Lexical stress patterns appear to be important in word recognition processes in normal individuals. The present investigation employed a lexical decision task to assess whether left (LHD) and right hemisphere damaged (RHD) patients are similarly sensitive to stress patterns in lexical access. The results confirmed that individuals without brain damage are influenced by stress patterns, as indicated by increased lexical decision latencies to incorrectly stressed word and nonword stimuli. The data for the LHD patients revealed an effect of stress for real word targets only, whereas the reaction time data for the RHD patients as a group showed no significant influence of stress pattern. However, there was a great deal of individual variability in performance. The latency and error rate findings suggest that LHD patients and non-brain-damaged individuals are both sensitive to lexical stress in word recognition, but the LHD patients are more likely to treat incorrectly stressed items as nonwords. The results are discussed in relation to theories of the hemispheric lateralization of prosodic processing and the role of lexical stress in word recognition.