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The limitations of central nervous systemdirected gene transfer

Published online by Cambridge University Press:  04 February 2010

Beverly L. Davidson
Beverly L. Davidson
Affiliation:
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0680. [email protected]
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Abstract

Complementation and correction of a genetic defect with CNS manifestations lags behind gene therapy for inherited disorders affecting other organ systems because of shortcomings in delivery vehicles and access to the CNS. The effects of improvements in viral and nonviral vectors, coupled with the development of delivery strategies designed to transfer genetic material thoughout the CNS are being investigated by a number of laboratories in efforts to overcome these problems.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 54 - 55
Copyright
Copyright © Cambridge University Press 1995

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