Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-26T06:00:04.274Z Has data issue: false hasContentIssue false
  • English
  • Français

Genomic imprinting and disorders of the social brain; shades of grey rather than black and white

Published online by Cambridge University Press:  26 June 2008

William Davies  and
Anthony R. Isles
William Davies
Affiliation:
Behavioural Genetics Group, Department of Psychological Medicine, School of Medicine and School of Psychology, University of Cardiff, Cardiff CF14 4XN, United Kingdom. [email protected]://www.cardiff.ac.uk/medic/contactsandpeople/d/[email protected]://www.cardiff.ac.uk/medic/contactsandpeople/i/isles-anthony-roger-overview_new.html
Anthony R. Isles
Affiliation:
Behavioural Genetics Group, Department of Psychological Medicine, School of Medicine and School of Psychology, University of Cardiff, Cardiff CF14 4XN, United Kingdom. [email protected]://www.cardiff.ac.uk/medic/contactsandpeople/d/[email protected]://www.cardiff.ac.uk/medic/contactsandpeople/i/isles-anthony-roger-overview_new.html
Get access Rights & Permissions [Opens in a new window]

Abstract

Crespi & Badcock (C&B) provide a novel hypothesis outlining a role for imprinted genes in mediating brain functions underlying social behaviours. The basic premise is that maternally expressed genes are predicted to promote hypermentalistic behaviours, and paternally expressed genes hypomentalistic behaviours. The authors provide a detailed overview of data supporting their ideas, but as we discuss, caution should be applied in interpreting these data.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 31 , Issue 3 , June 2008 , pp. 265 - 266
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boer, H., Holland, A., Whittington, J., Butler, J., Webb, T. & Clarke, D. (2002) Psychotic illness in people with Prader-Willi syndrome due to chromosome 15 maternal uniparental disomy. Lancet 359(9301):135–36.CrossRefGoogle ScholarPubMed
Brown, W. M. & Consedine, N. S. (2004) Just how happy is the happy puppet? An emotion signaling and kinship theory perspective on the behavioral phenotype of children with Angelman syndrome. Medical Hypotheses 63(3):377–85.CrossRefGoogle ScholarPubMed
Dimitropoulos, A. & Schultz, R. T. (2007) Autistic-like symptomatology in Prader-Willi syndrome: A review of recent findings. Current Psychiatry Reports 9(2):159–64.CrossRefGoogle ScholarPubMed
Francks, C., Maegawa, S., Lauren, J., Abrahams, B. S., Velayos-Baeza, A., Medland, S. E., Colella, S., Groszer, M., McAuley, E. Z., Caffrey, T. M., Timmusk, T., Pruunsild, P., Koppel, I., Lind, P. A., Matsumoto-Itaba, N., Nicod, J., Xiong, L., Joober, R., Enard, W., Krinsky, B., Nanba, E., Richardson, A. J., Riley, B. P., Martin, N. G., Strittmatter, S. M., Moller, H. J., Rujescu, D., St Clair, D., Muglia, P., Roos, J. L., Fisher, S. E., Wade-Martins, R., Rouleau, G. A., Stein, J. F., Karayiorgou, M., Geschwind, D. H., Ragoussis, J., Kendler, K. S., Airaksinen, M. S., Oshimura, M., Delisi, L. E. & Monaco, A. P. (2007) LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Molecular Psychiatry 12(12):1129–39, 1057.CrossRefGoogle ScholarPubMed
Haig, D. (2000a) Genomic imprinting, sex-biased dispersal, and social behavior. In: Evolutionary perspectives on human reproductive behavior, ed. LeCroy, D. & Moller, P.. New York Academy of Sciences. Annals of the New York Academy of Sciences 907:149–63.Google Scholar
Isles, A. R., Davies, W. & Wilkinson, L. S. (2006) Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 361(1476):2229–37.CrossRefGoogle ScholarPubMed
Isles, A. R. & Holland, A. J. (2005) Imprinted genes and mother-offspring interactions. Early Human Development 81(1):73–77.CrossRefGoogle ScholarPubMed
Martin, C. L. & Ledbetter, D. H. (2007) Autism and cytogenetic abnormalities: Solving autism one chromosome at a time. Current Psychiatry Reports 9(2):141–47.CrossRefGoogle ScholarPubMed
McDonald, C., Marshall, N., Sham, P. C., Bullmore, E. T., Schulze, K., Chapple, B., Bramon, E., Filbey, F., Quraishi, S., Walshe, M. & Murray, R. M. (2006) Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives. American Journal of Psychiatry 163(3):478–87.CrossRefGoogle ScholarPubMed
Wilkinson, L. S., Davies, W. & Isles, A. R. (2007) Genomic imprinting effects on brain development and function. Nature Reviews. Neuroscience 8(11):832–43.CrossRefGoogle Scholar