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Adjunctive aripiprazole in risperidone-induced hyperprolactinaemia: double-blind, randomised, placebo-controlled trial

Published online by Cambridge University Press:  02 January 2018

G. Raghuthaman ,
R. Venkateswaran  and
R. Krishnadas
G. Raghuthaman
Affiliation:
Department of Psychiatry, PSG Institute of Medical Sciences and Research, Coimbatore, India
R. Venkateswaran
Affiliation:
Department of Child Psychiatry, CMC, Vellore, India
R. Krishnadas*
Affiliation:
ESTEEM, NHS Greater Glasgow and Clyde, Glasgow, UK
*
Rajeev Krishnadas, Department of Psychiatry, ESTEEM, Glasgow G21 4SF, UK. Email: [email protected]
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Abstract

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Background

Hyperprolactinaemia is a troublesome side-effect of treatment with antipsychotics.

Aims

This double-blind, placebo-controlled study aimed at examining the effect of adjunctive treatment with 10 mg aripiprazole on prolactin levels and sexual side-effects in patients with schizophrenia symptomatically maintained on risperidone.

Method

Thirty patients taking risperidone were enrolled into the trial (CTRI/2012/11/003114). Aripiprazole was administered at a fixed daily dose of 10 mg/day for 8 weeks. Serum prolactin was measured at baseline and at 8 weeks. Hyperprolactinaemia-related problems, psychopathology and side-effects were evaluated every 2 weeks.

Results

Prolactin levels decreased by 58% in the aripiprazole group compared with an increase by 22% in the placebo group. Prolactin levels normalised in 46% of patients in the aripiprazole group (number needed to treat, NNT=2). Aripiprazole improved erectile dysfunction in five out of six patients. There were no significant differences in change in psychopathology or side-effects between groups.

Conclusions

Adjunctive aripiprazole reduced prolactin levels in those treated with risperidone, with no effect on psychopathology and extrapyramidal symptoms. This is a potential treatment for hyperprolactinaemia observed during treatment with second-generation antipsychotics.

Type
Research Article
Information
BJPsych Open , Volume 1 , Issue 2 , October 2015 , pp. 172 - 177
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Copyright
Copyright © The Royal College of Psychiatrists 2015

Footnotes

Declaration of interest

None.

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