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An evolutionary framework for mental disorders: Integrating adaptationist and evolutionary genetic models

Published online by Cambridge University Press:  09 November 2006

Matthew C. Keller  and
Geoffrey Miller
Matthew C. Keller*
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonweatlh University, Richmond, VA23219www.matthewckeller.com
Geoffrey Miller*
Affiliation:
Department of Psychology, University of New Mexico, Albuquerque, NM87131-1161www.unm.edu/~psych/faculty/gmiller.html
*
[email protected]
[email protected]
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Abstract:

This response (a) integrates non-equilibrium evolutionary genetic models, such as coevolutionary arms-races and recent selective sweeps, into a framework for understanding common, harmful, heritable mental disorders; (b) discusses the forms of ancestral neutrality or balancing selection that may explain some portion of mental disorder risk; and (c) emphasizes that normally functioning psychological adaptations work against a backdrop of mutational and environmental noise.

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Authors' Response
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Behavioral and Brain Sciences , Volume 29 , Issue 4 , August 2006 , pp. 429 - 452
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Copyright © Cambridge University Press 2006

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