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Finland's Galapagos: Founder effect, drift, and isolation in the inheritance of susceptibility alleles

Published online by Cambridge University Press:  09 November 2006

Tom Campbell ,
Daria Osipova  and
Seppo Kähkönen
Tom Campbell*
Affiliation:
Helsinki Collegium for Advanced Studies, University of Helsinki, FIN-00014Helsinki, Finlandhttp://www.mv.helsinki.fi/home/campbell/
Daria Osipova*
Affiliation:
Cognitive Brain Research Unit, University of Helsinki, FIN-00014Helsinki, Finlandhttp://www.cbru.helsinki.fi/
Seppo Kähkönen*
Affiliation:
Cognitive Brain Research Unit, University of Helsinki, FIN-00014Helsinki, Finlandhttp://www.cbru.helsinki.fi/ BioMag Laboratory, Helsinki University Central Hospital, FIN-00290Helsinki, Finlandhttp://www.biomag.hus.fi/
*
[email protected]
[email protected]
[email protected]
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Abstract:

The target article excludes ancestral neutrality as a cause for the inheritance of schizophrenia, with an argument relating to selection against a single allele in the Finnish population. However, drift would predominate over selection within subisolates of the Finnish population. Comparisons of subisolates with heterogeneous populations may provide clues to the endophenotypic structure of complex polygenetic heritable mental disorders.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 29 , Issue 4 , August 2006 , pp. 409 - 410
Copyright
Copyright © Cambridge University Press 2006

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