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Intraretrosplenial grafts of cholinergic neurons and spatial memory function

Published online by Cambridge University Press:  04 February 2010

Ying J. Li  and
Walter C. Low
Ying J. Li
Affiliation:
Departments of Neurosurgery
Walter C. Low
Affiliation:
Departments of Neurosurgery Departments of Physiology Departments of Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. [email protected]
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Abstract

The transplantation of cholinergic neurons into the hippocampal formation has been well characterized. We describe our studies on the effects of cholinergic transplants in the retrosplenial cortex. These transplants were capable of ameliorating spatial navigation deficits in rats with septohippocampal lesions. In addition, we provide evidence for the modulation of transplanted neurons by the host brain.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 61 - 62
Copyright
Copyright © Cambridge University Press 1995

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