Depleted mantle model ages derived from granitoids of the Lassiter Coast Intrusive Suite, sampled over a wide geographical area in eastern Ellsworth Land, Antarctica, cluster between 1000 Ma and 1200 Ma and suggest involvement of Proterozoic crust in the petrogenesis of the suite. Ion-microprobe U–Pb zircon analyses from a small intrusion at Mount Harry, situated at the English Coast, yield a concordant age of 105.2 ± 1.1 Ma, consistent with published ages from other parts of the Lassiter Coast Intrusive Suite. Significant variation in the Sr and Nd isotope composition of the granitoids, along the extrapolation of the Eastern Palmer Land Shear Zone (a proposed terrane boundary) located close to the English Coast, is not evident. However, the isotope signature at the English Coast is more homogeneous than the Lassiter Coast; this variation may relate to geographical proximity to the Pacific margin during intrusion, may reflect subtle changes in basement with a broadly similar character across the proposed terrane boundary, or suggest that any major fault structure is located further to the north, with implications for the kinematics of regional mid-Cretaceous transpression.