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Dopamine, Parkinson's disease, and volition

Published online by Cambridge University Press:  11 August 2003

Jon C. Horvitz
Jon C. Horvitz
Affiliation:
Department of Psychology, Columbia University, New York, NY 10027 [email protected] www.columbia.edu/~jh299
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Abstract

Disruptions in dopamine transmission within the basal ganglia (BG) produce deficits in voluntary actions, that is, in the interface between cortically-generated goal representation and BG-mediated response selection. Under conditions of dopamine loss in humans and other animals, responses are impaired when they require internal generation, but are relatively intact when elicited by external stimuli.

Type
Brief Report
Information
Behavioral and Brain Sciences , Volume 25 , Issue 5 , October 2002 , pp. 586
Copyright
© 2002 Cambridge University Press

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