Rb-Sr ages of Swanson Formation on Edward VII Peninsula, West Antarctica, indicate a late Ordovician age, 421–432 Ma for regional metamorphism. K-Ar ages of 113–440 Ma, reflect a second thermal metamorphism during emplacement of widespread Cretaceous granites. Rb-Sr ages of five monzogranite/syenogranitic plutons of Byrd Coast Granite are in the range 95–105 Ma (initial 87Sr/86Sr ratios 0.710–0.715) and represent stages of crystallization of anorogenic granite (A subtype). These correlate with Byrd Coast Granite (100–110 Ma) farther east in Marie Byrd Land, and with Cretaceous granitoids on the Campbell Plateau and in southern New Zealand. K-Ar mica/hornblende and fission-track apatite/zircon ages indicate that regional cooling began c. 90–100 M.y. ago immediately after granite emplacement. Uplift continued throughout the peninsula during the period 55–100 Ma (late Cretaceous-early Tertiary), associated with regional uplift in the rift-drift stages of Gondwana break-up at the South-west Pacific spreading centre. Apatite fission track ages show that during late Cretaceous-early Tertiary time the peninsula behaved as two blocks. The Alexandra Mountains were exhumed 20 m.y. before the Rockefeller Mountains and are possibly separated by a fault active initially in the mid-Cretaceous or earlier, and later reactivated in the late Cretaceous-early Tertiary. An averaged uplift rate (50–100 Ma) of 0.025 mm yr−1 is characteristic of the inferred intraplate tectonic setting.