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Antitumoural activity in Antarctic and sub-Antarctic benthic organisms

Published online by Cambridge University Press:  19 July 2010

Sergi Taboada ,
Luis Francisco García-Fernández ,
Santiago Bueno ,
Jennifer Vázquez ,
Carmen Cuevas  and
Conxita Avila
Sergi Taboada*
Affiliation:
Department of Animal Biology (Invertebrates), Faculty of Biology, University of Barcelona, Avenida Diagonal 645, 08028 Barcelona, Spain
Luis Francisco García-Fernández
Affiliation:
R&D Department, PharmaMar SAU, Pol Ind La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain
Santiago Bueno
Affiliation:
R&D Department, PharmaMar SAU, Pol Ind La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain
Jennifer Vázquez
Affiliation:
Department of Animal Biology (Invertebrates), Faculty of Biology, University of Barcelona, Avenida Diagonal 645, 08028 Barcelona, Spain
Carmen Cuevas
Affiliation:
R&D Department, PharmaMar SAU, Pol Ind La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain
Conxita Avila
Affiliation:
Department of Animal Biology (Invertebrates), Faculty of Biology, University of Barcelona, Avenida Diagonal 645, 08028 Barcelona, Spain
*
[email protected]
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Abstract

A prospecting search for antitumoural activity in polar benthic invertebrates was conducted on Antarctic and sub-Antarctic benthos in three different areas: Bouvet Island (sub-Antarctic), eastern Weddell Sea (Antarctica) and the South Shetland Islands (Antarctica). A total of 770 benthic invertebrate samples (corresponding to at least 290 different species) from 12 different phyla were assayed to establish their pharmacological potential against three human tumour cell lines (colorectal adenocarcinoma, lung carcinoma and breast adenocarcinoma). Bioassays resulted in 15 different species showing anticancer activity corresponding to five different phyla: Tunicata (5), Porifera (4), Cnidaria (3), Echinodermata (2) and Annelida (1). This appears to be the largest pharmacological study ever carried out in Antarctica and it shows very promising antitumoural activities in the Antarctic and sub-Antarctic benthos.

Keywords

Bouvet Islandeastern Weddell Seainvertebratesmarine benthospharmacologySouth Shetland Islands
Type
Biological Sciences
Information
Antarctic Science , Volume 22 , Issue 5 , October 2010 , pp. 494 - 507
Copyright
Copyright © Antarctic Science Ltd 2010

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