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Calcium/calmodulin-sensitive adenylyl cyclase as an example of a molecular associative integrator

Published online by Cambridge University Press:  04 February 2010

Thomas W. Abrams
Thomas W. Abrams*
Affiliation:
Department of Neuroscience, University of Pennsylvania, Goddard Labs, Philadelphia, PA 19104-6018. [email protected]
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Abstract

Evidence suggests that the Ca2+/calmodulin-sensitive adenylyl cyclase may play a key role in neural plasticity and learning in Aplysia, Drosophila, and mammals. This dually-regulated enzyme has been proposed as a possible site of stimulus convergence during associative learning. This commentary discusses the evidence that is required to demonstrate that a protein in a second messenger cascade actually functions as a molecular site of associative integration. It also addresses the issue of how a dually-regulated protein could contribute to the temporal pairing requirements of classical conditioning: that relationship between stimuli display both temporal contiguity and predictability.

Type
Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 468 - 469
Copyright
Copyright © Cambridge University Press 1995

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