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Regulation of adenylyl cyclase in LTP

Published online by Cambridge University Press:  04 February 2010

Erik D. Roberson  and
J. David Sweatt
Erik D. Roberson
Affiliation:
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030. [email protected]. bcm.tmc.edu
J. David Sweatt
Affiliation:
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030. [email protected]. bcm.tmc.edu
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Abstract

Our results on hippocampal long-term potentiation are considered in the context of Xia et al.'s hypothesis. Whereas the target article proposes presynaptic PKC involvement in adenylyl cyclase activation by phosphorylation of nenromodulin, we suggest an additional postsynaptic role involving RC3/nenrogranin. Finally, we examine the possibility that the adenylyl cyclase mutant mouse may display normal learning with a selective impairment of memory.

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Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 485 - 486
Copyright
Copyright © Cambridge University Press 1995

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