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No more news from the cerebellum
Published online by Cambridge University Press: 19 May 2011
Abstract
Although a number of further studies have now been published exploring possible roles for the NO-cGMP signal transduction system in various models of LTD, there still appears to be confusion regarding the physiological functions of these molecules in the cerebellar cortex. What seems clear is that NO can be produced in granule cells and basket cells, and can stimulate soluble guanylyl cyclase, thereby activating cGMP-dependent protein ldnase in Purkinje cells. However, substrates for this Idnase are still poorly defined, and its role in the modulation of synaptic transmission remains to be determined. The recent development of novel transgenic models and new pharmacological agents with which to dissect this signal transduction system, gives one confidence that our understanding of the cerebellar NO system will quickly advance. With its unique properties as a signaling molecule, it is clear that NO news has been good news for those studying synaptic plasticity in the cerebellum.
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- Copyright © Cambridge University Press 1996