluation of the SMART Mental Health project in rural India. J Glob Health 2017; 7: 010408.CrossRefGoogle ScholarPubMed
Maulik, P, Devarapalli, S, Kallakuri, S, Praveen, D, Jha, V, Patel, A. Systematic Medical Appraisal, Referral and Treatment (SMART) mental health programme for providing innovative mental health care in rural communities in India. Glob Ment Health (Camb.) 2015; 2: e13.CrossRefGoogle Scholar
Bhat, A, Goud, BR, Pradeep, J, Jayaram, G, Radhakrishnan, R, Srinivasan, K. Can mobile health improve depression treatment access and adherence among rural Indian women? A qualitative study. Cult Med Psychiatry 2020; 44: 461–78.CrossRefGoogle ScholarPubMed
Kroenke, K, Spitzer, RL. The PHQ-9: a new depression diagnostic and severity measure. Psychiatr Ann 2002; 32: 509–15.CrossRefGoogle Scholar
Dimidjian, S, Barrera, M Jr, Martell, C, Munoz, RF, Lewinsohn, PM. The origins and current status of behavioral activation treatments for depression. Ann Rev Clin Psychol 2011; 7: 138.CrossRefGoogle ScholarPubMed
Patel, V, Weobong, B, Weiss, HA, Anand, A, Bhat, B, Katti, B, et al. The Healthy Activity Program (HAP), a lay counsellor-delivered brief psychological treatment for severe depression, in primary care in India: a randomised controlled trial. Lancet 2017; 389: 176–85.CrossRefGoogle Scholar
Sekhon, M, Cartwright, M, Francis, JJ. Acceptability of healthcare interventions: an overview of reviews and development of a theoretical framework. BMC Health Serv Res 2017; 17: 88.CrossRefGoogle ScholarPubMed
Guest, G, Namey, E, Chen, M. A simple method to assess and report thematic saturation in qualitative research. PLoS One 2020; 15: e0232076.CrossRefGoogle ScholarPubMed
Mohan, D, Bashingwa, JJH, Tiffin, N, Dhar, D, Mulder, N, George, A, et al. Does having a mobile phone matter? Linking phone access among women to health in India: an exploratory analysis of the national family health survey. PLoS One 2020; 15: e0236078.Google ScholarPubMed
Scott, K, Shinde, A, Ummer, O, Yadav, S, Sharma, M, Purty, N, et al. Freedom within a cage: how patriarchal gender norms limit women’s use of mobile phones in rural central India. BMJ Glob Health 2021; 6(suppl 5): e005596.Google ScholarPubMed
Ramnath, S, Suri, G. Managing depression in India: opportunities for a targeted smartphone app. Int J Soc Psychiatry 2021; 67: 1035–45.Google ScholarPubMed
Sagar, R, Pattanayak, RD. Use of smartphone apps for mental health: can they translate to a smart and effective mental health care? J Ment Health Hum Behav 2015; 20: 13.CrossRefGoogle Scholar
Kakade, O, Tattimani, D. The role of Digital India in rural women empowerment: a case study of Vijayapura District. IOSR J Hum Soc Sci 2021; 26: 3748.Google Scholar
Carter, SM, Rogers, W, Heath, I, Degeling, C, Doust, J, Barratt, A. The challenge of overdiagnosis begins with its definition. BMJ 2015; 350: h869.CrossRefGoogle ScholarPubMed
Figure 0

Fig. 1 Multiuser Interactive Health Response Application (MITHRA) screenshots.

Figure 1

Table 1 Demographics of FGD participants (SHG women)

Figure 2

Table 2 Demographics of FGD participants (SHG administrators)

Figure 3

Table 3 Themes, subthemes and sample quotes

Supplementary material: File

Ruben et al. supplementary material

Ruben et al. supplementary material
Download Ruben et al. supplementary material(File)
File 206 KB
Submit a response

eLetters

No eLetters have been published for this article.