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Gene therapy for neurodegenerative disorders and malignant brain tumors

Published online by Cambridge University Press:  04 February 2010

Lan Chiang ,
Eric P. Flores ,
Dennis Y. Wen ,
Walter A. Hall  and
Walter C. Low
Lan Chiang
Affiliation:
Departments of NeurosurgeryUniversity of MinnesotaMedical School, Minneapolis, MN 55455. [email protected]
Eric P. Flores
Affiliation:
Departments of NeurosurgeryUniversity of MinnesotaMedical School, Minneapolis, MN 55455. [email protected]
Dennis Y. Wen
Affiliation:
Departments of NeurosurgeryUniversity of MinnesotaMedical School, Minneapolis, MN 55455. [email protected]
Walter A. Hall
Affiliation:
Departments of NeurosurgeryUniversity of MinnesotaMedical School, Minneapolis, MN 55455. [email protected]
Walter C. Low
Affiliation:
Departments of NeurosurgeryUniversity of MinnesotaMedical School, Minneapolis, MN 55455. [email protected] Departments of PhysiologyUniversity of MinnesotaMedical School, Minneapolis, MN 55455. Departments of Program in Neuroscience, University of MinnesotaMedical School, Minneapolis, MN 55455. [email protected]
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Abstract

Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 52 - 53
Copyright
Copyright © Cambridge University Press 1995

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