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Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis

Published online by Cambridge University Press:  19 July 2005

Clive R. Bramham
Clive R. Bramham*
Affiliation:
Department of Biomedicine and Locus on Neuroscience, University of Bergen, N-5009Bergen, Norwayhttp://www.uib.no/med/biomed/research/bramham/
*
[email protected]
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Abstract

Insights into the role of sleep in the molecular mechanisms of memory consolidation may come from studies of activity-dependent synaptic plasticity, such as long-term potentiation (LTP). This commentary posits a specific contribution of sleep to LTP stabilization, in which mRNA transported to dendrites during wakefulness is translated during sleep. Brain-derived neurotrophic factor may drive the translation of newly transported and resident mRNA.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 28 , Issue 1 , February 2005 , pp. 65 - 66
Copyright
Copyright © Cambridge University Press 2005

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