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Piece of mind; a full systems approach is required

Published online by Cambridge University Press:  26 July 2007

Caroline Rae
Affiliation:
Prince of Wales Medical Research Institute, The University of New South Wales, Randwick, NSW 2031, Australia. [email protected]://www.powmri.edu.au/staff/rae.htm

Abstract

Intelligence studies are confounded by an inability to image the mind, as well as by heterogeneity in intelligence constructs, gender, and age. The ghost (of future, not past) sitting at the table is a molecular one. Biochemistry and molecular biology factors can contribute to or take away from intelligence to a great and not yet fully explored extent.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2007

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References

Benbow, C. P. & Stanley, J. C. (1983) Sex differences in mathematical reasoning ability: More facts. Science 222:1029–31.CrossRefGoogle ScholarPubMed
Benga, O. (2006) Heterogeneity in fluid cognition and some neural underpinnings. Behavioral and Brain Sciences 29:126.CrossRefGoogle Scholar
Coltheart, M. (2006) What has functional neuroimaging told us about the mind (so far)? Cortex 42:323–31.CrossRefGoogle ScholarPubMed
Cutter, W. J., Daly, E. M., Robertson, D. M. W., Chitnis, X. A., van Amerlsvoort, T. A. M. J., Simmons, A., Ng, V. W. K., Williams, B. S., Shaw, P., Conway, G. S., Skuse, D. H., Collier, D. A., Craig, M. & Murphy, D. G. M. (2006) Brain development: A magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndrome. Biological Psychiatry 59:273–83.CrossRefGoogle ScholarPubMed
Davies, W., Isles, A. R. & Wilkinson, L. S. (2005) Imprinted gene expression in the brain. Neuroscience and Biobehavioral Reviews 29:421–30.CrossRefGoogle ScholarPubMed
Davies, W. & Wilkinson, L. S. (2006) It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Research 1126:3645.CrossRefGoogle ScholarPubMed
Deary, I. J., Bastin, M. E., Pattie, A., Clayden, J. D., Whalley, L. J., Starr, J. M. & Wardlaw, J. M. (2006) White matter integrity and cognition in childhood and old age. Neurology 66:505–12.CrossRefGoogle ScholarPubMed
Gustafson, S. & Samuelsson, S. (1999) Intelligence and dyslexia: Implications for diagnosis and intervention. Scandinavian Journal of Psychology 40:127–34.Google ScholarPubMed
Jung, R. E., Brooks, W. M., Yeo, R. A., Chiulli, S. J., Weers, D. C. & Sibbitt, W. L. Jr. (1999) Biochemical markers of intelligence: A proton MR spectroscopy study of normal human brain. Proceedings of the Royal Society of London; Series B; Biological Sciences 266(1426):1375–79.CrossRefGoogle ScholarPubMed
Kantha, S. S. (1992) Albert Einstein's dyslexia and the significance of Brodmann Area 39 of his left cerebral cortex. Medical Hypotheses 37:119–22.CrossRefGoogle ScholarPubMed
Mabbott, D. J., Noseworthy, M., Bouffet, E., Laughlin, S. & Rockel, C. (2006) White matter growth as a mechanism of cognitive development in children. NeuroImage 33:936–46.CrossRefGoogle ScholarPubMed
Rae, C., Digney, A. L., McEwan, S. R. & Bates, T. C. (2003a) Oral creatine monohydrate supplementation improves cognitive performance; a placebo-controlled, double blind, cross-over trial. Proceedings of the Royal Society of London, Series B: Biological Sciences 279:2147–50.CrossRefGoogle Scholar
Rae, C., Joy, P., Harasty, J., Kemp, A., Kuan, S., Christodoulou, J., Cowell, C. T. & Coltheart, M. (2004) Enlarged temporal lobes in Turner syndrome. An X-chromosome effect? Cerebral Cortex 14:156–64.CrossRefGoogle ScholarPubMed
Rae, C., Lee, M. A., Dixon, R. M., Blamire, A. M., Thompson, C. H., Styles, P., Talcott, J., Richardson, A. J. & Stein, J. F. (1998) Metabolic abnormalities in developmental dyslexia detected by 1H magnetic resonance spectroscopy. Lancet 351(9119): 1849–52.CrossRefGoogle ScholarPubMed
Rae, C., Scott, R. B., Lee, M., Simpson, J. M., Hines, N., Paul, C., Anderson, M., Karmiloff-Smith, A., Styles, P. & Radda, G. K. (2003b) Brain bioenergetics and cognitive ability. Developmental Neuroscience 25(5): 324–31.CrossRefGoogle ScholarPubMed
Rumsey, J. M., Andeason, P., Zametkin, A. J., Aquino, T., King, A. C., Hamburger, S. D., Pikus, A., Rapoport, J. L. & Cohen, R.M. (1992) Failure to activate the left temporo-parietal cortex in dyslexia: An oxygen15 positron emission tomographic study. Archives of Neurology 49:527–34.CrossRefGoogle Scholar
Rutter, M., Caspi, A., Fergusson, D., Horwood, L. J., Goodman, R., Maughan, B., Moffitt, T. E., Meltzer, H. & Carroll, J. (2004) Sex differences in developmental reading disability. Journal of the American Medical Association 291:2007–12.CrossRefGoogle ScholarPubMed
Rypma, B., Berger, J. S., Prabhakaran, V., Bly, B. M., Kimberg, D. Y., Biswal, B. B. & D'Esposito, M. (2006) Neural correlates of cognitive efficiency. NeuroImage 33(3):969–79.CrossRefGoogle ScholarPubMed
Schmithorst, V. J. & Holland, S. K. (2006) Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls. NeuroImage 31(3):1366–79.CrossRefGoogle ScholarPubMed
Seron, X. & Fias, W. (2006) How images of the brain can constrain cognitive theory: The case of numerical cognition. Cortex 42:406–10.CrossRefGoogle ScholarPubMed
Sternberg, R. J. (1990) Metaphors of mind: Conceptions of the nature of intelligence. Cambridge University Press.Google Scholar
Winterer, G., Musso, F., Vucurevic, G., Stoeter, P., Konrad, A., Seker, B., Gallinat, J., Dahmen, N. & Weinberger, D. R. (2006) COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. NeuroImage 32:1722–32.CrossRefGoogle ScholarPubMed