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Family-based tests of association and/or linkage

Published online by Cambridge University Press:  09 January 2002

J. C. WHITTAKER  and
A. P. MORRIS
J. C. WHITTAKER
Affiliation:
Department of Applied Statistics, University of Reading RG6 6FN, UK
A. P. MORRIS
Affiliation:
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX4 7BN, UK
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Abstract

The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.

Type
Review Article
Information
Annals of Human Genetics , Volume 65 , Issue 5 , September 2001 , pp. 407 - 419
Copyright
University College London 2001

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