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Cyclic nucleotides as regulators of light-adaptation in photoreceptors

Published online by Cambridge University Press:  04 February 2010

Barry M. Willardson ,
Tatsuro Yoshida  and
Mark W. Bitensky
Barry M. Willardson
Affiliation:
Biophysics Group, Physics Division, Los Alamos National Laboratory, University of California, Los Alamos, NM 87545.
Tatsuro Yoshida
Affiliation:
Biophysics Group, Physics Division, Los Alamos National Laboratory, University of California, Los Alamos, NM 87545. [email protected]
Mark W. Bitensky
Affiliation:
Biophysics Group, Physics Division, Los Alamos National Laboratory, University of California, Los Alamos, NM 87545.
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Abstract

Cyclic nucleotides can regulate the sensitivity of retinal rods to light through phosducin. The phosphorylation state of phosducin determines the amount of G available for activation by Rho*. Phosducin phosphorylation is regulated by cyclic nucleotides through their activation of cAMP-dependent protein kinase. The regulation of phosphodiesterase activity by the noncatalytic cGMP binding sites as well as Ca2+/calmodulin dependent regulation of cGMP binding to the cation channel are also discussed.

Type
Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 493 - 494
Copyright
Copyright © Cambridge University Press 1995

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