A number of plasma membrane receptor types originally thought to be specific to neurons have been found in other somatic cells. More surprisingly, the mammalian sperm and neuron appear to share many of these ‘neuronal’ receptors. The morphology, chromosome number, genomic activity, and functions of those two cell types are as unlike as any two cells in the body, but they both achieve their highly disparate goals with the aid of a number of the same receptors. Exocytosis in neurons and sperm is essential to the functions of these cells and is strongly influenced by similar receptors. ‘Neuronal’ receptor types in sperm may also play a role in the control of sperm motility (a function of course not shared by neurons).

This review will consider the evidence for the presence of sperm plasma membrane ‘neuronal’ receptors and for their significance to mammalian sperm function. The persuasiveness of the evidence varies depending on the receptor being considered, but there is strong experimental support for the presence and importance of a number of ‘neuronal’ receptors in sperm.