A description is provided of the anomalous conchiolin deposits which are formed by Pinctada maxima and which are associated with unusual mortalities. Comparisons are made with brown ring disease found in Ruditapes philippinarum and juvenile Crassostrea virginica. In P. maxima, the deposits are not organized into a ring but rather are broad-based and result in retraction of the mantle with the deposits lying outside the edge of the mantle. Vibrio sp. have been implicated in causing the diseases of P. maximaand R. philippinarum whereas the etiological agent of the disease in C. virginica is unknown. It is suggested that the coccoid bodies formed in the mantle of C. virginica, but not in affected P. maxima and R. philippinarum, are sequestered portions of cytoplasm formed as a result autophagocytosis. Stimuli which could be responsible for inducing sequestration are discussed. The ultrastructure of the presumptive autophagosomes is described and compared to similar bodies found in C. gigas infected with a herpes-like virus.