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Recoverin is the tumor antigen in cancerassociated retinopathy

Published online by Cambridge University Press:  04 February 2010

Arthur S. Polans  and
Grazyna Adamus
Arthur S. Polans
Affiliation:
R S. Dow Neurological Sciences Institute, Legacy-Good Samaritan Hospital and Medical Center, Portland, OR 97209
Grazyna Adamus
Affiliation:
R S. Dow Neurological Sciences Institute, Legacy-Good Samaritan Hospital and Medical Center, Portland, OR 97209
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Abstract

Considerable progress has been made toward understanding the involvement of recoverin in a cancer-associated retinopathy (CAR) that results in blindness. We describe the expression of recoverin in tumors of individuals afflicted with CAR, characterize the immunological response towards recoverin in these patients, and demonstrate how the disease can be induced in rodents using recoverin as an immunogen.

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Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 483 - 484
Copyright
Copyright © Cambridge University Press 1995

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