The objective of the study was tu evaluate the capacity of rainbow trout to discriminate diets containing micro-granulated or powdered novel fluoroquinolone in comparison with a positive (containing sulfamerazine sodium) and a negative control (placebo). In a first trial, groups of trout had access to a self-feeder containing the placebo feed for 10 days, and then to one of the four feeds during another period of 10 days. Fish reduced their voluntary feed intake (VFI) by more than 50 % when they had access to the positive control, and by more than 20 % when they had access to feed containing micro-granulated premix. There was no significant decrease in VFI when the fish had access to feed containing powdered premix, but in this latter case, an increase in feed refusals was observed. In a second trial, the capacity of the trout to discriminate between two self-feeders containing different feeds was tested. During a first period of 10 days, all the feed hoppers were loaded with the placebo feed, to determine the feeder preference relative to any dietary-independent factor. In the following period of 10 days, fish had access simultaneously to the two medicated fecds. During a third period of 10 days, a validation of the results was attempted, using the placebo feed or the positive control in one of the feeders. It was shown that trout were able to discriminate between the two medicated feeds and that micro-granulated premix was better accepted than powdered premix. In addition, an increase in feed refusals was observed when the preferred feeder was loaded with feed containing powdered premix. It is concluded that this tested fluoroquinolone could decrease significantly VFI. The powdered premix was more detectable by the fish than the micro-granulated premix and led to some refusals.