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Structure and physiology of photoreceptor cGMP-gated cation channels

Published online by Cambridge University Press:  04 February 2010

Lawrence W. Haynes*
Affiliation:
Department of Medical Physiology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. [email protected]

Abstract

The primary sequence of two subunits of the rod and one subunit of the cone cGMP-gated channel have been described, but describing how structure determines function is only just beginning. The discovery that the affinity of the rod channel for its agonist can be modulated indicates that the relationship between intracellular cGMP and the channel's open probability (current) during the course of the photoresponse may be more complex than previously thought.

Type
Article Commentary
Copyright
Copyright © Cambridge University Press 1995

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