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The determination of rhodopsin structure may require alternative approaches

Published online by Cambridge University Press:  04 February 2010

Arlene D. Albert  and
Philip L. Yeagle
Arlene D. Albert
Affiliation:
Department of Ophthalmology, University at Buffalo School of Medicine (SUNY), Buffalo, NY 14214. [email protected] Department of Biochemistry, University at Buffalo School of Medicine (SUNY), Buffalo, NY 14214. [email protected]
Philip L. Yeagle
Affiliation:
Department of Biochemistry, University at Buffalo School of Medicine (SUNY), Buffalo, NY 14214. [email protected]
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Abstract

The structure of rhodopsin is a subject of intense interest. Solving the structure by traditional methods has proved exceedingly challenging. It may therefore be useful to confront the problem by a combination of alternate techniques. These include FTIR (Fourier transform infrared spectroscopy) and AFM (atomic force microscopy) on the intact protein. Furthermore, additional insights may be gained through structural investigations of discrete rhodopsin domains.

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Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 469
Copyright
Copyright © Cambridge University Press 1995

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