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Mechanisms of photoreceptor degenerations

Published online by Cambridge University Press:  04 February 2010

Colin J. Barnstable
Colin J. Barnstable*
Affiliation:
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520-8061. colin_barnstable@quickmail.yale.edu
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Abstract

The candidate gene approach has identified many causes of photoreceptor rod cell death in retinitis pigmentosa. Some mutations lead to increased cyclicGMP concentrations in rods. Rod photoreceptors are also particularly susceptible to some mutations in housekeeping genes. Although many more cases of macular degeneration than retinitis pigmentosa occur each year, there is much less known about both genetic and sporadic forms of this disease.

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Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 470
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Copyright © Cambridge University Press 1995

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