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Evidence of a major gene effect for angiotensinogen among Nigerians

Published online by Cambridge University Press:  01 July 1999

X. GUO ,
C. ROTIMI ,
R. COOPER ,
A. LUKE ,
R. C. ELSTON ,
O. OGUNBIYI  and
R. WARD
X. GUO
Affiliation:
Center for Genetic Epidemiology, Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL
C. ROTIMI
Affiliation:
Center for Genetic Epidemiology, Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL
R. COOPER
Affiliation:
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL
A. LUKE
Affiliation:
Center for Genetic Epidemiology, Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL
R. C. ELSTON
Affiliation:
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH
O. OGUNBIYI
Affiliation:
University College Hospital, University of Ibadan, Ibadan, Nigeria
R. WARD
Affiliation:
Department of Biological Anthropology, Oxford University, Oxford, UK
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Abstract

To dissect the genetic pathway of hypertension, we measured angiotensinogen in 685 members of 186 families recruited from a rural community in southwest Nigeria. Commingling and segregation analyses were carried out. A mixture of two and/or three distributions fits the data significantly better than a single distribution in commingling analysis, suggesting a major gene effect. Segregation analysis confirmed that a recessive major gene model for low values of angiotensinogen provides the best fit to the data and about 13% of the variance was due to the recessive gene segregation.

Type
Research Article
Information
Annals of Human Genetics , Volume 63 , Issue 4 , July 1999 , pp. 293 - 300
Copyright
© University College London 1999

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